Synthesis of Aspirin

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School

Technical University of Mombasa *

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Course

3421

Subject

Chemistry

Date

Nov 24, 2024

Type

docx

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12

Uploaded by CoachButterfly5975

1 SYNTHESIS OF ASPIRIN Student’s Name Institutional Affiliation Course Instructor’s Name Date
2 Synthesis of Aspirin Objective To react 2.1 gram of salicylic acid with 5 gram of acetic anhydride in the presence of concentrated sulphuric acid to form Aspirin. To prepare benzoic acid by reacting 5 gram of ethyl benzoate with 50 cm3 of sodium hydroxide, and finally test the purity of Aspirin and the functional group present. Materials and Equipment’s Thermometer Stopwatch Magnetic stirrer Erlenmeyer flask Test tube Dropper Clamp and stand Flat bottomed flask Beaker Buchner funnel Filter paper Spatula
3 Reflux apparatus Stirrer rod NAME FORMULA AND STRUCTURE MW (G/ ML) MP ( ) BP ( ) DENS ITY (G/C M3) COLOU R SOLID/L IQUID WATER H2O 18.0 2 0 100 1 colorless liquid ETHANOL C2H60 46.0 1 - 114. 5 78.5 0.789 colorless liquid SODIUM HYDROXIDE NaOH 39.9 97 318. 4 1388 2.13 white solid IRON (III) CHLORIDE FeCl3 162. 2 306 315 2.9 Dark green solid HYDROCHLORI C ACID HCl 36.4 58 - 114. 22 - 85.0 5 1.2 Colorless liquid CONCENTRATE D SULPHURIC ACID H2SO4 98.0 79 10 337 1.83 colorless liquid
4 SALICYLIC ACID C7H6O3 138. 12 211 158. 6 1.44 White crystals solid BENZOIC ACID C7H6O2 122. 12 122. 3 249. 2 1.27 colorless liquid METHYL BENZOATE C8H8O2 136. 15 -15 199 1.08 colorless liquid ASPIRIN C9H8O4 180. 158 135 140 1.4 White crystals solid ACETIC ANHYDRIDE C4H6O3 102. 09 - 73.1 139. 8 1.08 colorless liquid
5 Procedure Procedure observations 1. Weigh 2.1 gram of salicylic acid 2. Put this mass into an Erlenmeyer flask in a water bath maintained at 45 degrees Celsius to 50 degrees Celsius. 3. Add 5 ml of acetic anhydride into the Erlenmeyer flask. 4. Add a magnetic stirrer as the flask is in a heating mantle that allows stirring. 5. Add five drops of concentrated sulphuric acid. 6. Allow the Erlenmeyer flask to cool to allow the product to recrystallize. If it doesn't recrystallize, scratch the inside of the wall with an ice cube. Cloudy so formed 7. Add 30 ml of ice-cold water, and place it in the ice cubes. 8. Set the vacuum filtration apparatus 9. Transfer the solution into the Buchner funnel to allow filtration 10. Add 30 ml of water to the Buchner funnel will help to get rid of impurity. 11. Collect a tiny amount of residue for purity analysis 12. Add five ethanol to the filtrate on a
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