Colorectal cancer is the third most common cancer among men and women in the United States, and mutations in the MUTYH gene significantly increase the risk of developing polyps that may evolve into cancer.1,2 Biallelic mutations in the MUTYH gene can lead to MYH-Associated Polyposis (MAP), which causes the growth of dozens to hundreds of polyps, furthering increasing the risk for colon cancer.2 Meanwhile, recent studies have shown that both biallelic and monoallelic mutations can contribute to bladder, ovarian, gastric, hepatobiliary, endometrial, and breast cancer.3 The MUTYH gene itself codes for the MYH glycosylase enzyme, which repairs mistakes in DNA caused by reactive oxygen species.3,4 Also a sign of oxidative stress, the oxidation product, 8-oxo-7,8-dihydro-2-deoxyguanosine (OG), mimics thymine, eventually matching with adenine and resulting in a complete loss of the cytosine-guanine pair.4 MUTYH removes the undamaged A base from the mismatched pair, aiding in the correction of such damage.4 However, when MUTYH is mutated, there is an increase in G to T mutations, which can eventually affect the tumor suppressor genes APC and K-ras and lead to tumor formation.4 The MUTYH variants Y165C and G382D are the most common mutations seen in individuals with MAP, and for this reason are of great interest in research working towards reducing the risk of colorectal cancer.2,4 In recent years, the CRISPR/Cas system for gene editing has become the preferred method for
Mr BW was a 74-year-old man who had a fall due to a new onset of seizures, which resulted, to a direct impact of his head on the ground while at home. While at the hospital, MR BW underwent a CT and MRI brain scan and showed a haematoma, which resulted to commencing of the patient on Keppra and Bezodiapenes. Moreover, Mr BW also developed a sudden onset of pleuretic chest pain, which was confirmed by CTPA as a small pleural effusion on the left lungs; while there was also pulmonary embolism on both upper and lower lobes of the left lung. Due to the development of a provoked pulmonary embolism, patient commenced on Clexane injection. In September 2015, an elective open abdominoperineal resection was performed on Mr BW, which resulted to prolonged stay in the hospital due to delayed wound healing.
In 2000, Eloisa Casas was diagnosed with colon cancer. She went through the stages of surgery, radiation, and chemotherapy and one year later with considered to be cancer free and placed in remission. On July 10, 2001, she was addmitted to the hospital with abdominal pain, as well as a fever and an elevated white blood count, which could indicate a possible infection. Her primary physisian and surgeon, Dr. Garcia-Cantu, consulted infectious disease specialist, Dr. Jelinek, who then prescribed her Maxipime as a general antibiotic and Flagyl as an antibiotic for anaerobic bacteria on July 11.
Colorectal cancer mainly starts at colon or the rectum. They are common in most of the way like features, but they have different treatment. What is the different between colon cancer and rectum cancer? Colon cancer happens first four to five feet of the large intestine and rectal cancer happens in the last few inches of the large intestine where it is connected to anus.
There are about 35,000 new cases each year in the UK. More than 80% of
African Americans carry an uneven share of the cancer load in the United States, having the highest death rate and shortest survival of any racial or ethnic group for most cancers. In this article, I will provide updated data for African Americans on cancer rate, death, survival, and cancer screening. I also estimate the total number of deaths prevented among African Americans as a result of the decline in cancer death rates since the early 1990s.
Bowel cancer is the second leading cancer in Australia with over 90 % of whom over 50 years old (Bowel Cancer Australia, 2014). Every year, over 17,000 people are newly diagnosed with bowel cancer (Cancer Council Australia, 2015). The most common treatment for all stages of bowel cancer is removing the cancer and forming a stoma which may help people to maintain the maximum function of their digest system. Depending on the patient’s situation, the colostomy can be reversed to recover the function of absorb nutrition and exclude metabolites. This paper will review the whole process of a patient who received reversal colostomy from admission to discharge, and explain the symptoms that the patient had post operation.
There was a time I use to consider the colon as a passage for waste products. However, after reading a couple of health related articles, I found that the colon plays many roles in the body, and not just as a passage for waste products. Unfortunately, it is one of the less recognized organs in the body.
Colorectal cancer is a cancer of Colon or Rectum and sometime also referred as Bowel cancer. Majority of colorectal cancer are adenocarcinoma i.e. cancer of mucosa cell. Colorectal cancers are locally invasive in nature but metastasis is usually evident before local invasive symptoms. Clinically, colorectal cancer can be characterized into early stages i.e. stage I to III or more advance and deadly IV metastatic stage. Metastatic is the stage of colorectal cancer in which cancer spread from its origin to other parts of the body organs, particularly Liver is the most commonly affected organ and thus makes it very lethal.
Cancer is very prevalent in America. It is one of the many diseases still left without a cure. Men and women all the around world are affected by this disease as it continues to spread. There are many different types of cancer that impact both men and women such as pancreatic, lung, breast, skin, and many more types of cancer. Bailar and Gornik say that despite decades of basic and clinical research and trials of promising new therapies, cancer remains a major cause of morbidity and mortality (1997). Whether you are male or female, cancer has the ability to terminate any one’s life.
The bowel is a hollow tube within the digestive system composed of the small bowel (small intestine) and large bowel (colon and rectum). Bowel cancer generally affects the large bowel, which absorbs water from digested food and then produces waste (Cancer research UK, 2014). Bowel cancer, also known as colorectal cancer, develops from uncontrollable cell division of polyps, pre-cancerous growth cells, which cause potential harm within the bowel (Bowel cancer UK, 2016). Bowel cancer is treatable and curable if diagnosed early; nevertheless, by simply adopting healthier changes to your lifestyle, two-thirds of cases could be prevented (Cancer research UK, 2010).
Colorectal cancer affects colon and rectum. Also it occurs in the large intestine. When the cancer is in the last six inches of the rectum, it is known as a rectal cancer. Additionally, colon is in the lower part of the digestive system that processes food and rides the body of waste. Simultaneously, these are referred to as colorectal cancer. Colorectal cancer (CRC) is the most common disease in our society that kills men and women. It is ranked the third most common cause of death among the African American men and women in the United States of America. In addition, colorectal cancer is caused by ulcerative colitis, certain types of diets such as diets that are high in red meat, obesity, smoking, alcohol abuse, and poor exercise. Also, colorectal
National Colorectal Cancer Awareness Month is used to bring awareness to one of many cancers that affects 1 in every 100 person, health wise. Although colorectal cancer can be preventable, it is among the list of cancers that affect both men and women. As one of the second leading causes of cancer deaths in the United States, colorectal cancer affects approximately 140,000 Americans who are diagnosed each year, leaving more than 50,000 people die from it. According to the Prevent Cancer Foundation, the list below are ways to prevent this cancer:
Colorectal cancer mainly starts at colon or the rectum. They are common in most of the way like features, but they have different treatment. What is the different between colon cancer and rectal cancer? Colon cancer happens first four to five feet of the large intestine and rectal cancer happens in the last few inches of the large intestine where it is connected to anus. (cancercenter.com)
Colon cancer claims the lives of 12 Australians each day and is the second largest cancer killer (1). Colon cancer is one of the leading causes of cancer in the Australian population after the age of 50. It is essential that Australian men and women are aware of the aggressiveness and severity of the disease (2) and the primary preventative methods. The Indigenous Australian population, in comparison to the non-indigenous population, have a higher prevalence of the disease and experience higher mortality rates (3). Due to the lack of medical resources and awareness, men and women living in rural areas have an increased risk of developing colon cancer (4). For these reasons, I have decided to conduct an investigation on the significance, the primary preventative methods and the impact they can have on the health and awareness of the Australian population.
Colorectal cancer is one of the global leading diseases and it is the third most common causes of death in both men and women in America. Approximately 1 in 12 Australians will develop colorectal cancer in their lifetime, and according to Bowel Cancer Australia, individuals are at risk if they are aged 50 years and over, have had an inflammatory colorectal disease or significant family history of colorectal cancer polyps.