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Investigation Of Vitro And The Vivo Antifungal Activity Of Different Plant Acetonic Extracts Against Fungal Skin

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Investigation of in vitro and in vivo antifungal activity of different plant acetonic extracts against fungal skin isolates
ABSTRACT
T he worldwide increase of multidrug resistance has impaired the current antimicrobial therapy, warranting the search for other alternatives.This study investigated the efficacy of using plant extracts; Lawsonia inermis L(Henna), Glycyrrhiza glabra L(licorice) and Rosmarinus officinalis L (Rosemary) as antifungal agents.Antifungal susceptibility test revealed that nystatin were mostly active against tested clinical isolates. In vitro antifungal activity of the different plant extracts against isolates showed that acetonic extract of licorice, had high antifungal activity. In vivo study, topical application of licorice gave promising and excellent healing response. We propose that the higher percentage of (GC-MS) of 3-O-Methyl-d-glucose 29.1 %, most probably are the causes of its higher antifungal activity.
INTRODUCTION
Fungal and bacterial skin infections are of public health concern as they can elicit social, economic and public health problem (Maseleno and Hasan, 2013). Heavily infected persons with visible lesions are often unconscious targets of social stigma of rejection isolation because of their unslightly appearance. The cost of long term diagnosis and treatment can be over bearing for low income individuals who make up the bulk of developing countries where these infections occur in epidemic proportions due to poor hygiene. It

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