Is Alzheimer's Disease Affecting The Brain

Alzheimer's and dementia is one of the many diseases that affects the nervous system, particularly the brain. Acute memory loss is known as dementia. Thus, Alzheimer's is a severe form of dementia. The diagnosis is the brain lacking brain cells and connections due to degradation. Symptoms of Alzheimer's includes memory loss which can range from minor to severe as well as confusion which directly corresponds to memory loss. Groups of nerves work together to focus on specific jobs such as communication and memory. The brain cells work together and “receive supplies, generate energy, construct equipment and get rid of waste.” Alzheimer's is believed to prevent parts of the cell to not function properly. Scientists are not thoroughly sure where the cells malfunction begins. As the cell continues to divide and spread, the infected cells begin to die off leading to damaged brain connections. Scientists believe that plaques and tangles are the cause of the disease. Plaques are “deposits of a protein fragment called beta-amyloid that build up in the spaces between nerve cells.” Tangles are “twisted fibers of another protein called tau that build up inside cells.” Age results in developed plaques and tangles though, Alzheimer patients have an abnormal amount of these

Alzheimer's disease is one of the most common causes of dementia. The term 'dementia' describes a set of symptoms, which can include memory loss, changes in mood and problems with communication and reasoning. These symptoms occur when certain diseases and conditions, including Alzheimer’s disease, damage the brain. Alzheimer's disease could be described as a physical disease affecting the brain. During the course of the disease, protein 'plaques' and 'tangles' develop

Alzheimer 's disease (AD) is a progressive degenerative disease of the brain from which there is no recovery. There are three brain abnormalities that are the hallmarks of the Alzheimer’s disease is initially caused by plaques buildup in the brain’s neurons as illustrated in figure 1. The support structure that allows the flow of the nutrients through the neurons gets damaged and ultimately there is loss of connection among the neurons and they die off (National Institute of Health, 2015). This causes the brain tissue to shrinks, which is called atrophies. All this ultimately lead the victim of this disease to face difficulties in governing emotions, recognize errors and patterns, coordinate movement, and remember. Ultimately, a person with AD loses all memory and mental functioning.

Last year my maternal Aunt Kate passed away. She had been diagnosed with Alzheimer’s disease (AD) about eight years earlier. My maternal grandmother also had been diagnosed with AD before her death. Later this month I will accompany my 77-year-old mother to her neurologist appointment. While she has not been diagnosed with AD, she has been prescribed Donepezil (Aricept), one of the newer drugs that are thought to reduce the decline in memory in patients that have or might be developing dementia. Opportunities to learn more about AD and the effects on the brain are welcome. The Alzheimer’s Association website, ALZ.org, is filled with a wealth of this information. Especially interesting was Inside the Brain: An Interactive Tour. I

It is a disease that we haven’t cured yet but instead have only come up and still coming up with treatment strategies to alleviate its symptoms. AD was first described in 1906 by a German psychiatrist by the name of Alois Alzheimer whilst he was performing a histophathologic study of his patient’s brain, a patient who had been suffering from dementia. His patient’s brain’s autopsy brought to light the presence of two types of lesions, which are senile plaques and neurofibrillary tangles. He saw a visible difference in the brain tissue for it was severely damaged by these lesions. Since then, our knowledge of AD’s cellular and molecular alterations has increased and we have come up with various hypotheses for AD that may soon help in developing effective preventative and therapeutic strategies. One of the most prevailing hypotheses that have already leaded to a number of therapeutic approaches is the amyloid cascade hypothesis. Hence, the following essay will explore the pathology of the amyloid cascade hypothesis and the evidence for and against it. It will also touch upon current progress in clinical trials that test the

Alzheimer’s disease affects the entire brain eventually, but as it moves through the different stages it may affect certain areas more. Before any side effects of the disease become observable, decades of damage to the brain can take place. This is known as the preclinical stage of Alzheimer’s disease. This damage is believed to take place primarily in the hippocampus, where memory functions in the brain. Here is where plaques and neurofibrillary tangles form and cause neuron death, which spreads the damage to other areas of the brain.

Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.

According to data available from the Alzheimer’s foundation every 67 seconds someone develops Alzheimer’s disease and currently at least 5.3 million people are affected by the disease. The numbers are expected to grow as 75 million baby boomers transition into retirement by 2030. Alzheimer disease is a brain disorder that causes decay and dis- function of neurons resulting in memory loss, speech and language impairment. This can also extend to challenges in physical and social behavioural. The brain, consisting of the cerebrum, cerebellum and brain stem is the primary target of Alzheimer’s disease. At three pounds the brain has a network of arteries and a folded cortex that is responsible for memory and movement. These functions are facilitated by a network of neurons. Alzheimer’s disease interferes with these neurons by disrupting electrical transfer; Death of brain cells is inevitable as the cortex shrinks becoming incapable of developing thoughts and memory. The Alzheimer’s patient experiences an altered personality with family members becoming strangers.

According to Lu and Bludau (2011), Alzheimer disease is a degenerative disease of the brain that can lead to dementia and impair all brain functioning. Biologically, Alzheimer’s disease is believed to be caused by abnormal plaques called amyloid plaques, which are a buildup of protein fragments that are thought to be damaging to the brain cells. However, scientists are still unsure if this buildup actually cause the disease or is a result of the disease itself. This disease can also be a result of a genetic mutation, increasing individuals with the gene mutation risk as much as eight times higher than individuals

Alzheimer’s Disease is a disease of the future. With the growing aged population, this disease, which affects primarily the elderly, will become of increasing relevance to the medical profession. Also, the high frequency of Alzheimer’s, and the high cost in labor, money, and material of caring for its victims shall put considerable burden on the society as a whole. Here, however, these issues are not going to be debated. Instead the pathology of Alzheimer’s will be reviewed to the extent it is known today.

Alzheimer 's disease (AD) was discovered by a German doctor Alois Alzheimer in 1906 when he found amyloid plaques and neurofibrillary tangles in the autopsy of a woman who died of an unknown mental disease. The extracellular amyloid plaque deposits, composed of insoluble amyloid-Beta peptide were hypothesized to be the main etiological factor. “The most important abnormality is an excess of Amyloid-beta peptides brought about through either overproduction or failure in degradation.” (Uzun, Kozumplik, & Folnegović-Smalc, 2011) Later, it was discovered that intracellular neurofibrillary tangles composed of hyper-phosphorylated, helically-paired tau

A german Physician Alois Alzheimer did a postmortem (already dead) analysis of one of his patients, her name was Auguste Deter she was admitted to the hospital for the Mentally 111 in Frankfurt in 1901.He hoped to find out the root of the severe and rapid mental deterioration. When auguste was first interviewed she had a fog of confusion and also showed delusion behavior. She would have a lot of jealousy for her husband; she would start screaming thinking everybody wanted to kill her; she became wild and couldn't be controlled. She then died five years after she was put in the Hospital .When Alzheimer took a thin slice of her brain and put it under the microscope he found the following: that next to the nerve cells was a small clump that

Alzheimer’s disease is a common problem in today’s society and within the older population this disease makes up the largest form of dementia. Although it is a problem in mainly older people, this disease can still occur in the younger population also. People in their 30s-50s can be diagnosed with this disease, even though it is not as common as people in their 60s-90s. The number of people with Alzheimer’s in the U.S. is close to five million and is expected to double within the next 30 years. With our modern medicine and advancements one would think a cure would be available, however, getting to the cause of the disease is a major factor. The cause of Alzheimer’s disease is one that is very debatable and questionable and most likely is a result of multiple factors rather than one. The main issue with finding the cause is because this disease affects the brain and can

Alzheimer’s disease (AD) is a neurodegenerative disorder involving senile plaques distributed throughout the cerebral cortex and intracellular neurofibrillary tangles. These plaques are predominantly composed of beta-amyloid (Aβ), which is a 39 to 42 amino acid peptide and is cleaved from the (APP). With 1 in every 14 people over the age of

According to the Alzheimer’s Foundation of America, Alzheimer’s disease is a disorder that results in memory loss, failed cognitive and language skills, and behavioral changes from progressive and degenerative damage on the brain’s neurons (Alzheimer’s Association of America, n.d.). The disease was first identified in the early nineteen hundreds by a German physician, Alois Alzheimer (Alzheimer’s Association, n.d.). Dr. Alzheimer’s began his research on the condition after a patient whom suffered from severe memory loss and psychological changes (Alzheimer’s Association, n.d.). The autopsy performed after the patient’s death led to the discovery of the disease (Alzheimer’s Association, n.d.). The causes, symptoms, and treatment methods for Alzheimer’s disease will be discussed in this paper.