Solving Blood Platelet Banks Model Using
1 Corresponding
Introduction
A platelet is a disk-shaped structure found in the blood of all mammals, playing a major role in the coagulation of blood 1; platelets are transfused to patients to treat or prevent bleeding during surgery and other medical conditions associated with platelet deficiency or function defect. Platelets shelf life for transfusion purposes is up to six days; however, due to testing, platelets are generally not released to inventory until 24 hours after the collection time. Therefore, usable platelet shelf life is generally five days. This is an extremely short product shelf life compared to other blood products. This makes inventory management of platelets
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Whenever there is a shortage, a special
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order must be placed to look for the required blood platelets elsewhere or to look for donors. Therefore, the inventory of these blood platelets needs to be actively managed. While a patient should receive blood platelets of the same type, blood platelet substitution is possible between certain blood platelet types. The distribution of blood type at different countries are listed in Table 1 and the average demand and supply in USA is shown in Table 2. Table 3 shows all the substitution possibilities for all blood types (BloodProducts 2011)1 , where ’1’ indicates that the substitution is allowed between these two blood types, and ’0’ means that substitution is not allowed between these two blood types. Since the distribution of supply does not match with that of demand, blood centers often run short of types B and O. This, however, does not mean that supply of other blood types is abundant. Shortages of all blood types occur, especially during summer and winter holidays (USABlood 2011). In addition to blood platelet type, age of the blood platelet will also be considered in the developed model.
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Country/Blood Type Canada Finland Hong Kong USA AB+ 2.5 7 7 3 AB– 0.5 1 0.02 1 A+ 36 38 25.9 34 A– 6 6 0.08 6 B+ 7.6 15 26.9 9 Type/Blood Type Demand Supply AB+ 3 3.4 AB– 1 0.65 A+ 34 27.9 A– 6 5.17 B+ 9 11.63 3
Table 1: Blood type percentage distribution in
There are four blood types found in humans. These are A blood type which has the genotype either AA or AO, B blood type which has the genotype either BB or BO, AB blood type which has the genotype AB, and O blood type which has the genotype OO. These genotypes show a combination of complete dominance and codominance. A and B traits are dominant to the recessive O trait, however, the A trait is codominant to the B trait. Each blood type codes for certain antigens. A blood codes for the A surface antigen, B blood codes for the B surface antigen, AB blood codes for both the A and B surface antigen, and O blood does not code for a surface antigen. Therefore to determine one’s blood type a test can be performed
To explain the ABO and Rh blood groups and to identify the universal donor and the universal acceptor (recipient).
The American Red Cross and Americans Blood Center currently encompass almost all of the nation’s blood supply. Blood supply decreases more during the summer because schools and certain businesses close and are not open to hold a blood drive. The American Red Cross predicts that “a person in a single car accident can need up to 100 pints of blood” (ARC, 2016). However, during a routine blood drive a person can only donate 1 pint of their blood supply. The American Red Cross also reports that they need “80,000 units in one day to run successfully, but are only receiving 36,000 a day” (Healy, 2016).
In Cardone presentation, His main focus was on Platelet-rich plasma (PRP), (plasmas that come from the patient’s body, and is centrifuged to increase the concentration of platelets combined with remaining blood). He also discussed the potential advantages as well as potential drawbacks and uncertainties regarding the use of PRP injections to treat
This unit is aimed at health and social care professionals involved in the use of
October 17, 2009, my world changed. My little brother, Brennan, was diagnosed with idiopathic thrombocytopenia purpura, in short known as ITP. Normally, platelets are made in bone marrow and make their way through the blood stream and filtered out by the spleen. In Brennan’s case, his platelets are destroyed by his body causing his platelet count to drop to life threatening levels. Brennan’s platelet count from 2009, to today in 2016, has never gotten higher than 20,000; which means that he is at risk for spontaneous bleeding at any time. Due to this, Brennan is not allowed to participate in sports and many other physical activities.
Both texts provide great points and clearly send the message: guns should not be allowed for the public. However, Blood Drive is more persuasive due to the text being in a story format compared to a factual format. The Myth of The Good Guy with a Gun provides factual, quantitative values that represent the dangers of guns such as, “every 1 percent increase in gun ownership, there was a 1.1 percent increase in the firearm homicide rate and a 0.7 percent increase in the total homicide rate.” The quantitative values help readers understand the exact degree of which guns are dangerous, but fail in connecting readers on an emotional level. Blood Drive, however, portrays the message more effectively by using the inverse extreme, instead of blatantly arguing against guns
The Oxyglobin and Hemopure substitutes developed by Biopure have an advantage over blood transfusions in many areas including blood type matching, universality in terms of donating, such as O+ blood recipients. The blood substitutes also had a much longer storage life of 2 years as opposed to the 6-week storage life of transfused blood. Furthermore, with the rise of diseases such as AIDS and increasing public concern about the same, blood substitutes also helped mitigate that risk. Baxter International and Northfield Laboratories-products sourced their blood substitutes from human blood whereas, Biopure sourced it from animal blood, cattle in particular. This put them in a better position than their competitors. Also Biopure’s Hemopure and Oxyglobin did not require refrigeration unlike its competitor’s products.
The Blood Drive is a satirical story addressing the dangers of laissez faire gun laws and treating children as having the same capacities as adults. When you give a child a gun you’re saying you recognize them as having the same capacity for reasoning as adults. When you remove the responsibility from adults you allow them to regress to childish behavior. Blood Drive shows that a society that lacks discipline and order is doomed to chaos and tragedy.
Meeting the demand for blood in the United States is no small feat. Every two seconds someone is in need of blood in the United States and 36,000 units of red blood cell each day. Furthermore, there are many reasons that a person may not be able to donate blood, resulting in only 38% of the population being eligible to donate blood. (“Blood Facts”) Therefore, a policy that allows more people to donate blood is intuitive.
In order for the Canadian Blood Services to meet the demand of blood needed to serve patients, the CBS must increase the amount of donors that give blood. The demand for blood continues to rise. Finding ways to attract people to donate blood can be problematic so that finding incentives for people to donate can be a difficult task.
Exclusion criteria for the study included: Patient refusal to consent (absolute), infection in the patients back near the proposed site of the injection, coagulation disorder :-( defined as PT: > 18 sec, PTT: >40 sec, I.N.R: > 1.5, clotting time: >8 min, platelet disorder: platelet count: < 100.000, bleeding time: >4 min, HELLP Syndrome: - (defined as Hemolysis, Elevated Liver enzymes, Low Platelet count), receiving any anticoagulant drugs, preexisting neurological disease or psychic patients, history of cardiac and respiratory system failure, known allergy to local anesthetics drugs, coexisting renal disease and eclamptic patients.
The Australian Red Cross Blood Service (ARCBS) has identified a long-standing issue of poor repeat blood donation from young donors, in particular males. While this group of the population has a high number of new donors, it has been found they are also the least loyal, which poses a problem for both current and future blood stocks. As a marketing consultancy firm, we have been commissioned to analyse the issues surrounding blood donation in Australia, and to devise three cost-effective marketing strategies aimed at increasing repeat donation from this demographic.
The market of human blood transfusions is broken down into different uses: Elective Surgery, Emergency Surgery and Trauma. However, Hemopure seems to be suitable only for trauma cases due to its characteristics and, again, high price. To understand the reason, it is important to notice that, actually, only 10% of the 500,000 trauma victims receives RBCs “in the field” or at the site of accident, and the remaining 95% of these people does not receive transfusions until they arrive at the hospital. This delay was often cited as a major factor to the 20,000 trauma deaths. Therefore, since the expected market share for Biopure is 25% and assuming that the total blood transfusions remain stable, the potential market size for Hemopure is approximately $350,000,000. This size is based on an average price of $700 multiplied by 2,000,000 units (around 4 blood units are needed for each Trauma case).
Blood chemistry or blood test is identifying the different levels of chemical ingredients found in the blood. The analysis of these substances provides clues to a patient’s condition and the functioning of the major body systems such as, blood sugar levels, liver functions, essential nutrients etc. This helps doctors in diagnosing the patient’s conditions much easier and quicker.