GERD study register patient will be based on the Clinical practice guideline recommendation8. The purpose of the investigation is to identify the subject who meet the following indication and any contraindication. Indications: Age > 18 years and < 80 years symptomatic GERD patient for at least 6 months who having partially or complete response to medical treatment Contraindications: Patients who condition are not candidate for surgery The study is Prospective cohort study that all the consecutive subjects meet inclusion criteria. The study is designed to collect both safety and effectiveness information. Study objective The primary endpoint is a successful outcome in term of reducing symptom, as measured by GERD-HRQL ( Gastroesophageal
For the purpose of this study, a retrospective cohort design will be implemented in the form of longitudinal study. Retrospective cohort studies are a type of observational study. It utilises a retrospective cohort methodological approach. Retrospective cohort studies use data that have already been collected for studies with similar
Commonly known as heartburn or reflux, is a condition where reflux of the gastric content into the oesophagus leads to symptoms which significantly impact a person's quality of life. Gastroesophageal reflux disease gerd is the most prevalent acid related disorder and is associated with significant impairment of health-related quality of life. Gastroesophageal reflux disease gerd occurs when acid and food in the stomach back up into the esophagus.Gerd often occurs when the lower muscle (sphincter) of the esophagus does not close properly. The sphincter normally opens to let food into the stomach. It then closes to keep food and stomach acid in the stomach. If the sphincter does not close properly, stomach acid and food back up (reflux) into the esophagus. The following may increase your risk for gerd. Gerd may be associated with several extra esophageal syndromes such as chronic cough, asthma, laryngitis, oropharyngeal ulceration and dental erosions. Available evidence indicates that therapy response rates in gerd are related to the degree of acid suppression achieved. Having an appropriate discussion with a physician is key to understanding the condition, available treatment options and the degree to which acid suppression can be achieved.
When suffering from GERD, it is important to know how to adjust in order to decrease the likelihood from suffering from signs and symptoms of this disease. A person with GERD should try to figure out what kind of food triggers the reflux. There are many foods that may irritate our stomach, for example, coffee, alcohols, tomatoes, and fatty foods, however, each and every one of us may be sensitive for a particular food/beverage and once we find out what it is we have to eliminate it. It is also crucial to decrease the size of our meal. If we are prone to acid reflux, it is important that we don’t lie flat for three hours after we have eaten a meal or snack.
The target population would be men/women aged 18-60; and to be enrolled on the initial 3month block the patient will have to meet the following criteria;
Gastroesophageal reflux disease is characterized by a variety of symptoms, including the common “heartburn” and acid regurgitation, as well as the not so common chest pain (unrelated to the heart), chronic cough, hoarseness, and throat irritation. It is more familiarly known as GERD and is one of the most common chronic and rapidly growing diseases of today; yet, the underlying cause is still unclear. There seem to be many different theories on what causes GERD, but the most common treatment is the Proton Pump Inhibitor (PPI).
While antacids are used largely by the general public, there are no studies showing that they help or are effective in treating GERD. They are simply mechanisms to treat symptoms of a larger problem. PPI are the most effective for the treatment of GERD. The medication is orally administered as an inactive counter-part. It is converted to the active form by parietal cells in the stomach. Once active the drug causes irreversible deactivation of the enzyme that generates gastric acid. Because the deactivation is irreversible, the decrease is acid is effective until more enzyme can be produced. The goal for PPIs is to reduce stomack acid and to prevent stomach ulcer and further exacerbation of esophagitis. The medication may cause headache, diarrhea, nausea, and vomiting thought the incidence of occurrence is very low. PPIs do increase the likely hood of the development of pneumonia due to the altered GI flora. Another major adverse effect is the rebound hypersecretion of acid. Patients who discontinue taking PPIs may experience dyspepsia due to acid rebound. This can be minimized by using the lowest dose and tapering the medication. Histamine receptor antagonists, though indicated for the treatment of GERD are not as effective at decrease stomach acid. PPI can decrease acid content by 90% whereas H2RAs only decrease by 65%. The medication works by blocking H2 receptors on parietal cells in the
Functional studies showed decreased LES function with a low amplitude of acid clearance and primary esophageal peristalsis in cirrhotics with large varices [9]. These phenomena could also be due to a mechanical effect of the varices. Cirrhotic patients without EV have also esophageal motor disorders and mixed acid and bile reflux as the main pattern whereas the cirrhosis itself was an important causative factor. It is unclear whether this might contribute to bleeding from varices [8]. Data on management of GERD in cirrhosis are few, however, the indications of use for PPIs may remain exactly the same also in patient with cirrhosis of the liver as general population for the treatment of erosive esophagitis or in general the pathology secondary to gastroesophageal reflux acid (10)
Gastroesophageal Reflux Disease (GERD) is a disease of the digestive tract that can cause asthma and other complications. GERD does not affect the heart itself even though the heart can burn as a result; GERD can mimic the signs of a heart attack. This report will discuss how a prescription is not necessarily needed for treatment, medicine can be purchased OTC. This disease also affects infants and small children.
Gastroesophageal reflux disease (GERD) is a symptomatic condition or a histopathologic alteration thought to be secondary to a reflux of gastric contents that enter the lower esophagus. There are treatment options to help patients with the symptoms of GERD. Although the treatments prove to help relieve the symptoms of GERD, some question their overall effect on the body and whether or not they are safe to take. Recent studies are suggesting herbal formulas may have the best treatment outcome.
This condition may be diagnosed during testing for GERD. Tests that may be done include:
GERD is relaxation or incompetence of the lower esophagus persisting beyond the newborn period. Relaxation of the
The doctor diagnose GERD based on: The symptoms, which the patient has like common heartburn and other symptoms, the doctor also will make a test, which will determine the amount of acid inside the food pipe. The device determines when and for how long stomach acid backs up into the food pipe. There are two kind of devices. One is a catheter, which will be inserting in the nose into the food pipe. The other one is a clip, which is positioned in the food pipe during endoscopy. If the patient has GERD and has to have a surgery, he or she also may have other tests like: an x-ray of the upper digestive system. The patient drinks a chalky liquid, which coats the inside covering of the food pipe, this allows the doctor to see a silhouette of the
IV trying to avoid lying down after a meal, eat smaller food, because of heartburn is
The method adopted was quantitative in nature, using a randomized controlled trial. In order to achieve this, 71 adult patients were assessed for eligibility and among this 59 met the given criteria. They were randomly categorized into treatment groups consisting of 29 patients and a control group consisting of 27 patients. The randomization was done by the same nurse who recruited the patients for
However, there is no clear evidence that screening leads to a reduction in mortality. The American College of Gastroenterology (ACG) supports the use of endoscopy as a screening tool but only if there are GERD symptoms in the presence of alarming symptoms (dysphagia, weight loss, and signs of gastrointestinal bleeding). An international consensus statement recommended to endoscopically screen men after the age of 60 years who have chronic