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Fluid Responsiveness Study

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Introduction Prediction of fluid responsiveness has been investigated to prevent fluid overload because excessive peri-operative fluid administration can be a contributory factor to postoperative complications, prolonged length of hospital stay, organ failure and mortality1-4. Mini-fluid challenge is a strategy to assess fluid responsiveness based on a fractional change in stroke volume (SVfc) after a small loading dose of fluid. Theoretically, at a steep portion of the Frank-Starling curve, SVfc after fluid loading would be greater than at a plateau portion. Therefore, greater SVfc after small fluid loading could indicate positive fluid responsiveness. Several studies have shown that a mini-fluid challenge could predict fluid responsiveness …show more content…

The administration of a small amount of fluid is thought to have minimum adverse effects in even non-responders. Muller et al reported that a rapid administration of 100 mL fluid induced a greater than 10% increase of subaortic VTI by Doppler echocardiography, which subsequently predicted a 15% increase in VTI after a 500 mL of fluid administration in mechanically ventilated and sedated ICU patients with acute circulatory failure5. Guinot et al demonstrated a greater than 7% SVfc measured by thoracic impedance cardiography after 100 mL of fluid administration was a good predictor of a subsequent increase in SVfc in response to a 500 mL fluid loading in spontaneously breathing patients under spinal anaesthesia6. Therefore, the mini-fluid challenge can be a clinically useful diagnostic method to predict fluid responsiveness in either mechanically or spontaneously ventilated patients. The present study also showed the relatively high (r = 0.77) correlation coefficient between SVfc3 and SVfc10, suggesting that the greater the increase in SVfc3, the better the fluid responsiveness. SVfc3 greater than 5.8% measured by transthoracic echocardiography also predicted fluid responsiveness in mechanically ventilated anaesthetised dogs. All these results support the ability of the mini-fluid challenge to predict fluid responsiveness based on SVfc. However, the assessment of SVfc is challenging in routine practice because it requires special and expensive equipment. Therefore, an alternative simple method to assess SVfc would be

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