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Juxtaglomerular Cell Tumor Case Studies

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Juxtaglomerular cell tumor (JGCT), or reninoma, is a rare renin producing benign neoplasm arising from the juxtaglomerular cell apparatus, generally affecting young adults and adolescents. Clinically, it presents with secondary hypertension and hypokalemia. Since reninoma is curable by surgical resection, it becomes necessary to consider JGCT as a possible differential in patients presenting with secondary hypertension, hypokalemia and excessive renin secretion. Herein we describe a case of a young female presenting with hypertension and a single renal mass.
Case Report
A 24 year old obese Caucasian female presented to the nephrology clinic with longstanding history of hypertension since 18 years of age. Her high blood pressure was associated …show more content…

Apporoximately 100 cases of JGCT have been reported in English literature. It was first described by Robertson et al in 1967 and was given this name by Kihara in 1968 (1, 2). It is seen predominantly in females in second and third decades of life (3-5). Although some cases have been reported in patients who are more than 40 years old (4) as well as in children of less than 10 years age. Most of the symptoms are attributed to hypertension, hypokalemia, hyperaldosteronism and increased renin activity due to secretion by the tumor. These non-specific symptoms are headaches, retinopathy , double vision, dizziness, nausea, vomiting, polyuria and proteinuria (3, 6). Hypertension is mostly present for several years before the diagnosis of reninoma is made. No correlation has been reported of degree or duration of hypertension with tumor size. Three clinical variants have been reported so far: ‘typical variant’ presenting with hypertension, hypokalemia, increased plasma renin secretion and hyperaldosteronism; ‘atypical variant’ presenting with hypertension but without hypokalemia; ‘non-functioning variant’ presenting without hypertension (12). Endoh et al reported a case of non-functioning variant which was discovered incidentally (7). Our patient presented with hypertension, headaches and hypokalemia and increased plasma renin

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