Fluvastatin Lab Report

statins reduce the blood cholesterol level and decrease atherosclerosis build up in the coronary arteries.

High cholesterol level is a condition in which the concentration of high density lipids (HDL) specifically cholesterol, has significantly increased in the blood. The build up of these lipids in arteries reduce the supply of blood and hence, oxygen to the heart. Consequently, high cholesterol can lead to stroke or heart attack. Apo – Atorvastatin (Atorvastatin Calcium Tablets) is a medication that helps lower the concentration of cholesterol and other HDL in the blood (Apo-Atorvastatin, 2011) and is manufactured by Apotex Inc.

She has been off simvastatin because of the myalgias. Her lipids were most recently checked back in June and were elevated. Total cholesterol 270, triglycerides 199, HDL 59, LDL 171. She really wanted to work on healthier lifestyle choices, which she is trying to do, but is still struggling with. She has not been using her exercise bike of late, as her basement was being renovated, though she plans to start doing that soon. She would like to continue to work on those things, but does admit that she has difficulty. She would be willing to consider an alternative statin than simvastatin because of her prior issues, but would perhaps like to recheck them

In this experiment, the reduction of a ketone to an alcohol using sodium borohydride was demonstrated. When the solution turned from yellow to colorless, sulfuric acid was added and the solution was set under reflux to allow for the complete dissolution of the solids. After cooling, the product was then isolated using vacuum filtration before mixed solvent recrystallization was used on it. An infrared (IR) spectra was obtained for the product along with the melting point and weight. The weight was further used to calculate the percent yield.

J.J. explained her atorvastatin calcium medication is used for treating her high cholesterol. Atorvastatin calcium is an HMG-CoA reductase inhibitor, therefore meaning it lower lipids (fats) in the body (MedlinePlus, 2018). Atorvastatin calcium works by lowering high cholesterol levels (MedlinePlus, 2018). Atorvastatin calcium

The patient was put on a low fat and low cholesterol diet to see if the symptoms would improve and the cholesterol levels would decrease along with some statin medication of Atorvastatin, to help lower the cholesterol within the blood and help to prevent the patient from gaining any associated symptoms that are related with cardiovascular disease. The medication was given as it inhibits HMG-CoA reductase of the enzyme found within the liver that has a huge role in the production of cholesterol. This should show a dramatic reduction in the levels of LDL-C.

Cardiac Disease /Circulatory-Medium risk: Cholesterol, triglycerides and HDL levels will improve through the use of medication and diet within the next 12 months (current levels 204, 244, 33 respectively)

Lovastatin, a natural product drug, is a cholesterol-lowering agent isolated from a strain of Aspergillus terreus. It is an oral antilipemic agent produced by fermentation of fungus. This drug is highly lipophilic and belongs to the class of medications called statins.1 Statins, also known as HMG-CoA reductase inhibitors, are a class of drugs that lower the level of cholesterol in the blood by reducing the production of cholesterol by the liver. Statins block the enzyme hydroxy-3-methyl-glutaryl coenzyme A reductase(HMG-CoA) in the liver that is responsible for making cholesterol. Lovastatin is a prodrug which lowers the cholesterol level through reversible competitive inhibition of HMG-CoA.2 By lowering high cholesterol in people with hypercholesterolemia,

Clinical trials have shown that statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reducatse can reduce cardiovascular evenrts (^1). Statins reduce the rate of cardiovascular events by lowering LDL levels “bad cholesterol”. Guidelines used for prevention of cardiovascular disease have

The intriguing discovery of warfarin begins in the 1930’s in the cattle pastures of North America and Canada. During this time, many farmers began to realize that much of their healthy cattle was unexpectedly getting very sick and subsequently dying due to internal bleeding. The farmers could not find any pathogenic organisms or dietary insufficiency responsible for these deaths. This problem was rapidly distressing the farmers’ livelihoods and the economy. At this time American economy was already suffering due to the great depression only a few years earlier and livestock was one of the most important industries in the area. The 2008 Authors Journal Compilation talks about the diet of the cattle during this time. The cattle and sheep had

Patient has a CVD (cardiovascular disease); can be exacerbated by having high cholesterol (could be the cause of his angina). Therefore, atorvastatin 80 mg was initiated for secondary prevention of CV

Early initiation of lipid-lowering therapy and lifestyle measures might modify the clinical outcome. These treatment initiatives have especially improved the prediction of HeFH. All of the medications used for heterozygous FH are also used to treat homozygous FH, such as bile acid absorbing resins, drugs “Shatins” are used. People with homozygous FH often undergo LDL apheresis, a process by which blood is removed through the patient’s vein and LDL is filtered out before the blood is passed back into a different vein, similar to dialysis. Some successful cases for homozygous FH patients undergo a liver transplant in order to normalize LDL levels, but homozygous FH is still harder to be treated. Therefore the nutrition therapy (lower cholesterol foods) is very important for the FH patients to focus on, which can manage the healthy lifestyle to avoid the bad cholesterol was

A higher level of fats in the body puts the patient at higher risk for Cardiovascular diseases(CAD). The patient's' family has a history of CAD. Her mom and one of her sister have CAD (Lewis et al., 2014, pp. 733-734). The patient states that she has been taking her meds for cholesterol atorvastatin regularly. Her lipase level was 8272 on 11/11/16 and 2829 on 11/12/16 U/L 1069 on 11/13/16 (Ref range 73-393 U/L). Her HDL cholesterol level was 21 ( ref range>49 mg/dl), LDL Cholesterol level 148 ( ref range: <130 mg/dL). Patient statin drug was on hold because it is contradicted on the patient with an elevated level of ALT 80, 61(Ref range 0-50 U/L) and AST 61 on 11/12/16 and 64 on 11/13/16 (ref range 0-45 U/L). The uncontrolled level of could be the cause of concern for stroke or acute myocardial

Fluorescein dye has been used for a very long time and it serves many purposes within the lab and in everyday life. As a product fluorescein appears to be a brownish-orange powder solid that appears to be bright, neon green under a UV lamp. Fluorescein, Yellow No.7 dye, is used as a color addictive to food, medications, and beauty products.2 It is also used as a fluorescent tag for labeling antibodies that will be targeting specific areas of a cell1 or identify and locate life threating thrombotic emboli.4 Green Chemistry is being used in order to prevent the creation of waste products. Creating less waste will have a positive effect on the environment.

The two most common methods to gathering data utilized by the researchers in the various FH studies either employed direct data collection, such as from medical records from their visits with physicians or while they are inpatient in a hospital, or the researchers would change some aspect of the person’s life and then collect pertinent data over a set time period. The independent variables that these studies focused on included hypertensive meds, antidiabetic meds, lipid-lowering meds, statins, intestinal cholesterol absorption inhibitors, prescription omega 3 fatty acids, and antiplatelet agents that the patients were put on by their physicians, along with an isocaloric diet created specifically for that particular study, the IV injected solution for the lipoprotein turnover studies, and the lard-based diet. The dependent variables that have been studied thus far include the degree of stenosis, stroke severity, functional outcome, LDL particle size, the lipid profile variables including total cholesterol, LDL, and HDL measurement, catabolic rate of LDL, plasma triglyceride concentrations, LDL receptor activity, and sterol excretion.