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Hypertension Essay

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Hypertension is one of the major risk factors for the development of cardiovascular diseases including stroke and may also have a role in the development of vascular cognitive impairment and vascular dementia [1, 2]. Angiotensin I-converting enzyme (EC 3.4.15.1; ACE) plays an important role in the rennin-angiotensin system and it is a carboxyl-terminal dipeptidyl exopeptidase that catalyzes the conversion of angiotensin I to angiotensin II [3-6]. ACE converts an inactive form of decapeptide, angiotensin I, to a potent vasoconstrictor, octapeptide, angiotensin II, in addition; since the ACE is a multifunctional enzyme it also catalyzes the degradation of bradykinin, which is known as a vasodilator [4, 7]. Therefore, inhibition of ACE …show more content…

Secondary or primary metabolites produced by these organisms may be potential bioactive compounds of interest in the food and neutraceutical industries. The worldwide demand is growing for seaweeds as useful resource for food ingredients and processed foods [22, 23]. Therefore, algae can be a very interesting natural source of new compounds with biological activities that could be used as functional ingredients. E. cava, a kind of brown alga (Laminariaceae) that is found abundantly in the sub tidal regions of Jeju Island, Korea and Japan [24]. It is plentifully produced Jeju Island of Korea for commercial purposes. This brown seaweed is popular in Korea and Japan as a food ingredient, supplement of animal feed and fertilizers [25]. In addition, increasing number of scientific papers published for last few years highlighting that various biological activities and their possible industrial applications of the brown seaweed E. cava.
Polyphenol has been emerging as one major category of natural products that is important to human health. Increasing scientific evidence shows that polyphenols are good antioxidants, are effective in preventing cardiovascular and inflammatory diseases, and can also be used as chemo-preventing agents for cancer [26]. Phlorotannins (brown-algal polyphenols) are the least studied group of tannins and are found only in brown algae. Phlorotannins, a subgroup of tannins, are produced entirely by polymerization of

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