How Sickle Cell Disease Affects People

Sickle Cell Anemia is a genetic disease which can only be caused by both parents passing the sickle cell gene down to their offspring. About 2 million Americans carry the Sickle Cell gene but don’t have the disease. If two people with the gene marry, there’s a one in four chance that their children can end up having the disease. The gene is common with African, Spanish, Mediterranean, Middle Eastern, and Indian people. In the United States, Sickle Cell Anemia affects 1 in every 500 African American children born, and 1 in every 900 Hispanic children born.

Sickle cell disease (SCD) occurs in 1 out of every 365 African American births compared to 1 out of 16,000 Hispanic-American births (1). SCD is a group of red blood cell disorders in which patients have a sickle or moon-shaped red blood cell due to an abnormal S hemoglobin. While sickle cell disease is relatively rare in American births, this is an alarming statistic among people of Sub-Saharan (west and central) African descent. An interesting fact is that SCD occurs more often among people from parts of the world where malaria is or was common, such as Sub-Saharan Africa (1). In addition, it is believed that people who carry the sickle cell trait are less likely to have

Now that the disease is more clearly defined, we must ask, why did this illness come about? This is one of the most interesting facts about Sickle Cell. Since the trait originated in countries that were ravaged by malaria, it could be said that this trait evolved to fight the deadly mosquito-spread disease. "People with sickle trait were more likely to survive malaria outbreaks in Africa than those with normal hemoglobin, it is

Sickle cell anemia is an anemia that is inherited and mostly affects people whose heritage can be traced back to places where malaria was prevalent. There are approximately 100,000 Americans that have the disease and many more with the trait. Several of my family members are afflicted by this medical condition that causes red blood cells to take on an irregular shape.

Both parents must pass the sickle cell disease on for major type but if one parent passes it and the other doesn't, the offspring will have a lesser version with both healthy and unhealthy cells called sickle cell trait (NIH, 2015). Although this sounds detrimental, this more “minor” disorder is asymptomatic and can be the salvation for certain people (Rosenthal, 2011). Even though this disease is genetic, there was a person who discovered that it was originally environmental. So how would have this sort of condition come

Sickle cell anemia is a blood disorder that happen very commonly in the African descent.

Sickle cell anemia affects a wide range of demographics, from young to old. However, there are specific groups of people who are likely more prone to this disease than any other group. This disease affects millions of people worldwide regardless of age, but it is particularly common amongst those who derive from specific regions of the world. Sickle cell anemia is most common in those whose ancestors are derived from the sub-Saharan region of Africa. Furthermore, other regions that are known to have a high number of people containing sickle cell anemia are from Mediterranean countries, the Arabian Peninsula, and Spanish-speaking regions as well ("Who Is at Risk for Sickle Cell Anemia?"). This disease originated from the sub-Saharan region of Africa, and later migrated to other areas through the spreading of other diseases such as malaria. This is due to the fact that sickle cell disease occurs habitually in areas that are prone to diseases such as malaria. Although this disease can affect anyone, the highest cases of sickle cell anemia were found in African-Americans than in any other race. In the United States, sickle cell disease affects about 70,000 to 100,000 Americans ("Who Is at Risk for Sickle Cell Anemia?"). The statistics show that 1 out of every 500 births is affected by sickle cell disease for African-Americans. For the Hispanics, 1 out of every 36,000 births is prone to sickle cell disease ("Who Is at Risk for Sickle Cell Anemia?"). The age ranges for which a

The disease I choose to talk about is Sickle Cell anemia, which is a blood disease that is prevalent among the African American race. This disease is interesting to me because it is a hereditary disease, so it can only be contracted if your parents have the disease. Sickle Cell anemia is caused by abnormal hemoglobin, the red blood cells in your body contain two vital hemoglobin molecules, a protein that carries the oxygen through your blood to travel throughout the body. People with sickle cell anemia, they have two copies of abnormal hemoglobin referred to as hemoglobin S. The molecule is what causes the problems within the red blood cells, rendering them unable to properly complete the process of carrying oxygen where it needs to go.

In 1972, Dr. James V. Neel, chairman and founder of the Department of Human Genetics at the University of Michigan, created the first center of sickle cell disease (Winter). Sickle Cell Disease(SCD) is an inherited red blood cell disorder that causes the cells to be sickle in shape due to the mutation of the hemoglobin gene (Winter). People with SCD

Sickle cell disease is a disease that is most prevalent in people of African descent along with people of Mediterranean and Middle Eastern origin. This disease is known to affect about 70, 000 Americans and about 2 million people carry the trait (meaning that, they carry a single gene mutation).

Even the slightest changes within a single protein may greatly affect the health of a human being and their descendants. Sickle cell blood anemia is a type of blood disorder in which the proteins within the affected person have slightly mutated in order to form a sickle shaped cell. This can cause chronic health problems to a patient that has sickle cell anemia since their sickle shaped blood cells may obstruct their circulatory system. Despite this disease being chronic, a patient can only get sickle cell anemia if they have inherited it. Sickle cell anemia is most commonly inherited by African Americans and Hispanics. In other words, sickle cell anemia is a chronic disease in which a person is inheritably born with some sickle shaped blood

The purpose of this essay it to determine whether or not Jonathon Jackson, a 30 year old air traffic controller whom has been faithful to his company and job for over eight years that has recently discovered he has sickle cell anemia, should be dismissed from his job regarding his genetic test results. Sickle cell anaemia is the most severe form of sickle cell disease and is a genetic disease of the red blood cells (Gibbons, 2015). Red blood cells have a disk like form which allows them the ability to travel through blood vessels. Although in people with sickle cell, the red blood cells form an abnormal crescent shape which makes them rigid and sticky as shown in Diagram 3 below. This causes the sickled cells to get trapped in small vessels which blocks blood from reaching different parts of the body leading to pain, tissue damage and many more symptoms (University of Utah, 2015). The term anaemia comes from having a shortage of red blood cells in your blood which occurs because sickled cells only last up to 10- 20 days while normal red blood cells last approximately 120 days. The name ‘sickle’ comes from an old farm tool known as a sickle as shown in Diagram 4 below which represents the same shape as curved sickled cells (Petch, 2012). Sickle cell disease affects millions of people worldwide and is most common in those who have ancestors from Africa, the Mediterranean, The Arabian Peninsula and Spanish speaking areas in South America. People with sickle cell anaemia on

For long time many people have traditions habits that help to spread sickle cell anemia in community. It is common in the east of Saudi Arabia. Because in my community some people get married of relatives, that makes disease in their children if parents have the disease. Sickle cell anemia is genetic disease, which is characterized by abnormally in the hemoglobin molecule that carries oxygen in red blood cells. It is associated with sickle cell disease with a number of acute and chronic health problems, such as acute infections, attacks of severe pain, and stroke. There is an increased risk of death. The effects of sickle cell anemia are high body temperature, bacterial infections, and lack of oxygen in the blood.

Sickle cell anemia is an autosomal recessive point mutation that is often attributed to populations in Africa and the Middle East. This is due to a the high occurrence of malaria in these regions, however, the rate at which both sickle cell anemia and malaria are occurring in other regions of the globe is becoming increasingly prevalent. Immigration during the past few decades has resulted in what is now being considered an epidemic. The resources available to treat those with these diseases in more developed nations are abundant in comparison to places in Africa and the Middle East, yet regardless of treatment options, those who have sickle cell anemia still suffer greatly. How a society manages this illness is based on resources, treatment options, and funding. In some areas, sickle cell is more widespread than in others and the impact on the society yields a greater threat. In order to better understand the disease, one must start at the foundations and work upwards, following its progression and migration throughout the world.

In the annals of medicinal history, 1910 is viewed as the date of sickle cell disease. The disorder, Sickle Cell Disease, had been existent in Africa for at least five thousand years and had been known by numerous names in numerous tribal languages. It is called discovery in 1910 in the United States but not in Africa. A young man named Walter Clement Noel from the island of Grenada went to Dr. James B. Herrick and explained what he felt of pain and symptoms of anemia, but the Dr. Herrick is a cardiologist, which is a specialist in heart, so he took him to Dr. Ernest Irons. Dr. Ernest Irons examined Noel's blood under the microscope and saw the changed in shape of red blood cell. When Herrick saw this in the diagram, he became interested because he saw that this may be a new disease. Thus, Dr. Herrick advertised what he found in Noel's blood in one of the medical journals. After that, many articles about sickle cell disease appeared. For example, two articles had appeared in 1949, and this disease became known more than before.