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Diabetic Foot Ulcer

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INTRODUCTION Roughly 25% of diabetic patients experience Diabetic foot ulcer infection during their lifetime due to poor blood glucose control. Diabetes mellitus is a major non-communicable diseases and public health problem [1]. According to the International diabetes federation, approximately 69.2 million people affected nationwide and worldwide 415 million people having diabetes [2]. The risk factors of foot ulcer are 10 times more predominant in diabetic patients as compared to without having diabetes [3]. Foot ulcer infection in patients with one or more of this risk factor which help to the development of wounds that can be poor to heal and predispose to other infection. Diabetes is the complex disease in which various factors such as …show more content…

Most common among them are extracellular polymeric, biofilms production by bacteria that may lead to multidrug resistance in pathogens. The Biofilms formation in foot ulcer leads to ineffective penetration of antibiotics due to render of leukocytes into the ulcers by developing antiphagocytic properties inside the biofilm matrix. The matrices formed by bacteria in the biofilms can facilitate altered gene expression, intercellular communication and horizontal gene transfer. Furthermore, peripheral arterial diseases are often present in patients with foot ulcers infection and may lead to poor penetration of antibiotics into the lower limb tissues, thereby promoting selection of resistant bacteria strains. More than 90% strains in Acinetobacter baumannii were resistant to all beta-lactams, fluoroquinolones, aminoglycosides antibiotics [11]. Alternatively, treatment to heal foot ulcer antibiotic were colistin, polymyxin B, tigecycline [12]. Therefore, the present investigation was done in order to study the prevalence, and antibiotic resistance pattern and biofilm formation of Acinetobacter baumannii strains in Diabetic and non-diabetic foot ulcer

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