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Autoregulation Research Paper

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It has been proved that defective autoregulation has relationship with pathologies like diabetes and glaucoma. Autoregulation in the eye is defined as local vascular constriction or dilation causing vascular resistance to reciprocally increase or decrease, so therefore maintaining a constant nutrient supply in response to ocular perfusion pressure changes [Harris1998]. In the situation with increased IOP, varying blood pressure and changes in normal blood flow figure out a result ocular perfusion pressure decreased and local tissue metabolic pressure increased. Deficiency of stable blood flow autoregulation may lead to ischemic damage of the optic nerve and retinal ganglion cells, which likely contributes to further destruction in vascular regulation. These disadvantages of events might be occur retinal ganglion cell death and structural changes of the optic nerve head …show more content…

These characteristics of the glaucoma patient can progress to blindness. Regularly, glaucoma and its treatment have been closely connected with intraocular pressure. In normal tension glaucoma, damage to the optic nerve occurs without any increase in intraocular pressure. Normal tension glaucoma most often occurs in the elderly and can lead to loss of sight and significant disability. Numerous studies indicate that glaucoma patients have altered retinal circulation. Extensive morphological studies describe endothelial proliferations in the retinal vessels of glaucoma patients. [Charlson2011] In study [Evans1999] Evans et al. assert that glaucoma patients demonstrate faulty autoregulation in the retina during posture change: their CRA response to posture variation shows no change. The CRA directly feeds and is the only source of blood supply for the retinal arteries. These distal vessels nourish the retinal ganglion cells and the confluence of unmyelinated nerve fibers anterior to the lamina

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