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Hydrogel dressing in comparison with hydrocolloid

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Hydrogel dressing in comparison with hydrocolloidIntroductionWound repair may be divided into three overlapping phases, namely the inflammation granulation, and the matrix formation and re-modelling phases. In the inflammation phase, macrophages participate in the cleansing of the wound and are also responsible for initiating angiogenesis and the appearance of fibroblasts through the action of the cytokines they release. (Panchgnula and Thomas 2000 131-50) In the second phase of wound healing, granulation tissue appears, and consists mainly of fibroblasts which actively synthesize collagen precursors. These are deposited in the extracellular matrix, and crossed-linked to give tensile strength to the newly healed wound. The remodelling …show more content…

For example, diverse structures can be gained upon dehydration of the hydrocolloid making. These structures can be customized by the ventilation conditions and formulation making. (Katzung 2004 160-240)Structural characteristics for example porosity might influence the diffusion rate of liquid into the making and thus adjust the release prototype of the drug. Additionally, hydrocolloid-formulation grounding procedures are usually fairly easy and the cost of such materials is small. Diltiazem hydrochloride is a calcium antagonist used to moderate systemic hypertension. Antiarrhythmic effects of the drug control the ventricular response to atrial fibrillation and flutter. This mix is also used for the handling of steady and unbalanced angina pectoris. Although most of the administered drug dose is absorbed (90%), its bioavailability only reaches 3065% because of a high first-pass effect, mainly in the liver and the gastrointestinal tract. (Zohar et al 2004 249-58)Diltiazem hydrochloride has a short plasma half life of 34 h1 and should be taken three to four times a day. Consequently, controlled/sustained-release mixtures for diltiazem hydrochloride are desirable. The objectives of this study were to formulate and characterize dried carriers based on alginate, agarose, and gellan that contain fillers (talc, kaolin, calcium carbonate, potato starch, and corn starch) and diltiazem hydrochloride. (Panchgnula and Thomas 2000 131-50) These fillers are sold as powders and

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