Collagen Research Paper

Also, three primary structural components of the dermis, collagen, elastin and GAGs have been the subjects of the majority of anti-aging research and efforts for aesthetic-anti-aging strategies pertaining to the skin, from “anti-wrinkle creams” to various filling agents.

58) Connective tissues that possess a large quantity of collagen fibers often provide the framework for organs such

Collagen is a form

It is made up of either liquid, solid, or connective tissue, within the matrix there are many types of connecting fibres, such as collagen and elastic fibres.

When skin has more collagen, it looks firmer and healthier. You can combine regular sessions of professional red light therapy with daily use of collagen-stimulating skin-care products, such as a vitamin C serum, for the best results.

About one quarter of all the protein in your body is collagen. It is a major structural material that forms molecular cables to strengthen the tendons and resilient sheets that support the skin and internal organs. Bones and teeth are made by adding mineral crystals to collagen. Collagen provides structure to our bodies, protecting and supporting the softer tissues and connecting them with the skeleton. But, in spite of its critical function in the body, collagen is a relatively simple protein.

Type I collagen clearly contributes to the integrity and strength of bone matrix, and defects in its production leads to bone of poor quality, susceptible to fracture( Kini and Nandeesh 2012). Type I collagen is a triple helical structure consisting of two identical a1 chains and one a2 chain with a non-helical region where the N-telopeptide and C-telopeptide join to the crosslinks (Brown et al.,2009; Bergmann et al., 2009 ; Seibel 2005). During type I collagen synthesis, pro-peptides are released both from the N-terminal and C-terminal ends of the procollagen molecule, after the three individual alpha chains have created the triple helix, which will become part of the collagen fibril( Kini and Nandeesh

With an ever increasing number of people becoming involved with athletic activities, there is an increasing number of injuries occurring which can be devastating for the individual. Most of the injuries that affect athletes occur in one of four structures in the human body: bones, muscles, tendons, or ligaments. Because ligaments attach bone to bone and play a major part in providing stability for joints, the major stabilizing ligament in the knee, the anterior cruciate ligament (ACL), assists in performing everyday actions of the human body including sitting, standing, walking, running, dancing, and participating in other sports. The injury that specifically affects this ligament is very serious and always

A majority of all Americans have participated in at least one sport during their childhood and adolescent years. Differences exist in both contact and noncontact sports, but the likelihood of sports related injuries still occur due to physicality or the overuse or misuse of a particular body part. (www.stanfordchildrens.org). With the common occurrence of injuries in every sport, recent times have brought breakthroughs that help athletes recover faster and more effectively. Since its debut in ancient times, sports medicine has been a big part of all athletes’ lives with healing and recovering. From injuries such as ACL damage, shin splints, strains and sprains, muscle cramps, and concussions, sports-related injury is inevitable for most athletes but with the help of medicines and preventative measures injury can become more and more avoidable.

The COL1A1 gene provides instruction for making part of a large molecule called type 1 collagen. Collagens are used to strengthen and support many tissues in the body such as cartilage, bone, tendon, skin, and the white part of the eye. Type 1 collagen is the most abundant form of collagen in the human body. The defect in the structure of type 1 collagen weakens connective tissues, particularly bone. This results in the characteristic features of OI. The genes CRTAP and P3H1 are genes that

(2009), a well-structured, long-term exercise, within a physiological range, does not harm the tendon but actually reinforces it, stimulating the production of new collagen fibers. When tendons are injured, the body initiates a process of healing and scar formation that can be divided into phases: 1) Hemostasis/inflammation, 2) Proliferation/fibroplasia and 3) Remodeling/maturation (Figure 1). First, collagen molecules assemble extra-cellularly in close association with the fibroblasts to form immature fibrils. Then, the fibrils assemble end to end to form longer fibrils. In a third step, fibrils associate laterally to generate large diameter fibrils (Abate et al.,

When collagen is produced using this method, the skin fills out and wrinkles diminish. One critical substance for the production of collagen in the skin is the protein, keratin. If you are serious about building collagen levels, don't bother with collagen supplements. However, it is essential that keratin be included in the creams and lotions you use.

The skeletal system is made up of cartilage and bone. Both bone and cartilage are connective tissues, that is, they are composed of cells in a matrix with intracellular fibers. Just imagine connective tissue as a gelatin salad with grapes and coconut. The grapes would represent cells, the gelatin the support material for matrix, and the pieces of coconut the intracellular fibers. By changing the amounts of each ingredient and adding extra substances, we can produce a material that is very hard like bone and can withstand weight or softer like cartilage which can be used as a cushioning material.

Connective tissue is a tissue that forms the framework and supporting structures of the body, including bone, cartilage, mucous membrane, and fat (The American Heritage student science dictionary 81). Connective tissue is in collagen (What is Collagen).Fibrous is tissue in animals that connects other tissues together (Gel well: Which additives make the strongest Gelatin).

Firstly, the understanding about the role and composition of ECM are essential to design useful biocompatible materials that can resemble the function of ECM. Tissues are not only made up of cells but part of their volume also constitute of ECM. ECM is the natural environment for cells in the body that comprised by intricate network of proteins and glycosaminoglycans (with predominant hyaluronic acid).2 The major components are collagens, non-collagenous glycoproteins (fibronectin, laminins and tenascin), hydrophilic proteogylcans and soluble macromolecules such as growth factors, chemokines and cytokines involved in cell-cell and cell-matrix interactions1-4. Collagen is the main component of connective tissues such as in bones and skins. Laminin gives cue for cell adhesion via integrin receptors whereas elastin provides elasticity and resilience to the tissues.