discuss the G-protein coupled receptors structure and overview of G-protein dependent signaling mechanism?
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discuss the G-protein coupled receptors structure and overview of G-protein dependent signaling mechanism?
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- What are g-coupled protein receptors? Explain the role they play in cell physiology.Describe the common architecture of G protein-coupled receptors. Illustrate your answer with reference to the domains that facilitate signal transduction across the plasma membranePane Create a diagram which illustrates the typical signalling mechanism of action of g protein coupled and possible routes of communication (autocrine etc.). Should show the specific molecules involved, the mechanisms of signal transduction and indicate the different pathways that are activated. It should include a specific example of a receptor, ligand and signalling pathway for each general class. Include as wide a variety of ligands and modes of action as you can. for a novel pathway. Superfamily Give the superfamily to which the receptor belongs Accession Give the Uniprot accession number Name Give the molecule name Species Give the species Ligand What is the ligand, or class of ligands which bind to this receptor? Key What are the physiological processes involved? Is this autocrine, physiological paracrine or endocrine or some combination of them? What is the pathology of the receptor? process involved What are the downstream actions of the receptor? Which molecules does it…
- What are the two general possible signaling pathways follow after a G-protein coupled receptor binds to its ligand molecules involved that can listExplain how G Protein Coupled receptors activate G proteins and how RGS (Regulator of G Protein Signaling) inactivate G proteins.. which of the following statements about heterotrimetric G proteins and their receptors is incorrect? A: when GTP binds to the alpha subunit of the G protein, the beta-gamma subunit dissociates from the alpha subunit B: G-protein coupled receptors contain nine transmembrane alpha helices C: binding of arrestin causes removal of the receptor from the membrane D: G protein- coupled receptors may be desensitized by serine phosphorylation I had chosen option A and got it wrong. What is the Correct answer and explain how it is. Also, where did i go wrong in choosing option A?
- Discuss Signaling by Receptors that Interact with Cytoplasmic Janus Kinases?What are G-protein coupled receptors? How does ligand binding activates GPCR (include in your answer, the types of G-proteins and the second messenger systems involved in the translation of a pharmacological response when a ligand binds to GPCR)?Draw the general structural features of a G-protein coupled receptor (GPCR)
- Create a diagram which illustrates the typical signaling mechanism of action of g protein coupled land possible routes of communication (autocrine etc.). Should show the specific molecules involved, the mechanisms of signal transduction and indicate the different pathways that are activated. It should include a specific example of a receptor, ligand and signalling pathway for each general class. Include as wide a variety of ligands and modes of action as you can. for a novel pathway.Discuss the regulation, role, and cellular localisation of named protein kinases active in specified G protein-coupled receptor signalling pathways.1a) Create a diagram which illustrates the typical signaling mechanism of action G protein-coupled receptors and possible routes of communication (autocrine etc.). Should show the specific molecules involved, the mechanisms of signal transduction and indicate the different pathways that are activated. It should include a specific example of a receptor, ligand and signalling pathway for each general class. Include as wide a variety of ligands and modes of action as you can for a novel pathway.