Answered: Part A and B A. What is the normal…

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 21QP

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Question

Part A and B

A. What is the normal function of the Rb protein?

A) Rb prevents the cell cycle from proceeding unless the cell is prepared to do so

B) Rb causes cells to undergo apoptosis

C) Rb promotes Cdk activation

D) Each of the other selections is true

E) Rb repairs damaged DNA

B. How do tumors arise?

A) When cell proliferation occurs at a higher rate than cell death

B) When someone is infected with a tumor from another person

C) When cell death occurs at a very high rate

D) When cell proliferation occurs at a very low rate

Expert Solution

Step 1

Answer A) Rb is Retinoblastoma protein which is a tumor suppressor protein and belongs to pocket protein family.

Step 2

Role of Rb protein;

Plays important role in negative control of cell cycle and further progression of tumor
Block S phase entry and growth of cell
Prevention of excessive cell growth by inhibition of cell cycle until a cell is ready to divide
When cell is ready to divide,Rb is phosphorylated to form pRb which results in inactivation of Rb.
Rb promotes cyclin dependant kinase (cDK) activation
Rb repairs damaged DNA

Hence all options are true

Step 3

So correct option is option D

D)Each of the other selections is true

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Part A and B A. What is the normal function of the Rb protein? A) Rb prevents the cell cycle from proceeding unless the cell is prepared to do so B) Rb causes cells to undergo apoptosis C) Rb promotes Cdk activation D) Each of the other selections is true E) Rb repairs damaged DNA