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Influenza Vaccine Essay

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Influenza vaccine research has one ultimate goal: finding the effective vaccine which generated stable antibody recognizing the influenza virus. Influenza viruses have notoriously known for rapid genome mutation, thereby vaccine formulated this year will not work properly for preventing the coming-years flu, making the flu vaccine needs to be administered on the regular basis. This is exacerbated by the fact that influenza virus has eight segmented genome which can be shuffled among different strains, creating a new combination. Novel strain-viruses are crafted during that processes or termed as genetic shift and unfortunately, our immune cells don’t have collection of antibodies for tackling the virus. The viruses are able to spread pervasively and inevitably, viral epidemic followed, such as swine flu or H1N1 viral outbreak occurred several years ago.

Recent research explores the nature and presence of boardly-neutralizing antibody (bnAb) which targets a great number of influenza virus strain. As a sort of universal-influenza vaccine, this …show more content…

Instead of targeting the head parts of heamaglutinin, the neck part beneath of the head used for this purpose. Genomic comparison shown that this region underwent relative little genetic mutation, thus making a perfect choice for vaccine candidate. Although similar in different influenza viruses’ strain, creating vaccine from this region isn’t easy as it predicted. Removing the head parts (which has large variability) tends to make the protein unstable and owing to its small size it is apparently that the particle don’t elicit strong immune protection. Research comes up for overcoming this downside by attaching the stem parts into ferritin nanoparticles. Single molecule of nanoparticles holds several vaccine-proteins and yet the protein still retain its functional capabilities, resulted in an effective protection towards different strain of influenza

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