Myoglobin would be an inappropriate carrier of oxygen to peripheral tissues because: Myoglobin exists in the T, or deoxy state, in muscle tissue. Myoglobin would not release oxygen at the oxygen pressures found in muscle tissue. Myoglobin has lower affinity and would lose the oxygen to hemoglobin during transport. Myoglobin is only soluble in plasma. Two of the above.
Q: gives the turnover number of four representative enzymes. Enzyme Ribonuclease Fumarase Lactate…
A: Turnover number of an enzyme is defined as conversion of substrate molecules per second into its…
Q: An enzyme inhibitor that decreases the apparent KM and reduces the Vmax can be classified as an…
A: Enzymes are high molecular weight proteins that catalyse biochemical reactions. They contain an…
Q: A gel filtration column was calibrated by measuring elution volumes for two proteins of known mass:…
A: The established amounts of the elution volumes for the two proteins with determined masses can be…
Q: This question has been posted previously with parts A B and C already answered. Please focus on only…
A: Amino acids classified as hydrophobic have side chains (R groups) that have a propensity to resist…
Q: The reaction coordinate diagram shown below is for the mitochondrial enzyme ATP synthase. KJ/mol ATP…
A: A reaction coordination graph is a graphical representation of the free energy changes that occur…
Q: 1. Write the Michaelis-Menten equation (define all terms). Explain why this equation is valid only…
A: A chemical reaction known as a "enzyme-catalyzed reaction" is one in which a biological molecule…
Q: If a cell were given glucose labeled at carbon-3 with 14C, what carbon(s) of pyruvate would contain…
A: Glycolysis is a process by which a cell converts one glucose molecule to 2 molecules of pyruvate.…
Q: Succinylcholine is a fast-acting, short-duration muscle relaxant. Doctors use the chemical before…
A: Succinylcholine chloride is a short-acting depolarizing neuromuscular blocker, to be used in…
Q: What is the free energy change for the transport of calcium ions into a cell. The intracellular…
A: Free energy change (ΔG) of uncharged solute transport across a biological membrane can be calculated…
Q: What is the difference between fast and slow glycoly
A: Fast and slow glycolysis are two distinct metabolic pathways that cells employ to generate ATP…
Q: which region (ribose or base) could be modified to create an inhibitor ?
A: Inhibitors are the molecules or substances that result in inhibiting (stopping) the chemical or…
Q: What kind of ion exchange resin would be most effective for purifying RNA molecules, an anion…
A: The purification of RNA molecules is a critical step in many molecular biology and biotechnology…
Q: The concept of determining which reactant is limiting and which is in excess is akin to determining…
A: In a chemical reaction, the chemical species react with each other to yield the product(s).These…
Q: Draw a generic dipeptide, and write out the mechanism describing its cleavage catalyzed by a serine…
A: Serine proteases are protein cleaving enzymes that have Serine, Histidine and Aspartate (the…
Q: This is an image of double stranded DNA. Which red label in the above diagram is closest to the 5'…
A: DNA or the Deoxyribonucleic acids serves as the ge immaterial of almost all biological organisms…
Q: Diisopropylphosphofluoridate (DIPF) inactivates chymotrypsin by covalently modifying serine 195.…
A: Diisopropylphosphofluoridate (DIPF) is an irreversible inhibitor of chymotrypsin. It forms a…
Q: Classify the following descriptions of enzyme inhibition as either reversible inhibition or…
A: Enzymes are high molecular weight proteins that catalyse biochemical reactions. They contain an…
Q: Glucose oxidase [S] (glucose, mM) 0.1 5 7 8 15 20 0.2 0.4 0.5 1.0 2.0 3.0 5.0 7.5 35 45 55 60 80 90…
A: Enzymology relies on the fundamental idea of Michaelis-Menten kinetics. It covers the interactions…
Q: What is the length (in nm) of an alpha-helix containing 15 amino acid residues?
A: Proteins frequently contain an alpha-helix as a secondary structure. The polypeptide chain of the…
Q: A biochemist has 100 mL of a buffered solution at pH 7.5. The concentration of the buffer is 0.1 M,…
A: According to Henderson-Hasselbalch equation, find the ratio of acid and it's base.pH = pKa + log…
Q: complete the sentence In the Sanger method, the nitrogen from the tripeptide (give the name of the…
A: Sanger's reagent is used for sequencing of proteins. It is called as 1-fluoro-2,4 di Nitro benzene.…
Q: Are the given reactions examples of general acid/base catalysis, covalent catalysis, catalysis by…
A: Enzymes catalyze reactions using various types of mechanisms. Some of the most observed mechanisms…
Q: Define these aspects of bioenergetics: couple reactions, allosteric enzymes, activation energy
A: Bioenergetics is the field of biochemistry that deals with how cells convert energy, most often…
Q: ENZYME COMMISSION 1 2 3 4 5 сл 6 CLASSIFICATION BIOCHEMICAL PROPERTIES oxidoreductase Transferase…
A: Enzymes are proteinaceous substances that contribute to the precedence of a chemical reaction either…
Q: Assume a fragment of two-stranded antiparallel β-structure is 3.3 nm long. What is the approximate…
A: Deoxyribonucleic acid also known as DNA, is a molecule that houses the genetic instructions required…
Q: Chymotrypsin, trypsin, and elastase are digestive enzymes called serine proteases. The serine…
A: Aminoacids are classified based on the nature of their side chain. They areAcidic aminoacids :…
Q: What is mass fragmentography? How is this performed?
A: Mass fragmentography is also known by the name mass fragmentometric analysis or mass fragmentography…
Q: Using a biochemical technique called site-directed mutagenesis, it is possible to substitute a…
A: Site-directed mutagenesis is a method employed in the lab to perform accurate and deliberate…
Q: Hemoglobin has a pO2 = 100 Ťorr. Low; High High; High High; Low Low; Low binding affinity at pO2 =…
A: Haemoglobin (Hb) is a molecule composed of protein globin and a nonprotein component known as haem…
Q: Imagine you are able to incorporate a heavy isotope into the atoms of both strands of double…
A: Replication is a process wherein a daughter strand is synthesized using the parent's DNA strand. One…
Q: 1. Glycolysis can be summarized as a 6-carbon structure becoming two 3-carbon structures. To really…
A: In glycolysis, a 6-carbon molecule of glucose-6-phosphate is broken down into 3-carbon pyruvate. It…
Q: For this oligonucleotide, • Classify if RNA or DNA? Justify your choice. • Determine the sequence…
A: An oligonucleotide is a short sequence of nucleotides that is often made up of bases from DNA or…
Q: Case Study: Enzyme Kinetics Data for new statin drug (inhibits HMG CoA reductase): 1 Substrate (UM)…
A: For a one-substrate enzyme-catalyzed reaction, the Michaelis-Menton equation shows the quantitative…
Q: TPCK is a molecule with large hydrophobic groups. Why does TPCK inactivate chymotrypsin but not…
A: Proteases are enzymes responsible for cleaving peptide bonds. Chymotrypsin and trypsin are both…
Q: Order the compounds made of the following molecules by increasing melting point. molecule melting…
A: There are four types of biological macromolecule: proteins, nucleic acids, lipids and…
Q: DNA sometimes has chemical groups attached, called methyl groups, that affect gene expression.…
A: Methyl groups on DNA have a significant role in epigenetics and gene regulation and have a strong…
Q: Dextrose 5% in water solution is an example of hypertonic solution. True False?
A: Hypertonic solution is defined as the solution that contains high concentration of solutes than the…
Q: when calculating the Resting membrance potential using the goldman equation it is usally out, out…
A: The Goldman equation is often used to determine the resting membrane potential of a cell. It…
Q: 14-16. List the group (nonpolar, polar, acidic, or basic) for each of the following armino acids:…
A: Amino acids are broadly grouped into polar and nonpolar. Nonpolar amino acids can be further divided…
Q: The reaction coordinate diagram shown below is for the mitochondrial enzyme ATP synthase. G KJ/mol…
A: A reaction coordination graph is a graphical representation of the free energy changes that occur…
Q: Which of the following amino acids will bind to anion exchange resin at pH 7.0?
A: Anion-exchange chromatography is a type of ion exchange chromatography. Here the stationary phase…
Q: Transport of histidine into a bacterial cell was measured at several different histidine…
A: The kinetics of transport of a molecule via a carrier protein and a protein channel differ from each…
Q: Match the descriptions and compounds with the terms competitive, uncompetitive, and noncompetitive…
A: Enzymes are biological catalysts that increase the rate of biochemical reactions.Most enzymes are…
Q: What is the secondary structure of the peptide hormone GLP-1
A: GLP-1 (glucagon-like peptide 1) is a peptide hormone that is essential to control blood sugar…
Q: The graph shows three plots of velocity (Vo) versus substrate concentration ([S]). Determine which…
A: Enzymes are biological catalysts that increase rate of biochemical reactions.Most enzymes are…
Q: You have an initial solution in which you added quantities of “A” and “B” such that there is 4.5 M…
A: Since conditions inside the cell are different than standard temperature and pressure, biochemists…
Q: When transaminated, the three branched-chain amino acids (valine, leucine, and isoleucine) form…
A: Maple syrup urine disease is caused by a deficiency in the branched-chain α-keto acid dehydrogenase…
Q: The Lineweaver-Burk plot, which illustrates the reciprocal of the reaction rate (1/v) versus the…
A: The enzymes are biological catalysts that increase the rate of biochemical reactions.The enzyme…
Q: Glucose generally exists in ring (cyclic) form. A Haworth projection shows the orientations of the…
A: Glucose is a monosaccharide and classified as an aldohexose since it contain 6 carbon atoms along…
Trending now
This is a popular solution!
Step by step
Solved in 3 steps
- As the value of p50 myoglobin for oxygen rises, it falls, rises, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls, falls None of the aforementioned have a K _—- value, resulting in a strong affinity.Which of the following statements does NOT apply to the K value in the equation for the oxygen binding curve of myoglobin? It is numerically equal to p50. O A. It is defined as that oxygen partial pressure at which half of the oxygen binding sites are occupied. В. If Y> K, then myoglobin is less than 50% saturated with oxygen. OC. O D. It is a measure of the affinity of myoglobin for oxygen. OE. It is the value of po2 at which Y = 0.5.As the value of p50 myoglobin for oxygen. increases, decreases decreases, increases decreases, decreases increases, increases None of the above the value of K _--_, resulting in a high affinity of
- Myoglobin’s oxygen-binding curve exhibits a shape best described as— serpentine. hyperbolic. straight. sigmoidal. bell.Myoglobin and hemoglobin differ in... Question 30 options: the type of prosthetic group used their total oxygen binding capacity the number of sub-units present A and B B and CMatch the colour of myoglobin to the ligand bound. brown red pink 1. carbon monoxide 2. nitric oxide 3. water
- The shape for curve of oxygen binding to Myoglobin is ___________ and the shape for curve of oxygen binding to Hemoglobin is _________________ Hyperbolic, Hyperbolic Sigmoidal, Sigmoidal Flat, Sigmoidal Hyperbolic, SigmoidalPlease explain the difference between the oxygen dissociation curve created by myoglobin (asymptotic) versus the oxygen dissociation curve created by hemoglobin (sigmoidal). Why does this occur? Myoglobin O₂ saturation (%) 100 80 60 40 20 0 20 Hemoglobin 40 60 80 100 120 Po₂ (mmHg)Which of the following statements is correct of BOTH haemoglobin and myoglobin? Acidic conditions increase the affinity for oxygen. The iron atom of the heme prosthetic group is bound to nitrogen atoms at five of six coordination sites. Four oxygen molecules bind to each subunit. Quaternary structure is found in both haemoglobin and myoglobin. Both haemoglobin and myoglobin show the same oxygen binding affinity at different
- In 1913, Archibald Hill described an alternative formulation for cooperative processes such as the binding of oxygen by hemoglobin by considering the hypothetical equilibrium Hb+ n0₂ Hb(0₂)n 2 Analysis leads to the Hill equation: n p02₂" ( Y log (₁ x x ) = log Y (^_^) log where Y is the fractional saturation. This equation suggests that a plot of log with slope n. Plots for myoglobin and hemoglobin are shown here: 3 2 1 O -1 -2 -3 P50 + n = nlog (pO,) – n log(P5o) Myoglobin (0.25, -0.25) -1 0 1 2 log (pO₂) (3.0, 2.5) 3 4 (^_^) log 3 2 1 O -1 -2 -3 -4 (0, -3.4) -1 0 Y Y versus log (pO₂) should yield a line Hemoglobin (2.1, 2.5) - (0.7, -2.0) (1.9, 1.3) (0.4, -3.5) 1 2 log (pO₂) - (2.4, 2.4) 3 4Figure 6 shows the binding of oxygen to myoglobin and haemoglobin (Y-axis: Fraction saturation) when they are exposed to various partial pressures of oxygen (X-axis: pO2). 0.9 0.8 Myoglobin 0.7 0.6 0.5 0.4 Hemoglobin 0.3 0.2 0.1 2 10 12 Po, (kPa) Figure 6 (i) Briefly compare the protein structure of myoglobin to that of haemoglobin. (ii) Based on Figure 6, explain the differences between the functions performed by myoglobin and haemoglobin. Fraction saturationWhich of the following statements about oxygen transport is TRUE. Increases in temperature and decreases in pH cause myoglobin to release oxygen to improve delivery to the hemoglobin in muscles. A molecule of myoglobin has higher oxygen binding capacity than a molecule of hemoglobin. Myoglobin has a higher oxygen affinity than does hemoglobin. Fetal hemoglobin has a lower affinity for oxygen than maternal hemoglobin, which makes it better suited to extract oxygen from the maternal circulation.