An Evidence Vitro For The Influence Of Bisphenol A On Uterine

Religion played a big role in shaping the values, attitudes, and conduct of the Spanish during the Age of Discovery and Conquest (1492-1579). The colonial church provided control and a standard of conduct and living for the new world. In fact, the colonial church had even more power in Spanish America then it did in Spain. Why this is important though, is because it limited the possibility of rebellion and opposition. As long as the church was in place, there was Spanish order, and as long as there was Spanish order, the colonization process could continue to run smoothly and prosper.

Reinberg, S. (2013, July 31). Plastics Chemical BPA May Harm Human Fertility. Retrieved April 11, 2017, from http://www.webmd.com/baby/news/20130731/plastics-chemical-bpa-may-harm-human-fertility-study#1

Janet presented with uterine fibroids, otherwise referred to as leiomyomas. These tumours are composed of muscular tissue and are found within the uterus. Research has found no direct cause of leiomyomas however, it is known that the development and growth are dependent on ovarian hormones (Brown, Edwards, Seaton, & Buckley, 2015). Levels of these hormones vary throughout a woman’s life depending on her age and genetic predisposition; risk of developing leiomyomas is lowest in prepubescent and post-menopausal women and highest during pregnancy (Tinelli & Malvasi, 2014). An increase in hormone production causes these fibroids to grow rapidly.

Bisphenol A or better known as BPA is a synthetic compound that is used to make several different items. BPA was founded in the 1890’s by a Russian chemist. It was initially tested in the 1930’s as a substitute for estrogen, but upon testing found it less effective than estradiol. In 1953 polycarbonate resin was invented. This was a strong plastic material which was initially used for wiring, fuse boxes, distributors and glazing. During that same period it was found useful in making plastic bottles and lining of metal cans. It wasn’t approved by the FDA until the 1960’s for food packaging. It is also used in recycled paper used to print out receipts from stores (Caliendo, 2012)

Another factor that contributes to the development of breast cancer is actually the hormone estrogen. This seems unusual because estrogen is a hormone that is essential to the bodies of women in various ways. Estrogen is necessary for normal growth and development of breasts and reproductive organs, as well as for the maintenance of a healthy heart and bones. However, lifetime estrogen exposure may increase a woman’s risk of developing breast cancer. It does not actually produce the mutation in the DNA, nevertheless Estrogen stimulates the proliferation of breast cells that already contain a mutation. These mutated cells will continue to reproduce and have an increased chance of becoming cancerous.

Uterine leiomyoma also known as uterine fibroids are non-cancerous tumors in women during childbearing age. The tumors come from smooth muscle cells of the myometrium within the uterus that changes in size and cellular properties during the reproductive years of a woman. The change in size and cellular property with hypertrophy of the smooth muscle cells normally happen during pregnancy and also occur with uterine fibroids. The development of the tumors is dependent upon estrogen and progesterone and interaction with growth factors, cytokines and extracellular matrix components (Taylor, Holthouser,

Fibroids are becoming more and more common in women in the United States. It is estimated that 171 million women in the U.S. were affected by this condition in 2013(6). About 20% to 80% of women develop fibroids by age 50 (6). As many as three out of four women may have uterine fibroids in her lifetime (4). Fibroids, also known as uterine leiomyoma, are benign tumors that can be found in women of childbearing age due to its dependence on estrogen and progesterone (7). They are made of muscle cells and other tissues that can grow around or in the uterus or womb. With fibroids, a single cell divides repeatedly, eventually creating a firm, rubbery mass distinct from nearby tissue (2). Some fibroids even go through growth spurts where they grow and shrink on their by itself. There are women with fibroids who have no symptoms at all. If they do, it may consist of heavy or painful periods, frequent

Chemicals are also suspected to cause breast cancer. Xenoestrogens are chemicals with estrogen-like effects, they are found in pesticides and other common industrial products. Other estrogen-like chemicals that have a stronger association with breast cancer include dieldrin and beta-hexachloraocyclohexane. Although these chemicals are very weak estrogens, one study showed that exposure to single weak-estrogen compounds isn’t a big risk but a combination of two or more chemicals result in extremely high estrogenic

In the year 2011 there were many reports in the media regarding bisphenol A (BPA). BPA is a hormone-disrupting chemical linked to adverse health effects like cancer, infertility, diabetes, obesity and ADHD (Newbold, 2009)

Uterine Fibroids are non-cancerous growths that develops in the myometrium layer of the uterus. A single cell divides repeatedly, eventually creating a firm, rubbery mass distinct from nearby tissue (EA, 2013). There are different types of growth patterns to uterine fibroids. Sometimes they are small and in some cases they are extremely large. Woman between the ages of 30-and 40 years old are more at risk of developing uterine fibroids. They develop mostly in the child bearing years of a woman’s life. African American women have a greater risk of developing uterine fibroids at a younger age than any other race. Uterine fibroids are also called leiomyomas or myomas. Uterine Fibroids can develop on the inside or outside of the uterus.

Ovarian cancer is cancer that begins in the ovaries. Ovaries are reproductive glands establish only in women. The ovaries produce eggs (ova) for reproduction. The eggs journey during the fallopian tubes into the uterus where the fertilized egg embeds and establish into a fetus. The ovaries are also the major cause of the female hormones estrogen and progesterone. One ovary is situated on each side of the uterus in the pelvis. Many types of tumors can generate rising in the ovaries. The majority of these are benign (noncancerous) and never multiply outside the ovary. Benign tumors can be treated effectively by removing either the ovary or the part of the ovary that contains the tumor. Ovarian tumors that are not benign or malignant (cancerous)

Fibroid, a benign tumor that affects the uterus can be controlled with natural cures, and there may not be need for surgery or hysterectomy. Fibroids are non-cancerous growths of tissue that grow in the wall of the uterus. They vary in number and size, and can be small as peanut or big as a melon.

During recent years, numerous newspaper and magazine articles have suggested that humans may be at risk because small amounts of well known environmental contaminants, such as dioxin, PCBs and DDT, can affect hormone levels. Hormones are produced by the endocrine system as regulators of biological function in target organs. Because hormones play a critical role in early development, toxicological effects on the endocrine system often have an impact on the reproductive system. The term endocrine disruptor is used to describe chemicals that can mimic hormones and may either enhance or counteract their effects. It has been suggested that these hormone changes can, in turn, lead to a variety of health problems

The plastic monomer bisphenol-A, identified by mass spectrometry, was found as a contaminant not only in the liquid of the preserved vegetables but also in water autoclaved in the cans. The amount of bisphenol-A in the extracts accounted for all the hormonal activity measured. Although the presence of other xenoestrogens cannot be ruled out, it is apparent that all estrogenic activity in these cans was due to bisphenol-A leached from the lacquer coating. (1).

In 2002 a study conducted found that parabens mimicked the hormone estrogen by binding to estrogen receptors on cells. The study also discovered that parabens increase the expression of genes usually regulated by estradiol, the genes that cause human breast cancer cells to grow and