Introduction: Cancer, which is also known as malignant tumor, is a big threat to the humans. As the development of medical science and technology, many terrible diseases in the history have been eradicated or controlled such as smallpox, cholera, and phthisis. But why cancer is still threatening human, making people suffering so much? The reason is that people still don’t know the mechanism of cell canceration.
In the view of biological evolution, the history of cancer is even longer than that of the human being, because before the appearance of human, there have been other animals and plants living in this planet, and the malignant tumor may just appear on any kinds of creatures. But the real beginning of cancer research only start
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As for the theory about the origin of canceration, there are 2 main different opinions. One side insists that the canceration is a result of the change of genes. In another word, it is because the gene mutation under the influence of the many factors that cause the result. While another side think that the gene will not change in this process, and the real reason is that the process of the control and expression of genes comes about mistakes, resulting in abnormal cell differentiation and even abnormal membrane features and defects of immune system.
The former is called the gene theories, and the latter is known as epigenetic theory. Later, some scholars combined both of these two theories to explain the mechanism of cancer. And they can be called comprehensive mechanism. And only after the discovery of oncogenes in human tumors, there appears to be some breakthrough in the research of the mechanism of carcinogenesis. We will discuss these different hypotheses of mechanism of carcinogenesis process separately next.
1. Genetic mechanism The theory of mutant of somatic cells is said to be the main representative of this side. As early as 1914, Boveri, a German scholar has illuminated in his book "the origin of cancer" that ‘Originally from a single cell tumors, chromosomal abnormalities must be composed of farmers and endowed with all the characteristics of tumor cells. In 1923, Bauer systematically raised the theory of tumor
Cancer is a multi-step disease that can originate from any cell type, but the majority of human cancers are epithelia-derived carcinomas (Yang and Weinberg 2008). The first step in
Our genes regulate cell growth and cancer occurs due to abnormal changes in these genes. Genes are in each cell's nucleus and control the cells growth in relation to our genetic make up. The cells grow and replace themselves in a natural
Paleopathological findings indicate the presence of tumors through animals well before prehistoric times. Steven Hajdu explains that written descriptions of cancer date back to the Egypt, Byzantine and other Indo-European civilizations where medicine men attempted to cure it using herbal remedies and did not hesitate to use concoctions of iron, copper, sulfur and mercury (1), elements known for its toxic nature. Failing to treat the diseases because of both the lack of knowledge of the human anatomy and DNA or proper equipment, they would claim that the wrath of God had struck upon the ill patient. Medicine Men of this time also did not strive to further study cancer since mortality rates were low due to lack of food, clean water and constant
It is stated in the article that humans and fruit flies share similar genes, thus the scientists conducted the experiment on fruit flies, therefore, it is of high importance to implement this new data to help treat and prevent human cancers. If research continues to prosper and scientists like Tamori, Deng, and Suzuki extend their experiment from fruit flies to humans, there is a possibility that they may find factors that cause the development of tumors in humans. Tamori, Deng, and Suzuki were able to generate a thesis regarding the part epithelial tissues play in the development of tumors in fruit flies and then transcribe that information and correlate it to tumors in
Cancer occurs when cells in the human body create irregularities and start to duplicate at anomalous quick rates. The outcome is the development of tumors in or on the surface of the body and organs. Tumors might be generous (not destructive) or threatening (harmful). Since ordinary cell improvement and duplication is a moderate procedure which is well controlled, it is evident when cells duplicate so rapidly.
Throughout life, many individuals experience difficulties due to growing up in everyday life. While going in depth of the human life, it is discovered that there are many diseases and disorders that affect humans’ everyday functions. A very popular disease that has traumatically affected the human body is cancer. Cancer is a disease that spreads throughout your body in many ways. The purpose of cancer is to attach to a blood cell in your body and cause a plague within itself, causing the body to initially shut down and die. This disease contains many forms and have many causes to it. However its main goal is to destroy the human body.
“The Emperor of All Maladies” captured the whole essence of cancer. This book gave a very good narrative of the historical record of cancer, the scientists and important public figures who contributed to the fight against a disease that has so much caused despair, pain, disfiguring of the body and worst of all, death. Cancer is seen as the abnormal growth of cells. A normal cell becomes cancerous when there is a defect in the regulation of its growth. Cancerous cells also tend to be elusive and resistant to treatments. Numerous attempts have been channeled into demystifying the nature of cancer. Some of these attempts proved abortive while a few served as a harbinger of hope. Cancer have proved to be part of our genetic makeup, hence, total eradication of it remains a future accomplishment.
Cancer is one of the leading causes of death worldwide as it can develop in almost any organ or tissue. Significant advances in understanding the cellular basis of cancer and the underlying biological mechanisms of tumour has been vastly improved in the recent years (Jiang et al. 1994). Cancer is a genetic disease which requires a series of mutation during mitosis to develop, its characteristics can be associated with their ability to grow and divide abnormal cells uncontrollable while in the mean time invade and cause nearby blood vessels to serve its need. Even though many people are affected by cancer today, the abilities which cancer cells have make it hard to find a single effective treatment for cancer. The focus of research now lies
There are many ways that you can get cancer. You can get cancer from smoking, sunlight, your diet, mold, viruses, and inheritance. Out of those factors, the most common cause of cancer today is smoking. All cancers are genetic because they are caused by the mutations that happen to the gene. Some common cancers that are
Since the DNA is passed down from parent to offspring, the risk of developing certain diseases, including cancer is passed down as well; the DNA is divided down into genes. Cancer cell growth is a result of abnormal cell growth after there has been an error in the cells DNA, thus causing a mutation. Cancers can be caused by DNA mutations that activate oncogenes or inactivate tumor suppressor genes. In many cases, genetic testing can be used to see if someone has one of these mutations. Most bone cancers are not caused by inherited DNA mutations. They are the result of mutations acquired during the person’s lifetime. These mutations may result from exposure to radiation or cancer-causing chemicals, but most often they occur for no apparent reason. Scientists are making progress in understanding this process but there are still some points that are not completely understood. As their knowledge increases, they hope to develop ways to better prevent and treat bone cancers (Cancer.org).
Cancer is characterized by unregulated/uncontrolled growth and spread of abnormal cells. The etiological factors of Cancer include both external factors (tobacco, infectious organisms, chemicals, and radiation) and inherent factors (inherited mutations, hormones, immune conditions, and mutations that occur from metabolism). The etiological factors may act together or in sequence to trigger the development of cancer. It may take several years for the manifestation of the disease to be obvious after the initial trigger.
When mutations in the genes accumulate over time in multiple genes that are in control of cell proliferation the cells become cancerous ("Cell Division and Cancer"). After this occurs the cells begin to grow and divide rapidly causing lumps called tumors to form ("How cancer starts"). The gene mutations that can cause breast cancer are many. Some common causes include mutations in proto-oncogenes which are genes that assist the cell in growing normally. When they mutate or are too abundant they can activate randomly causing cells to grow and multiply out of control. Another cause is inherited gene changes. These inherited DNA mutations cause increased risk for developing certain types of cancer such as breast cancer. For example those
One gene that cause an increased risk for cancer is the p53 gene. This gene functions by controlling the cell cycle. It causes and increased risk for cancer by being mutated to many times and is usually the cause of over 50% of all human cancers. Another cell that causes an increased risk for cancer is the BRCA1 gene. This gene functions to stop tumor formations and growths. If the gene has a mutation then a tumor will begin. This is one of the genes that will cause breast cancer. The two types of tumors are benign and malignant. Benign tumors remain at the original site of formation and can be removed by surgery or radiation. Malignant tumors send out a signal to start a blood vessel line at the tumor to spread the cancerous cells around the
- There are different kinds of Cancers that can be caused by many different factors.
Cancer is a genetic disease caused by certain changes to genes that control the way our cells function, especially how they grow and divide. Genes carry the instructions to make proteins, which do much of the work in our cells. Certain gene changes can cause cells to evade normal growth controls and become cancer. Genetic changes that promote cancer can be inherited from our parents if the changes are present in germ cells, which are the reproductive cells of the body (eggs and sperm). Such changes, called germline changes, are found in every cell of the offspring. In general, cancer cells have more genetic changes than normal cells. But each person’s cancer has a unique combination of genetic alterations.