Which of the following is TRUE about carbon dioxide binding to hemoglobin?Carbon dioxide carbamoylates the N-terminus, stabilizing the T-stateCarbon dioxide binds to the central cavity in hemoglobin, stabilizing the T-state.Carbon dioxide, binds to the heme iron, stabilizing the T-state.None of the above are true.1 UNANSWEREDQUESTION 1/1SKIP FOR NOW14:03 / 14:11MacBook Pro

Hemoglobin: A multi subunits globular protein of Red blood cells which carries oxygenated blood to…

Answered: Which of the following is TRUE about…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter11: The Blood

Section: Chapter Questions

Problem 1SQE

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Which of the following are true of normal adult hemoglobin? Choice 1 of 4:can bind four Fe2+ ions Choice 2 of 4:can covalently bind four O2 molecules Choice 3 of 4:can adopt 2 different conformations, with different orientations of αβ dimers Choice 4 of 4:can bind four BPG molecules to stabilize the T state
Which of the following statements regarding the transport of oxygen by hemoglobin is correct? Upon binding of oxygen to heme, a shift in the position of the distal His ultimately induces the switch from T to R states When fully bound to oxygen, AG(R-state)
Answer the following questions about hemoglobin. The number of high affinity binding sites in the R form of hemoglobin is .The number of low affinity binding sites in the R form of hemoglobin is .The number of O2 molecules that need to bind to convert hemoglobin from the T to R form is .The number of high affinity binding sites in the T form of hemoglobin is .The number of low affinity binding sites in the T form of hemoglobin is
Which of the following is incorrect about 2,3-bisphosphoglycerate (BPG)? It is highly (-) charged b. It prevents binding of O₂ to hemoglobin Oc. It binds only to the relaxed (oxy) conformation of hemoglobin Od. It binds in the space between the four subunits of hemoglobin a.
Figure 5 shows oxyhemoglobin dissociatlon curves at pH 7.2 and pH 7.4. Which of the following is true at PO2 less than 40 mm Hg? 27. % saturation af haemogiobin 100 pH 7.4 80 60 pH 7.2 40 + 20 10 20 30 40 50 60 70 Po; (mm Hg) Figure 5 A. Hemoglobin retains less O2 at pH 7.4 compared to pH 7.2. B. Hemoglobin retains less O2 at pH 7.2 compared to pH 7.4. C. The release of O2 from hemoglobin is not influenced by the production of CO2. D. At pH 7.2 where CO2 production is less than pH 7.4, hemoglobin releases less O2.
Which of these occur when hemoglobin releases oxygen? Select all that apply. O Conformation is shifted toward the T-state BPG can bind in the central channel O Fe2+ is at the center of a planar heme group
In addition to O2 binding, changes in other chemical conditions can result in changes in hemoglobin structure and function. Increases in blood H+ result in oxygen binding curves for hemoglobin that are shifted to the right. The effect of H+ can be understood in terms of the equilibrium:H-Hb+ + O2 → Hb-O2 + H+How does the difference in pH in the lungs and tissues help hemoglobin do its job of delivering oxygen? Use the equilibrium equation in your argument.
Which of the following is FALSE about hemoglobin? O Hemoglobin only binds oxygen Every subunit of hemoglobin contains a heme group with an iron atom Hemoglobin contains four subunits As 02 molecules bind to hemoglobin, hemoglobin affinity for 02 increases All of the above are true
Mark any/all that are allosteric regulators of oxygen binding to hemoglobin. Group of answer choices 2,3-BPG H+ CO2
This graph shows the O2 binding curves of Hemoglobin. Which one is the R-state curve, and which one is the T-state? Why these curves are different comparing to the normal curve (middle one) 1.0 0.8 Observed hemoglobin- binding curve 0.6 0.4 0.2 0.0 50 100 150 200 p02 (torr) Y (fractional saturation)
he doctor also mentioned a new treatment for Sickle Cell Disease to JJ called Voxelotor (Oxbryta). Voxelotor binds to the a-globin chain and alters the structure of HbS stabilizing it in the R-state (relaxed state). Q7: In the presence of Voxelotor would you expect the affinity of HbS for O2 to increase or decrease? Q8: How would you classify the mechanism of action for Voxelotor? Q9: Voxelotor's structure is shown below. What would you expect the overall charge of the molecule to be in the blood (pH = 7.4) Pyridinium pKa = 2.6 Phenol pKa = 8.3
The part of hemoglobin that binds iron is O alpha globulin 2 Obeta globulin 2 alpha globulin 1 O beta globulin 1 heme

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