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Cacstromethorphan Case Studies

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1.Dextromethorphan is believed to have rapid acting antidepressant properties at high dosage because it’s similar to glutamate NMDA receptor antagonist ketamine, which has shown rapid (within hours after administration) antidepressant effects. However, ketamine has adverse effects and a high potential to be abused [16].

2.C. Previous Studies and case reports of with Dextromethorphan/Rationale of Study
Currently, numerous studies are examining the use of Dextromethorphan in the treatment of neurological and psychiatric disorders because of its’ profile and diverse pharmacokinetic and pharmacologic actions in the central nervous system. Several preclinical, open-label and blinded clinical trials have shown the clinical and beneficial …show more content…

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A case report showed Dextromethorphan was effective in a middle-aged man with Major Depressive Disorder. A 51-year–old Caucasian male with DSM-V Major Depressive Disorder, recurrent, severe, non-psychotic and Generalized Anxiety Disorder was treated with 600 mg/day of CYP2D6 inhibitor bupropion XL (a common antidepressant drug) and a 60 mg BID oral dose of Dextromethorphan. The patient showed improvement in major depressive disorder without side effects. This case study was the first to show the fast acting effect of Dextromethorphan in major depressive disorder in humans. This adds to the building literature on the antidepressant effects observed in Dextromethorphan. The report suggested the administration of other common antidepressants with Dextromethorphan, such as lithium might prolong the duration of the rapid-antidepressant effect [19].
Although this case report illustrates that Dextromethorphan has rapid antidepressant effects in humans, there are very few clinical trial on the effect of Dextromethorphan on major depressive disorder. This clinical trial will be one of very few controlled evaluating the safety and efficacy of Dextromethorphan in patients with major depressive disorder. Therefore, various assumptions will be required to estimate sample size. This trial will focus on patient who have

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