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Does Dysfunction Of The Prefrontal Cortex Lead Antisocial Behavior?

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Student ID number: 1704918

Does dysfunction of the prefrontal cortex lead to antisocial behaviour?

Word count: 984 Antisocial behaviour (ASB) broadly encompasses human character traits and behaviours that are generally viewed as unpleasant or immoral, such as reduced empathy, aggression and violence. Consequently, ASB is unconducive to forming healthy interpersonal relationships and functional living and on a large scale is socio-economically detrimental to societies. Therefore, research into ASB’s aetiology is important for potentially informing its prevention and management and in turn reducing its negative outcomes. This essay investigates the possible causal role of prefrontal cortex (PFC) dysfunction and structural abnormalities in ASB, focusing on specific PFC subregions; as well as the roles of other brain regions, genetics and the environment. It argues that there is significant evidence that the dysfunction of several brain regions, including the PFC and areas of other lobes, can lead to ASB. The underlying reason(s) for the dysfunction may be brain damage and/or genetic and environmental influences.

The PFC, the rostralmost region of the frontal lobe, as part of neural circuits that include other cortical and subcortical regions, is widely regarded as the neural substrate for many executive functions (EFs), at least some of which are impaired in ASB. EFs include working memory, planning, decision-making and inhibition (Eslinger,

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