If the proton-pump inhibitor, (S)-omeprazole, has a specific rotation (rotation of plane polarized light) of -155°, what should the specific rotation of (R)-omeprazole be? a) -155° b) 0° c) +155° d) It can only be determined experimentally
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- 3a. 3b. 3c 3d. 3e. CO₂ clavulanic acid CH₂-OH H Answer the following questions about clavulanic acid. Does clavulanic acid inhibit D-alanyl-D-alanine transpeptidase? Does clavulanic acid contain a ß-lactam? Does clavulanic acid contain a thiazolium ring? What is the result of the treatment of penicillinase with clavulanic acid? Does clavulanic acid form a covalent acyl-enzyme intermediate with penicillinase?2. Flavopiridol was the first semi-synthetic cyclin-dependent kinase inhibitor to be tested in clinical trials. Research has shown that co-administration of flavopiridol with drugs such as the taxanes had synergistic cytotoxic effects against a variety of tumour cells. HO но. HO CI 2.2 Name two classes of compounds that appear in the structure of flavopiridol.How can we decide whether an observed rotation of a solution of an optically active compound is +170° and not actually -190°?
- 1. Draw structures for the following: (a) N,N-dimethylpentanamide (b) Acetamide(c) 2,3-dimethylpentanamide (d) N-ethylbenzamideDRAW THE CHEMICAL STRUCTURE OF THE FOLLOWING:1) Methyl 5-methyl-6-oxohexanoate2) 5-Amino-3-methylpentan-2-ol3) Isopropyl 3-hydroxypropanoate4) 3-Oxocyclohexanecarbaldehyde5) 5-Methyl-6-oxohexanamide6) p-Chloromethylbenzene7) 2,5,5-Trimethyl-4-oxohept-2-enoic acidThalidomide exists in two enantiomeric isomers as shown below. N (R) NI(S) O If a solution is prepared by adding a 50:50 ratio of two enantiomers what will be the expected observed rotation? Explain your answer in 1-2 sentences.
- Note: enantiomers have similar physical properties (mp, density, solubility), and same [a], but with different signs ( - or +). Practice: 1.2 gm sample of cocaine, [a], = -16º, was dissolved in 7.5 mL of chloroform and placed in a sample tube having a pathlength of 5 cm. what was the observed rotation in degrees?BCX4430 is active against the Ebola virus. What class of drugs would BCX4430 belong to and suggest a mechanism of action of this drug. H2N HN- N. НО НО OHCalculate the degree of unsaturation in each of the following formulas (a) Cholesterol, C27H46o (b) DDT, C14HgC15 (c) Prostaglandin E1, C2oH3405 (d) Caffeine, C8H10N402 (e) Cortisone, C21H28O5 (f) Atropine, C17H23NO3
- Look up the structure of lisdexamfetamine (Vyvanse), a drug used in the treatment of attention deficit hyperactivity disorder (ADHD). Redraw it and identify all the functional groups present. What is known about itstherapeutic properties?Given that C6H11COOH has a pKa = 4.8 and C6H11N+H3 has a pKa = 10.7, (a) What pH would you make the water layer to cause the carboxylic acid to dissolve in the water layer and the amine to dissolve in the ether layer? (b) What pH would you make the water layer to cause the carboxylic acid to dissolve in the ether layer and the amine to dissolve in the water layer?Why are azo compounds good building blocks for organic dyes because aromatic azo compounds have alternating C-C and C=C bonds azo coupling removes the N-N triple bond azo coupling generates new C=C bonds O Azo coupling makes a longer conjugation system