Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic meaning, “no muscle nourishment” in Greek, lateral meaning where the neurons are in the spinal cord, and sclerosis meaning “scarring.” ALS, often known as “Lou Gehrig’s Disease,” named after the New York Yankee who first brought awareness to the disease in the late 1930’s, is a neurodegenerative disease, which affects the neurons in the brain. The nerve cells in the brain and spinal cord that are responsible for sending and receiving motor signals progressively die off, causing the deterioration of simple motor skills in patients with ALS, such as walking, talking, and eventually speaking and breathing, however thinking is not affected by ALS. Early symptoms cause the person to slowly lose mobility of limbs, but in a matter of a few years, the person loses the mobility of most of their body and will eventually lose the ability to eat and breath, which will ultimately cause death. ALS deteriorates the patient's body, however does not affect the patient's state of mind or sanity while the rest of the body shuts down. People usually get ALS between the ages of 40 and 70. However, there is a growing trend where athletes are getting ALS in their thirties. ALS can be contributed to genetic predisposition, which means that the gene that is responsible for ALS is already in the person’s DNA. In recent studies, however, it was observed that individuals who have had suffered multiple concussions or any other head trauma are

The article titled “The Voices of A.L.S. by Tara Parker-Pope has given me a better insight into A.L.S. In fact, it has made me more aware of it. Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease, affects parts of the nervous system that control voluntary muscle movement. Motor neurons, among the largest of all nerve cells, reach from the brain to the spinal cord and from the spinal cord to muscles throughout the body. When these motor neurons die, the brain can no longer start and control muscle movement. At this time there is no cure for the disease; however, over the past few decades, we have made amazing strides in our understanding of the brain, the nervous system, and genetics. Discoveries in each of these areas bring

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a terminal disease that degenerates the nerves in the brain and spinal cord. Motor neurons run from the brain, through the spinal cord, and into the muscles of person; this is what allows a person to have control over voluntary movement. When an individual is diagnosed with ALS, their motor neurons begin to degenerate, thus eradicating their ability to walk, eat, and eventually breathe.

Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a neurological disorder that involves the degeneration of motor neurons. Commonly, ALS is referred to as “Lou Grieg’s disease” after the New York Yankee Hall-of-Famer, who was diagnosed with the disease in 1939 (mayo Clinic, 2010). According to the national institute of neurological disorders, ALS is a rapidly developing, consistently progressive, invariably fatal neurological disease that’s attacking the nerve cells needed for controlling voluntary muscles, or movement.” (NINDS, 2010). The muscles go through atrophy, which means the muscles gradually weaken and wasting away. Furthermore, ALS affects the neuromuscular system, which “enables our bodies to move

Amyotrophic Lateral Sclerosis (ALS) is a terminal disease, also known as Motor Neurons Disease, Charchot Disease and Lou Gehrig disease. ALS destroys the Central Nervous System (CNS) and causes damage to the upper and lower motor neurons in the brain. Signs and symptoms are characterized as: muscles weakness, muscle atrophy, twitching and reduced muscle reflexes. Eventually the patient will become paralyzed and rely on a tracheostomy and ventilator for breathing (ALS Association [ALSA], 2010).

There are 20,000 new cases of ALS diagnosed each year in the United States. This yields an incidence of 3 per 100,000 (Brown, 2006). There is no known cause for ALS in 95% of patients; however, 5% have an identifiable genetic mutation (Elman, 2016). The disease can present in individuals less than 30 years of age, but peaks between 40 and 60 years of age. Before the age of 65, more diagnoses are made in men; after the age of 65, gender incidence is equal. There is no clear-cut ethnic or racial predisposition in ALS (Ricks, 2016). The lifespan is approximately 3-4 years after diagnosis. However, in 10 % of

ALS (Amyotrophic Lateral Sclerosis) or Lou Gehrig’s Disease is a classified as a degenerative neurological disorder that inhibits motor neurons in the spinal cord and brain to function properly. This disease eventually results in paralysis and imminent death over a period of time. ALS patients have anywhere from a few months, to a couple years to live after diagnosis since their nervous systems are slowly destroyed, rendering the body useless, and sustaining life impossible.

It's a brave question because the answers are not very pleasant." When an individual is diagnosed with ALS, they begin a totally new way of life. Surprising, in many cases it can often be difficult to diagnose someone with Amyotrophic Lateral Sclerosis. However, with a history of their problems and a few other tools, it is possible. One of the most common ways to diagnose someone with Amyotrophic Lateral Sclerosis is by looking at their complications. Some of the most common early signs of ALS are a patient's legs may seem to be heavier than normal or

Moglia, P. P., & Margolis, D. D. (2017). Amyotrophic lateral sclerosis. Magill’S Medical Guide (Online Edition)

The manifestations of ALS are caused by the location of motor neuron death. When upper motor neurons die, the symptoms include problems controlling fine movements, spasms, dysphagia, dysphonia and dysarthria (Porth & Matfin, 2009). “Manifestations of lower motor neuron destruction include fasciculations, weakness, muscle atrophy, and hyporeflexia” (Porth & Matfin, 2009, p. 1284). Patients with early signs of ALS usually complain of feeling weak on one side, which is due to the slowing of electrical impulses to that group of muscles (Ignatavicius & Workman, 2010). Since the impulses are slowed, they are not receiving adequate electrical stimulation to move and the person feels weak. As the disease progresses, all the motor neurons die and are not regenerated so, the patient is left paralyzed, losing the ability to speak, swallow and breathe (Ignatavicius & Workman, 2010).

Amyotrophic Lateral Sclerosis (ALS), also known as Lou-Gehrig’s disease, was first described by Charcot in 1874. “Amyotrophic” pertains to the lower motor neuron signs of muscle weakness, atrophy, and fasciculations. “Lateral sclerosis” refers to the gliosis of the lateral column of the spinal cord found in autopsy specimens following degeneration of the corticospinal tracts. This is clinically manifested as upper motor signs like hyperreflexia, clonus, extensor toe signs, and Hoffmann

ALS is named for its underlying pathophysiology, which is “amyotrophy” referring to the atrophy of muscles fibers, which denervated as their corresponding anterior horn cells degenerate. “Lateral sclerosis” refers to the changes seen in lateral columns of the spinal cord as upper motor neuron axons in these areas degenerate and are replaced by fibrous astrocytes. ALS affects motor neurons at two or more levels of the motor neuron network supplying multiple regions of the body and as a consequence, the communication between the neurons and muscle is lost, promoting progressive muscle weakening. That is, ALS affects lower motor neurons that reside in the anterior horn of the spinal cord and in the brain stem, corticospinal upper motor neuron

In order to recognize ALS, there are various signs and symptoms to look out for. The classic presentation of ALS is insidious, progressive, asymptomatic muscular weakness and atrophy along with neurologic signs, particularly hyper-reflexia. The precise signs and symptoms of ALS depend on the area of the nervous system that is damaged. Patients with upper limb onset may first notice difficulty in actions such as, buttoning cloths, picking up small objects or turning keys. Those with lower limb onset may complain of stumbling, tripping, foot drop, or awkward when walking or running. Speech problems, such as slurring, hoarseness or decreased volume, are most common presentations in the bulbar form of ALS. Subsequently, spreading paralysis of the

ALS, commonly known as Lou Gehrig’s Disease, is a progressive neurodegenerative disease that affects the motor neurons in the primary motor cortex, corticospinal tracts, brainstem, and spinal cord (Wijesekra & Leigh, 2009). As a result of the

Have you ever heard of ALS, better known as Lou Gehrig’s disease? For many people, ALS is a disorder that they may not know much about. I never heard of it either until my father was diagnosed with this disease in 2006. Because there is no known cure, it is important to detect this disease early, so that proper treatments and preparation can be done before it’s too late.