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JIPMER: A Randomized Study

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The institute ethics committee of JIPMER approved this study and written informed consent was obtained from all patients. This was a single center double blind randomized study. Patients between 18 to 60 years undergoing oral and maxillofacial surgery at Dentistry department of JIPMER were randomized in a double blind fashion to receive intravenous paracetamol 1gram over 20 minutes prior to induction followed by normal saline infusion or intravenous dexmedetomidine 1µg/kg over 20 minutes prior to induction followed by 0.5µg/kg/hr. Simple randomization was done by the opaque sealed envelope technique. One of the anaesthetist apart from investigator randomly opened one of the opaque sealed envelope and prepared the drugs accordingly. We excluded

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