Indications for use – “a reason to prescribe a medication or treatment, also known as drug indication” (Mosby’s, pg 916, 2017). High-risk neuroblastoma is an indication of use for Unituxin (dinutuximab) (FDA, 2015). Desired effects – “the ability of a drug to achieve the desired effect, also known as efficacy” (Mosby’s, pg 593, 2017). Unituxin in combination with interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF), and 13-cis-retionic acid (RA) showed that 73 percent of the participants who received this combination were alive compared to 58 percent of those receiving the oral retinoid drug, isotretinoin (RA) (FDA, 2015). Side Effects – “any reaction to or consequence of a medication or therapy” (Mosby’s, pg …show more content…
Signs or symptoms could include lumps in the abdomen, bone pain, bulging eyes, dark circles around the eyes, swollen stomach, trouble breathing, weakness or paralysis. Once neuroblastoma has been diagnosed, it has usually metastasized to the lymph nodes, bones, bone marrow, and liver (NIH, n.d.). The therapeutic classification of Unituxin (dinutuximab) is a monoclonal antibody, which is a type of immunotherapy drug. Unituxin helps the body’s immune system find and destroy cancer cells. It is used along with other treatments, which include chemotherapy, surgery, and radiation for children who have responded to previous treatment (Simon, 2015). The indications of use for Unituxin are used in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2) and 13-cis-retinoic acid (RA), for the treatment of children with high-risk neuroblastoma who achieve at least a partial response to prior first-line multi-agent, multimodality therapy (United (c), 2017). The available form of Unituxin is 17.5 mg/mL (3.5 mg/mL) in a single-use vial. Children and Adolescents - 17.5 mg/m2/dose as an IV infusion over 10 to 20 hours on scheduled days for 5 cycles in combination with isotretinoin, sargramostim, and aldesleukin. On cycles 1, 3, and 5: give sargramostim 250 mcg/m2/day subcutaneously (or as an IV infusion over 2 hours) on days 1 to 14; dinutuximab on days 4, 5, 6, and 7; and isotretinoin 160 mg/m2/day PO in 2 divided doses rounded
It has broad variety of anti-tumor activity and forms the backbone of combination chemotherapy regimes presently
Any adverse event for which the specificity or severity is not consistent with the protocol-related documents, including the applicable investigator brochure, IRB approved consent form, Investigational New Drug (IND) or Investigational
Patients are intrigued by the idea that a medication will actually fight for them and be a powerful ally, in comparison to their current treatment that does “just enough” to get them by. They can
In my opinion, the medication side effects are the most important risk to be considered. The reason for my opinion, is the direct relation between the medication side effects and the patients’ safety.
These malignant solid tumors like other dangerous cancers require treatments and Taxol known by the generic name Paclitaxel is used. Taxol (Paclitaxel) is a
Media and how it makes people behave The media is all around us. One form its brought to us is by magazines. Magazines are printed out daily bringing people the latest stories of celebrities, things going on around the world and much more. From the first glance it might not seem so bad but if you dig deeper into what the media is doing then you might just be surprised.
There are signs that could be the result of a brain tumor. Symptoms include seizures, severe or persistent headaches, increasing irritability, changes in personalities, unusual fatigue or sleeplessness, nausea and vomiting, difficulties with hearing, speech, taste, smell, or bladder. Seen in [Siegel, Mary-Ellen. The Cancer Patient's Handbook: Everything You Need to Know about Today's Care and Treatment. New York: Walker, 1986. 127-28. Print. ] Often these symptoms lead to something less extreme, but you should be more concerned with seizures. There are treatments for neurological cancer that include surgery, radiotherapy and chemo therapy often all of these. Diagnosis is found through history of patients and reflexes. They also include a spinal tap, skull X rays, CAT scans, EEG,
patient abuses the drug there is a high risk of addiction. Many patients need 4 milligrams of the
Romidepsin, which is also known as Istodax® as its trade name, is approved by the Food and Drug Administration (FDA) on November 5, 2009, as an anticancer chemotherapy drug used for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior therapy and for the treatment of peripheral T-cell lymphoma (PTCL) in patients who have received at least one prior systemic therapy. Romidepsin is a histone deacetylase inhibitor (HDACi), which exhibits high level of HDAC inhibitory activity for class I histone deacetylase (HDAC).
The drug is called temozolomide (Temodar) and is used to treat anaplastic astrocytoma which is a form glioma that is considered to be high on the grading scale. Usually, a high-grade glioma would be a Grade III tumor that reoccurs after other therapies (Johnson et al. 2005). A few years later, in 2005, temozolomide earned full approval for high-grade gliomas. The data from the research showed that adding the temozolomide to the initial radiation therapy, it increases survival, of what would usually be two years by as much as 50 percent. In the same year, researchers discovered that patients with tumors could benefit from temozolomide (Temodar) therapy when carrying a specific alteration in a gene. This alteration is called MGMT. The MGMT gene plays a part in repairing DNA damage that occurs within cancer cells. This also includes damage that has been caused by chemotherapy. Researchers are continuing to explore ways of better identifying which patients are the most likely to respond positively to this chemotherapy (Cohen et al.
In the clinical setting, it would be advantageous to facilitate the use of a self-administered neurotoxicity portion of the FACT/GOG questionnaire. The at risk chemotherapy patient could complete it upon arrival to the infusion center. This could be followed by performing the abbreviated TNSc, which would consist of a
If you're the type of traveler who revels on the enjoyment offered by outdoor activities, then you must put Ushuaia on your bucket list for dream travels. The very location of this suburban town makes it cognitive and perfect for several things that will bring about the rush within you such as hiking, skiing, sailing, kayaking and scuba diving, along with other water and land activities. Map out your options through dozens of restaurants to ease the pain of all-day walking, chill out on cafeterias and spark some conversations with Ushuaia's hospitable locals. Known to be the 'southernmost city' of the world, Ushuaia would craft a vacation that you've always wanted---the serenity of watching Antarctica-bound
Brain cancer is usually accompanied at first by headaches and seizures. Later symptoms could include nausea, vomiting, fever, change in pulse, and trouble breathing. Other mental changes may also occur such as difficulty in communication. Symptoms greatly depend on the location of the tumor. For example, if the tumor were located on the part of the brain controlling vision, then vision would be affected.
I feel that everyone has an idea of what the opportunity cost of war is. One would most certainly think that one opportunity cost is the lives that those who lost their lives in a war could have lived as well as the amount of money spent on such war that could have been spent on something more beneficiary for our society. Dr. Weigl’s interview did, however, allow me to think of such opportunity costs more deeply.
There are many different type of cancers, there are also many different types of treatments. One of the most known types of treatments would be chemotherapy. Chemotherapy can be used for a wide range of different types of cancers and diseases, and each of the different types of cancers or diseases require a different group, and sometimes order, of chemicals to properly treat the cancer or disease. These chemicals include: Alkylating agents, Antimetabolites, Anthracyclines, Topoisomerase inhibitors, mitotic inhibitors, corticosteroids, and more. Each of these drugs previously listed have its own cancer type(s) or disease(s) that it can assist in treating. Some of these cancers include: Leukemia, Lymphoma, Hodgkin disease, multiple