Insulin

regulate glucose levels had artificially been altered (“The Discovery of Insulin”). The results were groundbreaking and the diabetic dogs responded well to the injections, marking a major step forward in diabetes research (“The Discovery of Insulin”). Through the help of Professor John Macleod of the University of Toronto, they were able to continue their research (“The Discovery of Insulin”). Finally, in January of 1922, testing Dr. Banting’s developments in diabetes treatment on human beings had finally been completed and the results led to the ultimate development of the insulin treatment that is still used to this day (Simoni, Hill and Vaughan 31).

The Diabetes Quebec Association states that in the past, "a diagnosis of diabetes meant certain death". This was held true until a Canadian physician, Frederick Banting, discovered the hormone insulin in 1921. He was able to isolate a unknown matter from the pancreas of a dog and inject it into another dogs pancreas 's. This discovery enabled them to save the lives of these diabetic dogs. Through trial and error Banting was able to perfect the purification of insulin in order for it to be injected on a daily basis to compensate for the insulin not being produced by the pancreas to control the blood sugar in hyperglycemic patients.

The development of insulin saved many lives throughout the 1920’s. Insulin allows your body to turn blood sugar into energy, and diabetes patients don’t have an important hormone called insulin. In fact, thousands of people had this issue. In the 1900’s, the only treatments for diabetes were starvation diets and very strict exercise program. Dr. Frederick Bating, the inventor of insulin, had spent a lot of his time studying the disease of diabetes. He thought if he could isolate insulin in animals, it would be possible to use it to treat people with diabetes. Later on his theory proved to be correct. Dr. Frederick Banting needed a lab to test his theory and work on it so he could have insulin mass produced and treat the disease of diabetes.

Eventually by the beginning of December, they were finally ready to try this regimen on people. Then, John Macleod decided that isletin was not easy to say because it did not roll off of the tongue that well. Thus, so the name changed from isletin to insulin. In the beginning of January of 1922, a young boy with diabetes was the first human treated with insulin. The boy was in the hospital and continued to receive treatments. When the treatments were almost finished, he was more active, stronger, and looked better. Insulin was successful on humans too (The History). Therefore, it became extensively available. In order to have

Though there are many hypoglycemic agents available for the treatment of diabetes, insulin remains an important therapy for patients with type 2 diabetes. This is because the natural history of type2 diabetes is characterized by progressive loss of beta cell function resulting into type 1 phenotype [28]. Due to this, exogenous insulin therapy is often required to achieve optimal glycemic control, even in type 2 diabetes [29]. If insulin is used appropriately, it is almost always

Insulin resistance is the first physiological change occurring in type two diabetes. In these type two diabetic patients, insulin is unable to move glucose into liver, kidney and muscle cells although insulin is able to attach properly to the cell surface receptors. In order to rectify this, most patients with type two diabetes start secreting normal to very high levels of insulin, which can initially overcome this resistance. After a while, the pancreas cannot keep up with this high insulin production and the cells become resistant to glucose intake. Persistent hyperglycemia or high blood glucose levels are not desirable since this causes damage to the beta cells of the pancreas that produces the insulin hormone. This damage to beta cells further hampers insulin synthesis and patients at this stage are categorized as full-blown diabetic. Such patients consistently show a hyperglycemia state even after hours of fasting ( Hinkle & Cheever,

Before Charles Best and Frederick Banting discovered insulin, the main treatment for diabetes was an extremely low-calorie diet, it would be low as 450 calories a day. Since there was no treatment for diabetes, getting it would be a death sentence and unimaginable to treat. Now thanks to Banting and Best, millions of people back then and millions of people now live with it every day. This is all possible because of Frederick Banting and Charles Best ’s hard work and dedication it helped many people co-op with diabetes with insulin. Charles Best left a huge mark and long-lasting impact that have helped many people all around the

In conjunction with the advancement in recombinant DNA technology, various insulin analogues have been produced which exhibit similar pharmacodynamics effects but modified pharmacokinetic properties. Insulin lispro, insulin aspart and insulin glulisine are the examples of rapid-acting insulin analogs which are commercially available in the clinical settings. Due to the reason of rapid onset and early peak action which closely mimic normal endogenous prandial insulin secretion as compared to regular insulin, rapid-acting insulins allow more physiologic prandial insulin replacement. On top of that, rapid-acting insulins permit to be taken immediately before the meal without sacrificing glucose

Beta cells in the islets of Langerhans secrete insulin, a small protein (or hormone) made of two chains

Insulin was discovered by Banton and Best in 1922 (Nobelprize, 2009). Even though insulin cannot cure the diabetes, still one of the major discoveries in science. Lot of people with diabetes type 1 were saved from death. Moreover, with the regular use of their insulin, they could live a practically ordinary life. Insulin used to be gained only from non-human sources, example pigs and cows. Due to its origin, it was not entirely pure therefore the long term use may can cause damage in the body as it form immunological reactions by the immune system. The immune-system detects and identifies this non-human insulin as foreign particle and destroy it with antibodies. Nowadays, the advanced DNA technology has made available the human insulin for

An organ called the pancreas makes insulin. The role of insulin is to move glucose from the bloodstream into muscle, fat, and liver cells, where it can be used as fuel.

It is not news to anyone that one of the most known disease in the world is diabetes mellitus, people with type two diabetes produces some insulin, but not enough to keep their blood sugar at a normal level, however the one that are affected by the type 1 diabetes or childhood-onset type 1 DM do not produce insulin at all. Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. (ADA, 2015) . That circumstance puts them at greater risk for heart disease, renal disease and blindness to name a few. Sadly Worldwide, the occurrence of type 1 DM has been steadily rising, representing a significant burden on the people and to the health-care systems. Although momentous improvements in the care of T1DM patients, a subsection remain in major difficulty due to stubborn hypoglycemia. The possibility of IT offers the chance of better glycemic mechanism. Currently we are observing considerable advancement in the number and results of IT phenomenal. In type 1 DM is an autoimmune disease that causes the body the destruct the b cells in the pancreas, which are responsible for the production of insulin. As a result, supplementation of insulin is a must in the management of the disease through meticulous care of multiple daily injections to control blood glucose. Even accommodating to the treatment many do not maintain a stable blood glucose level and are at risk for metabolic problems. Ultimately replacing of β cells are the only

As mentioned, insulin is a premier hormone in the regulation of blood glucose levels; however, resistance to insulin stimulation is a common phenomenon and plays a critical role in the pathogenesis of several human diseases. Himsworth first demonstrated the fact that a sufficient amount of the patients with diabetes are “insulin insensitive” about 50 years ago; on the basis of this finding, he suggested that patients with diabetes are either insulin sensitive or insulin insensitive (Himsworth, 1936).

All types of diabetes are related to a deficiency in the hormone insulin, which is secreted by the beta cells os the pancreas. In a healthy person, insulin is produced in response to elevated levels of glucose in the bloodstream and its major role is to control glucose concentration in the blood by letting the glucose enter our cells and lowering its levels. What insulin does is allowing the body cells and tissues to use glucose as a main energy source, it is also responsible for conversion of glucose to glycogen for storage in the muscles and liver cells. The pancreas plays an essential role in converting the food we eat into

Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.