When injury occurs, the body goes through different phases in order to complete its recovery, each phase has a specific job with the intention of preparing the body for the next phase of recovery. The phases that the body goes through are; the bleeding phase, the inflammatory phase, the proliferation phase and the remodelling phase, each of these phases happen at a specific time within the recovery after the injury. The phase that this essay is going to look at is the inflammatory phase and what role the inflammation has in tissue healing whilst briefly discussing what impacts it will have in a clinical setting.
“Inflammation is a nonspecific, defensive response of the body to tissue damage” says J.Tortora & Derrickson (2011), it is an effort
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The neutrophils are attracted by fibronectine and growth factors which leads to them performing their role of phagocytosis. Phagocytosis allows the neutrophils to engulf all the debris and bacteria that are in and surround the site therefore getting rid of foreign particles and allow a clean environment for the inflammation to being to happen. As a result of the phagocytosis happening this then leads to macrophages replacing neutrophils which come from immature monocytes which are stored in spleen, they secrete growth factors and cytokines which lead onto the next phase of the healing response which is the proliferation phase (Frederic H. Martni, Judi L. Natch, Edwin F. Bartholomew, 2014).
The role of inflammation in tissue healing is to help to promote healing and create an environment around the injured area that is optimal for the best healing time and for the best healing process to take place. In order to complete this the body must remain in a balanced homeostasis, this being a level at which the bodies temperature, blood pH and water balance are constant. Remaining at a balanced homeostasis will mean that the inflammatory response is able to work effectively as it has the right conditions in which to perform at its
Physiological responses: damaged tissue, eg primary damage response, healing response, the clotting mechanism; the importance of scar tissue control in the re-modelling process; specific to injury, eg sprain/ strain (signs and symptoms of first, second and third degree), haematomas (inter/intra)
Protein is obviously what everyone’s body part is made up of protein and so the fibrous tissue which is result to healing if low protein this tissue is not synthesized and high protein can increase it rates. Carbohydrates, as they are provide the main structural materials required for growth, repair, and maintenance of tissue. A&P 9th ed. Pg.50
Fluid building up in the tissues caused by an inflammation response, triggered by the repeated stresses on the tissues, can lead to maceration of the deeper tissues, resulting in wounds and ulcers. Especially in patients with limited healing due to circulation conditions and diabetes, or those suffering peripheral neuropathy (Fig 3)
Cytokines, like histamine and leukotrienes, are secreted by damaged cells in Dave’s ankle. How do these cytokines
Proliferative phase occurs within a few days of injury in which cells that were involved in the battle need to tend to their wounds and the regenerate to restore itself to its formal glory as best as possible. The body’s way of restoring itself is through use of angiogenesis, granulation tissue formation, wound contraction and epithelialization. This combination acts of getting new blood vessels to the damage area, aid in the formation of cells to fill in the area which leads to scar tissue, allow the skin to flexible in the repair process and finally resurface the wound with new epithelial
The inflammation reaction to a skin cut is beneficial. When we have a skin cut or a trauma to the skin. Inflammation is a mechanism of defense; the body will release chemicals like histamine to promote capillary permeability and will increase the number of white blood cells to fight pathogens. This process will lead to healing the wound.
Skin repair is an important physiological process which is essential for homeostasis, restoring barrier function and preventing infection (Martin, 2009; Boateng and Catanzano, 2015). Wound healing is defined as a complex, dynamic and the specific biological process associated with the phenomena of tissue regeneration and growth (Mazumder et al., 2016). Regeneration can be defined as a tissue that significantly damaged either completely or partially removed and tissue's original function and cell types must be functional and structurally restored (Mazumder et al., 2016). The process of healing comprises a cytokine, blood cells, extracellular matrix and growth factor (Joao De Masi et al., 2016). The growth factor is a protein that activates and
Stechmiller, J. K. (2010). Understanding the Role of Nutrition and Wound Healing. Nutrition in Clinical Practice, 25(1), 61-68. doi:10.1177/0884533609358997
Fibroblasts are mesenchymal cells that play an important role in the wound healing process. These cells are responsible for releasing inflammatory agents that recruit white blood cells to areas of damaged tissue. Fibroblasts also respond to these chemicals and differentiate into myofibroblasts. These myofibroblasts are characterized by their up-regulated rate of extracellular matrix component production and their ability to physically manipulate the extracellular matrix. When the wound healing process becomes unregulated, this results in what is referred to as a fibrotic response (Kendall). As a result fibrosis, or the thickening and scarring of connective tissues, occurs. Fibrosis is the excess deposition of ECM components like collagen and
For example, the signs and symptoms of wound infection could be confused with the inflammatory phase, while parts of the wound may be in the destructive phase, with other parts in the proliferative phase. Nevertheless, to recognise that the complex physiological process can be divided into distinct phases from the initial emergency response to injury through a process of repair and regeneration to complete healing helps the nurse in the clinical decision-making process.
Inflammation is a natural body reaction in response to infection or tissue injury, which helps man to
Also Cytokines an be secreted by a variety of cells including neutrophils, activated macrophages, fibroblasts, endothelial cells and damaged muscle cells. The physiological response to tissue injury is inflammation, which involves the production of cytokines. .These soluble molecules will enhance the arrival of neutrophils, monocytes and lymphocytes to the damaged muscle tissue. Cytokine ruesponse depends on type of exercise, intensity, duration, recovery between exercise bouts and training status. cytokines is playing a significant role in both destruction and repair processes on damaged tissues. Some data reported that when IL-6 is secreted by muscle, it has been shown that it increases anti-inflammatory cytokines such as IL-10 and IL-1ra (Powers, 2012, Calle, M.,& Luz, F.,
Inflammation normally occurs as a second response when damage tissues. Inflammation can occur immediately however
What is Inflammation? There are two types of inflammation, acute inflammation and chronic inflammation. Acute inflammation is a good inflammation, it helps the body heal after the immune cells and nutrients destroy the bacteria and repair the damage tissue. Chronic inflammation is the bad inflammation, it comes when the body is not able to heal itself properly. It is also brought on by our immune system being overstressed or over exposure to the unhealed wound. A lot of foods like white bread, French fries, red meat and margarine are another