During the First World War, the French coalition began integrating 2, 4-Dinitrophenol (DNP), as well as other nitro compounds, into their explosives.4 Since its induction, DNP has been used in several practices, ranging from wood preservation, photography development, herbicide, and dyes. In 1933, Maurice Tainter, a Stanford pharmacologist, discovered that DNP had commercial value and potency as a weight loss drug.6 Upon investigating its aromatic structure, and discovering that its interaction with cellular components was responsible for energy and heat production, Maurice was able to prove his hypothesis and confirmed that human consumption, of a previously incorporated additive in explosives and herbicides, led to substantial weight …show more content…
Bachynsky was able to market his product as “Mitcal,” and converted his practice into a weight loss clinic.1 He gained much attention and publicized his drug as an integral component in his new technique called “intracellular hyperthermia therapy.” However, when several thousands of patients reported similar symptoms as the DNP crisis, and news of “Mitcal” intentional overdose, the FDA opened an investigation of Dr. Bachynsky and his practice in 1983.5 Upon further investigation, and uncovering the key component in “Mitcal” and “intracellular therapy,” Bachynsky was convicted of drug violations, penalized, and prohibited from practicing medicine or prescribing DNP to others in 1986.6 Nonetheless, this was not enough to quell Bachynsky’s dubious methods of dispensing DNP. He later evolved and discovered novel avenues to market DNP, claiming that DNP had other potent “medicine value.” Bachynsky moved his methods and practice overseas, where he fostered a marketing relationship with an establishment in Europe that was developing DNP.3 He successfully marketed his “intracellular hyperthermia therapy,” targeted to cancer patients. However, Bachynsky was discovered and incarcerated in 2008 on fraudulent accounts.1 Since then DNP has mainly been prominent in the media, specifically in the bodybuilding and rapid weight loss avenues. There have been a plethora of case involving individuals who has attempted to take DNP, with intention of losing weight and
“Every project has a beginning and an end” (Zaccagnini & White, 2014, pp. 455). Previous chapters have discussed the closure of the project and the need for a formal evaluation of the project’s impact on the organization in which it was implemented. The most significant reasoning behind the formal evaluation process of the DNP project is the need for translation of learned knowledge to practice (Zaccagnini & White, 2014). Translation science is an essential part of the overall reasoning behind the project, but the stakeholders involved must be provided the information and subsequent recommendations for further improvement within their organization (Zaccagnini & White, 2014). This chapter discusses the various data and how they are interpreted. Project recommendations are evaluated, acknowledging the interpretation of the data, to determine how the project interventions made an
Many drugs have been used in the MKULTRA experiments including “mustard and nerve gas, riot-control agents, LSD, PCP, mescaline, and hundreds of other chemicals, including many that had been rejected by manufacturers for commercial use because they contained deadly poisons, such as dioxin.”(Linda
In order to have better understanding, data from the manufacturers is reviewed below which will also show whether the manufacturers of these products behaved ethically as well as what needs to be reconsider with respect to the use of incretin-based therapies because of the growing concern of potential risk of AP. Hence risk management plans will be discussed below. (Butler et al, 2013)
BIO Full Board of Directors Board Book – This Book contains an agenda and background materials with respect to the action and discussion items for the Full BIO Board meeting scheduled from 5:00 pm – 6:00 pm in the Oriental B/C Ballroom at the Mandarin Oriental hotel on December 8. Please note that directly following the Full Board meeting, all Board members are invited to attend a Panel Discussion on Drug Value/Policy Proposals from 6:00 pm – 7:15 pm. Guest speakers will be Sam Nussbaum and Adam Fein.
The “Cold Feet” dilemma had seven people that would be affected by my decision: The shareholders, the Chief Legal Officer, the Marketing Director, the Division Medical Director, the National Institute of Health, the future purchasers of the drug, and the Journal. The reputation lens and the relationship lens were used to help me make a decision. The relationship lens helped me identify that people involved are entitled to a number of limited rights, people without power must be protected, and the right to a fair process. This led me to choose to have a committee with the appropriate authority and representation
He illustrates all the wrong doings of the pharmaceutical companies from their unethical ‘standard company sales pitch’ to their ‘deadly drug.’ He also shed light on all those who were on the brink of discovery on the drugs deadly secrete. Dr Leslie Florence published a paper linking thalidomide to nerve damage in 1960 followed by an interview some 51 years later. After inserts of evidence in the past tense he refers back to the trial in the present tense continuing the narrative. The structure of his writing follows a narrative rather than a diary or catalogue.
According to Ghillyer (2014), medications and drugs have many uses that are often not approved by the Federal Drug Administration. In 2012 Abbott Laboratories were involved in a lawsuit related to illegal marketing. The company promoted a medication to control and treat agitation, aggression, and schizophrenia. The medication had only been approved for treatment of seizures, migraines, and bipolar mania. GlaxoKline-Smith was also involved in a settlement regarding off-label promotions for marketing Wellbutrin for weight loss, sexual dysfunction, substance addiction, and behavioral
One of the interesting things I have learned from Ben Goldacre’s Bad Science is how significant it is to know the difference between science and pseudoscience. As Goldacre discusses, most people see science as an authority not a method (Goldacre, page 3); so they mistakenly confuse market-based pseudoscientific products with science. Science is about experimental methods and testing specific hypothesis by controlling conditions to see the effects of studied factors. Pseudoscience, in contrast, ignores experimental methods, takes advantage of the science name, and justify its findings by shifting into untestable positions (Goldacre, page 7). The emergence of detox products (Goldacre, page 4), brain gym (Goldacre, page 15), homeopathy (Goldacre, page 30) and other types of alternative therapies are good examples. One key point here is the importance of experimental methods. One way to find out the basic of science, we need to disprove pseudoscientific claims (Goldacre, page 3) and it is done thorough experimental methods.
One of the many advancements made during the duration of World War I was that of poisonous gasses. These gasses were considered “uncivilized” before the beginning of the first World War. However, they were deemed necessary to overcome the standoff between the Allied forces and the Central Powers. The French army was the first to use such a weapon in 1914, but the Germans were the first to use poisonous gasses on a large scale. The German’s first recorded use of
In the first of two court cases between 1950 and 1962, the courts ordered Mytinger & Casselberry, Inc. to change their claims of Nutrilite vitamins positively aeffecting diseases like cancer, arthritis, asthma, heart trouble and tuberculosis. They changed their sales booklet, but most of the claims in the booklet was were still very misleading. After the FDA went on a rampage to seize as many of Nutrilite’s products as possible to force them to correct their misleading info or face going to court, Mytinger & Casselberry filed suit against the FDA, stating through the seizures they are trying to run them out of business, before they could make the necessary corrections, i. In a fairly lucky twist theirir the Judge in their case Judge Goldsborough, who was very much against the FDA, found in favor of Mytinger & Casselberry and issued a restraining order against the FDA, they went to trial and on
They deceived them for 40 years by making them think they were receiving treatments for “bad blood” when in fact they were withholding treatment. However, in present day, researchers must comply with guidelines and undergo a review panel to be approved. Participants must be informed of the study and its risks as well as the right to decline participation at any given time. The subjects must also be competent and be able to understand what is happening in the experiment as well as its
Joseph Knoll, professor and head of the Pharmacological Department of the Semmelweis University in Budapest (Hungary), developed (-)Deprenyl in the 1960s.
In February of 2015 the Federal Trade Commission issued refunds to 11,585 consumers for diet pills that were labeled as “fat burning” and “calorie blocking.” A Quebec based marketing group ran by Manon Fernet falsely claimed that the “Double Shot” pill would cause rapid, substantial and permanent weight loss, without diet or exercise; the FTC refund totaled to $464,000. According to the case after further investigation the Commission vote authorizing the staff to file the complaint and approving the proposed settlement order was
There were of course marketing and advertising campaigns launched by the drug companies producing this product that touted these narcotics as the cure for all types of physical and mental ailments ranging from alcohol withdrawal to cancer, depression, sluggishness, coughs, colds, tuberculosis and even old age. Most of the elixirs pitched by the old “snake oil salesmen” in their medicine shows contained one or more of these narcotics in their mix.
1. Naphthalene is a white organic solid compound with a distinctive odor (ATSDR, 2005). Numerous results from the animal studies showed that naphthalene is potentially considered to be a human carcinogen. The studied indicated the fast absorption of naphthalene by inhalation, oral and dermal administration (22-73%; up to 84%; 50% respectively) (Preuss et al., 2003). Distribution of naphthalene occurs at fairly rapid rate without significant accumulation in body tissues (Preuss et al., 2003). Once absorbed, naphthalene undergoes metabolic activation and conjugation (Preuss et al., 2003). Naphthalene metabolites such as naphthoquinones prompt reactive oxygen species production that ultimately leads to DNA damage and carcinogenic transition of cells (Preuss et al., 2003). The US National Toxicology Program (NTP) reports indicate the results from long-term inhalation study conducted on rats that showed notably increased incidence of lung and nasal tumours (Preuss et al., 2003). Despite of the lack of human studies, the findings of the NTP allowed to admit naphthalene as a potential human carcinogen (Preuss et