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How Does Air Pollution Induce COPD Exacerbation?

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Epidemiologic studies have indicated that air pollution can induce COPD exacerbations. The increased concentration of dioxide (SO2) and nitrogen dioxide (NO2) in particulate matter up to 10 μm in aerodynamic diameter, and black smoke particulate matter can increase respiratory mortality in patients with COPD [113, 114]. Some clinical studies showed that air pollution may account for approximately 6 to 9% of admissions, depending on the time of year [114]. Patients with COPD have also been shown to be at increased risk of death associated with urban particle air pollution [115]. Studies in vitro have shown that diesel exhaust particles stimulated production of pro-inflammatory cytokines such as GM-CSF and IL-8. These cytokines may be involved

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