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Essay on Drugs and Bronchospasms

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Drugs and Bronchospasms

Bronchospasms induced by drugs can be managed beneficially through knowledge of causative agents and knowledge on treatment of the disease. Bronchospasms are "an excessive and prolonged contraction of the smooth muscle of the bronchi and bronchioles, resulting in an acute narrowing and obstruction of the respiratory airway. The contractions may be localized or general and may be caused by irritation or injury to the respiratory mucosa, infections, or allergies or drugs. A cough with generalized wheezing usually indicates the condition. Bronchospasm is a chief characteristic of asthma"2 and Chronic Obstructive Pulmonary Disorder (COPD).
"Asthma is a common chronic disease worldwide and affects approximately 24 …show more content…

Aspirin induce bronchospasms prevalence is 0.6 - 44% overall and 21.1% in asthmatic patients and 29.9 % in patients with a previous incident of aspirin induced bronchospasm. 5 The wide range is due to patients without a history of asthma or Aspirin induced asthma being less prone while patients with a history if asthma being more apt to aspirin induced bronchospasms especially patients with asthma and nasal polyps.5 NSAIDs like ibuprofen, naproxen, and diclofenac (strong cyclooxygenase inhibitors) have reported cross sensitivities in aspirin intolerant patients of 98%, 100%, 93% respectively.5 However, low inhibitors ( acetaminophen) and non-inhibitors( meloxicam) of cyclooxygenase 1 are better tolerated in patients with cross sensitivity6 ;and only tend to induce bronchospasms at

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