Abstract
Alzheimer’s disease is a neurodegenerative disorder that represents the most common type of dementia in the elderly. The disease is characterised by progressive dementia that inevitably leads to incapacitation and death. The most common and distinctive hallmark lesions present within the disease brain are the senile plaques and neurofibrillary tangles. The amyloid plaques is a major component of the disease, and is constituted mainly by the neurotoxic amyloid-β42, which is a product of the amyloid precursor protein. Mutations on the amyloid precursor protein alters the proteolytic processing, leading to overproduction and accumulation of the neurotoxic amyloid-β42, generating a progressive deposition of protein fragments in amyloid
In the year of 1906 in Germany, a researcher named Alois Alzheimer discovered a disease that was at first overlooked by fellow scientists but years later became a rather fascinating finding - Alzheimer’s disease. Alzheimer was studying a fifty-one-year old woman that was admitted into Community Psychiatric Hospital in Frankfurt, Germany with some strange mental issues such as confusion, memory loss, and others by her husband who could not figure out what had happened to cause these things. She stayed at that mental hospital until her death five years after her admission. After she passed Alzheimer went ahead and performed an autopsy to her body.
Alzheimer's disease is a broadminded disease that corrodes memory and other vital mental roles. It is the most common factor that leads to dementia which is a brain disorder that results in loss of academic and social skills. These changes can effect anyone severely enough to affect with everyday life. While having Alzheimer's disease, the brain cells corrupt and die, which causes a stable decline in memory and mental function. Currently Alzheimer's disease medications and management tactics may only momentarily progress symptoms. This sometimes helps people with Alzheimer's disease exploit purpose and preserve independence. But since there is no cure for Alzheimer's disease, it is important to seek helpful facilities as early as possible.
Therapy- (most therapy in later stages is aimed at physical health, mental health therapy is recommended for family members & loved ones)
--- Alzheimer’s disease is without a doubt a fatal disease, according to Dr.Maurizio Grimaldi he says “Alzheimer's disease (AD) is very complex and always fatal. It manifests initially with marked memory failure, but as it progresses, it also has an effect on higher brain functions. In the later stages of the disease, balance and coordination as well as autonomic functions like heart rate, breathing, digestion and sleep cycles are severely affected.
Alzheimer disorder is an major nervous condition that present in irreparable loss of neuron in the cortex and hippocampus of the brain. The recurrence of the disease is 7% of people above 65 years old and 40% of individual above 80 years old. Patients commonly have issues in decision making, remembrance, and judgment. Pathological lineaments are specified as loss of neuron, extracellular senile plaques include peptide β-amyloid. Diagnosis is established on neurological feedback to rule out other reasons by using autopsy. Dopamine as neurotransmitter has an important part in etiology of Alzheimer disease and it is reduced in this disease.[3]
Imagine if every individual on Earth traveled and attempted to live on a different planet. In reality, lifeforms on Earth cannot sustain life on another planet, it is impossible. The reason being is that lifeforms on Earth require specific (environmental factors) climate, nutrition, and atmospheric exposure. Therefore, an apocalypse could happen through neurodegenerative disorders, excessive climate change (rainfall), and depletion of the ozone layer caused by global warming.
Alzheimer's Disease (AD) is the most prevalent form of dementia, affecting 10% of the population over the age 65 and 50% of the population over 85 (Zhang et al,. 2011). This neurodegenerative disease causes mental and cognitive deficits such as severe memory loss and behavioural changes (Hubin et al,. 2015).
Severe decline is the sixth stage of Alzheimer’s, at this stage the person needs constant supervision, and they require professional care (“What Are The 7 Symptoms of Alzheimer's Disease?”). During this stage, the signs of Alzheimer's have become worse and more evident. Family and friends can easily notice the changes in the person’s behavior. “During stage 6, there are five identifiable characteristics that develop over the course of 2 1/2 years” (Ellis and Higuera). One of the five characteristics that the person will develop is dressing properly. The person with Alzheimer's will have trouble dressing correctly and he of she will need help dressing. The second out of the five characteristics is hygiene. The person's hygiene will start to
Alzheimer's disease is an incurable disease of the nervous system. Most often occurs in older people and is characterized by the destruction of brain cells. In brain tissue formation of neurofibrillary tangles and neuritic plaques. This degenerative disease is the most common form of senile dementia.
Alzheimer’s Disease is a horrible disease that is a form of dementia also known as senile dementia. When Alzheimer's is found in someone, it means that they will have memory loss and certain daily functions will be harder to do, because of the lack of memory. It accounts for 60-80% of dementia diagnoses.
Alzheimer’s disease (AD) affects everyone involved: the victim and his/her’s loved ones. First of all, caregivers are often overlooked, and never realized for what sacrifices they give up to care for their loved one. Secondly, the financial burden of caring for someone with Alzheimer’s is a big job that can hurt the opportunities that needed more time to get a better degree. Thirdly, although the victim of Alzheimer’s disease is the ill one, usually, they aren’t the only one suffering from this terrible disease. People must know that the caregivers are fighting just as much as the victim of the disease.
One of the most common forms of dementia, Alzheimer’s disease is a brain disorder which impacts activities of daily living through cognitive changes and memory loss. This is a progressive, neurodegenerative disease which is characterized by language deterioration, poor judgment, confusion, restlessness, mood swings, memory loss, and the inability to mentally manipulate visual information. The onset of Alzheimer’s disease generally begins around the mid-60s, but early signs may occur as early as in the early 40s. Some initial symptoms appear as memory decline, but as the illness progresses it starts to destroy cognition, personality, and the individual’s ability to function, along with restlessness and confusion. The severity, type, sequence,
Psychology is an applied as well as an academic field that studies both the human mind and behavior. The research in psychology attempts to explain and understand behavior, emotion and thought. The subject of psychology was created when Wilhelm Wundt opened up the very first psychology lab in Leipzig, Germany. Wilhelm Wundt believed that individuals who are appropriately trained would most likely be able to recognize the mental processes that are accompanied with feelings, thoughts and sensations (Wagner , 2009).
◦Memories are processed and stored in the cerebral cortex which is the largest, outermost part of the brain.
“ABNORMAL PHOSPHORYLATION OF A NON-PAIRED HELICAL FILAMENT POOL IN ALZHEIMER DISEASE*” is the primary source that I chose. Its target the readers who are interested in that subject or might want to do some researches about Alzheimer's disease, so they need to be informed about the processes that have been done as well as being aware of the results that came out. The reason why is that the first article has been examined specific group of people in order to know what is going on. There are set of experiments or an experiment with its results and discussions. The primary article, therefore, determines results that have been published for the first time.