The above study (Zalesky et al., 2015) investigated whether adolescents with childhood-onset schizophrenia (COS) and their unaffected siblings displayed abnormal development of corticocortical connections compared with healthy controls. The authors hypothesised that patients with COS and, to a lesser extent, their unaffected siblings would display delays in cortical connectivity development. They further hypothesised that these delays would be greater in COS compared with the adult-onset disorder. Corticocortical connectivity between cortical region pairs was mapped prospectively, on average, every two years from 12 to 24 years of age using brain magnetic resonance imaging. Significant left-hemisphere occipitotemporal development …show more content…
Additionally, much of the research into abnormal brain connections in schizophrenia is cross-sectional. As such, the aforementioned study is of significance due to its longitudinal design which allows for neural developmental trajectories in COS to be assessed. The findings contribute to the evidence in support of the neurodevelopmental model of schizophrenia, a model which is debated (Gross & Huber, 2008; Rapoport, Addington, Frangou, & Psych, 2005; Fatemi & Folsom, 2009; Horváth, & Mirnics, 2014). However, it may be the case that COS is a neurodevelopmental sub-type of schizophrenia that is distinct to the typical adult-onset schizophrenia (AOS), which has an average onset age in late adolescence or early twenties (Häfner et al., 1994). Supporting this assertion are the differences seen between COS and AOS. For example, a higher frequency of rare alleles are found in COS compared with AOS (Asarnow & Forsyth, 2013), progressive ventricular enlargement is more consistently found in COS compared with AOS (Rapoport et al., 1997), as well as a lack of paralleled gender differences between COS and AOS. Thus, it cannot be assumed that the findings by Zalesky et al. (2015) will generalise to AOS, as the authors (at times) seem to suggest. Perhaps a similar prospective study could be conducted on individuals who develop schizophrenia during the
Expert’s reason that unevenness in the complicated interconnected chemical responses of the brain connecting the neurotransmitters dopamine and glutamate, and maybe others, performs a part in schizophrenia. Neurotransmitters are elements that permit brain cells to interconnect with each other. Experts are acquiring more about brain chemistry and its connection to schizophrenia. Similarly, in small methods the brains of people with schizophrenia appear diverse than those of healthful people. For instance, fluid-filled holes at the middle of the brain, called ventricles, are greater in certain people with schizophrenia. The brains of people with the disorder similarly manage to have less grey matter, and certain
The prevalence of schizophrenia is thought to be about 1% of the population around the world. The disorder is considered to be one of the top ten causes of long-term disability worldwide. Late adolescence and early adulthood are periods for the onset of schizophrenia. In 40% of men and 23% of women diagnosed with schizophrenia, the condition manifested before the age of 19 (Addington, Cadenhead, Cannon, 2007).These are critical years in a young adult’s social and vocational development.
Parents are ultimately responsible in their choice to have children. However, the roles that those parents have in shaping the lives of their children is entirely up for debate. There is no set guide for how you raise your children. As a result, we see a wide range of involvement from smothering to entirely absent. In Steinbeck’s magnum opus East of Eden, the influence of father figures on Adam Trask as well as the resulting effects on Adam’s children is explored. The figures in his life only serve as guiding hands, but the choices he makes are his to make freely.
A Comparison of Biological and Psychological Explanations of Schizophrenia Both the biological and the psychological explanations of schizophrenia are supported by empirical evidence which justify their explanations. However ,within the biological explanation there is the genetic explanation which is used largely based on scientific research such as that of Gottesman’s research using meta-analysis which looked at the family (including twin) relationships and concordance rates of schizophrenia. The studies used Gottesman’s research was scientifically based and because of the large number of studies and therefore the sample used, the biological research can be credited for being representative.
Schizophrenia is a brain disease. Many studies have been conducted regarding the brain localization of schizophrenia. One study established that schizophrenia is characterized by significant loss in the grey matter of the brain. The loss was detected to be up to 25% in some areas and the damage was seen to begin at the parietal (outer) regions of the brain then spreading to the rest of the regions of the brain over a period of about five years ADDIN EN.CITE Rajagopalan1998923(Rajagopalan, MacBeth, & Varma, 1998)92392317Rajagopalan, MMacBeth, RVarma, SLXXY chromosome anomaly and schizophreniaAmerican Journal Medical GeneticsAmerican Journal Medical Genetics64-65811998( HYPERLINK l "_ENREF_9" o "Rajagopalan, 1998 #923" Rajagopalan, MacBeth, & Varma, 1998). Another study showed that patients who had the worst loss of brain tissue also exhibited the worst symptoms of schizophrenia such as hallucinations, psychotic and bizarre thoughts, hearing voices, depression and delusion ADDIN EN.CITE Conklin2002797(Conklin & Iacono, 2002)79779717Conklin, Heather M.Iacono, William G.Schizophrenia: A Neurodevelopmental PerspectiveCurrent Directions in Psychological ScienceCurrent Directions in Psychological Science33-371112002Sage Publications, Inc. on behalf of Association for Psychological Science09637214http://www.jstor.org/stable/20182759( HYPERLINK l "_ENREF_2" o "Conklin, 2002 #797" Conklin & Iacono, 2002).
In the article, Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study1 published in the American Journal of Psychiatry, the authors decided to investigate the characteristic progressive brain loss that occurs in schizophrenia patients. In particular, they are testing the idea that this progressive brain loss is the result of the brain aging more rapidly in individuals affected by schizophrenia than in unaffected individuals. Schizophrenia is a very rare disease that manifest in several different ways and in different severities. Schizophrenia is often associated with symptoms such as paranoia, hallucinations, delusions, and disorganization in behavior and thinking. The cause of schizophrenia is not known
The brain is composed of mostly grey and white matter. Grey matter contains most of the neuronal connections for the brain. It can be found on the outer surface of the cerebellum and around the spinal cord. “Observations have been made of reductions in the size and total neuron numbers, but not in neuronal density,” (Höistad, 2009, p. 3). This is an outstanding discovery when analyzing schizophrenia. White matter contains many neurons as well. Researchers pay close attention to these neurons and the myelination of the axons. “Interstitial white matter neurons have been found to be increased in prefrontal white matter and temporal white matter in subjects with schizophrenia, supporting further the presence of a neurodevelopmental abnormality in schizophrenia,” (Höistad, 2009, p. 3). This means that they white matter neurons never became myelinated and mature in parts of the brain. Problems like these can mess with the connections in the brain between neurons. Research like this highlight schizophrenia as being a developmental disorder of the brian, but more research is being done including other areas as well. “The pruning of axonal connections during brain development and maturation may be necessary for adequate formation of appropriate neuronal circuits,” (Höistad, 2009, p.
Biological theorists believe that individuals may have a genetic predisposition for the schizophrenia if a close family member has been diagnosed with the disorder. Stress during adolescent years seems to provoke the disorder among individuals who have a family history of the disorder. In addition, this theory suggests biochemical abnormalities related to the dopamine neurotransmitters may also contribute to the illness as the brains neurotransmission of the dopamine is too frequent in occurrence (Comer, 2005). CAT and MRI scans have also indicated that abnormal brain structuring may also play a role in the development of schizophrenia due to a common occurrence of enlarged ventricles within schizophrenia sufferers (Comer, 2005). Various parts of the brain may not develop for function properly which seems lead to Type II schizophrenia. Studies have also pointed towards the idea that exposure to certain viruses before birth may lead to the eventual development of schizophrenia (Comer, 2005).
In the movie 10 Things I Hate About You film is a romantic drama film that was released in 1999. This film proves that there are good guys out in the world for many good girls. This move is taken place in a nice town and begins at a high school with a group of students that are in their last year of high school. In this film it shows how your normal high school students go through certain situations. Also, this film shows how many young people going through peer pressure, rejection, and romantic moments.
The two-hit model of schizophrenia proposes that disturbances to central nervous system development, leaves a person exposed to the onset of schizophrenia symptoms caused by various gene-environmental interactions. The disturbances to central nervous system development are the first hit in the two-hit model, and the gene-environmental interactions that are able to cause the onset of schizophrenia in conjunction with the disturbances to central nervous system development are the second hit in the two-hit model.
Schizophrenia is a mental illness which affects millions of people throughout the world. Scientists have begun to understand more and more about the possible causes, predisposing factors, types, and possible treatments for schizophrenia. (Torrey, 1995) It is very rare for schizophrenic symptoms to appear before the age of 12 but it does occur. Recently, there has been a growing interest in childhood schizophrenia. It is less than one-sixtieth as common as the adult-onset type but the characteristics are very similar. Childhood schizophrenia also tends to be harder to treat and to have a worse prognosis than the adult-onset form. (Rapoport, 1997)
I believe "loving" is the essential characteristic that an ultimate foster parent needs to demonstrate. When parents take time to listen and to give an explanation for matters to their child, they're competent to comprehend. This creates an environment that's safe from any emotional, intellectual or physical damage. Furthermore, an ideal foster parent should practice being a positive role model. They should be shrewd in their words and actions. They should attempt to specific their wants in a positive way. An ideal foster parent should also exhibit moral and spiritual responsibility. They should let their child transform into who they genuinely is then attempting to make the kid into the person they want the child to be. They should reliably
The goal of this case study is to provide a basis on children 's neurological development of schizophrenia including family history, genetics, environment and culture to determine the major biomedical aspects of the etiology of schizophrenia in young to middle adulthood. The study addresses the debilitating positive and negative symptoms of schizophrenics plus presenting problems, such as living life according to unacceptable social norms, and caring for one’s basic needs, while including assessment tools and diagnostic scales of childhood schizophrenia in Jack according to the American Psychiatric Association’s Diagnostic Manual of Mental Disorders, Fifth Edition. A comprehensive treatment plan assesses the outcomes of the most successful
The factors that can help predict schizophrenia in adolescents who are at high risk of developing the disorder include isolation and withdrawal from others, unusual thoughts and suspicions, and a family history of psychosis. It is important for them to learn about these symptoms since according to a study conducted by Hans, Auerbach, Styr, & Marcus (2004), people who have a parent with schizophrenia are at risk for developing schizophrenia before even reaching adulthood. The study found that males are 11.2 times more likely to develop schizophrenia than females (Hans et al., 2004). Besides being at risk for schizophrenia, the children of schizophrenic parents have a higher risk for developing personality disorders. The study also found a relationship between a parent having schizophrenia and offspring having an anxiety disorder. It is important for offspring that do have an anxiety disorder to receive the support they
Conclusions / Results: Conclusions suggest that the nature vs nurture dichotomy may not be as relevant as looking at the interaction between these two forces. It was discovered that while one’s genetic heritage creates a predisposition towards schizophrenia, other factors such as the home environment, the parental environment, dietary factors and others may determine whether the disease is manifested.