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Gliotocus Fumigatus Research Paper

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Toxin
Gliotoxin
One of the most well-studied secondary metabolites produced by A. fumigatus is gliotoxin, Gliotoxin (C13H14N2O4S2) is a member of the epipolythiodioxopiperazine (ETP) class of toxins, characterized by the presence of disulfide bridge across a dioxopiperazine ring (Gardiner 2005). Biosynthesis of Gliotoxin occurs due to the condensation reaction of serine and phenylalanine amino acid which is catalysed by a nonribosomal peptide synthetase (NRPS) [ Gardiner 2005] The studies have shown that 96% of virulence caused by Aspergillus fumigatus is due to the presence of gliotoxin which facilitates fungal growth and colonization of host tissue through initiation of a local or generalized immunosuppression mechanism. The various role

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