Discuss the following mutations with reference to specific genetic disorders: i) Faulty DNA repair; ii) Gain-of-function; and iii) Trinucleotide repeats. Give steps for each mutations.
Q: What types of mutations are possible?
A: Mutation It refers to the alteration in the sequence of DNA. It results from the mistakes during the…
Q: What is a spontaneous mutation, and why are spontaneous mutations rare?
A: The mutation is the sudden deleterious effects in the DNA sequences, they can arise when the DNA is…
Q: What are the effects of Sxl mutations?
A: Mutations are defined as the change in the sequence of DNA of an organism due to any environmental…
Q: What are Antimorphic mutations ?
A: Mutations are the alterations or the changes that occur in the DNA. Mutagens are the agents that are…
Q: What are the three main steps for repairing the DNA damages such as the deamination of cytosine…
A: Despite the elaborate proof-reading employed during DNA synthesis, erros can occur. In addition, DNA…
Q: What is a mutation? How does a mutation lead to an altered phenotype? Describe two specific types of…
A: The cell is the basic structural and functional unit of the body. A cell is composed of various cell…
Q: What is the difference between a germline mutation and a somatic mutation?
A: A mutation is a biological process occurring in the Deoxyribonucleic acid (DNA) sequence due to…
Q: What are the three types of point mutations?
A: Chromosomal mutations involve changes in the entire chromosomes. Point mutations are the changes in…
Q: What are the types of mutations, and how does each alter theencoded protein?
A: Mutations are the changes in the genome resulting in synthesis of different products. These changes…
Q: Give some function of mutation?
A: The cell biology is considered as the study of cells, their structure, cell division, and their…
Q: describe the different types of mutations?
A: Genetic material is nothing but the sequence of nucleic acids which is called as DNA. It contains…
Q: Which type of mutation has the nighest mutation rate?
A: A mutation is a change in our DNA sequence that occur as a result of errors in DNA copying or…
Q: (b) How many forms can naturally occurring DNA exist in? Explain how these forms are characterized.…
A: DNA Deoxyribonucleic acid Genetic material in many species Has ds(double stranded) structure…
Q: What is a A hypomorphic mutation?
A: The change in normal structure or function of a wild type of gene due to alteration in nucleotides,…
Q: • What is the causative gene mutation in these diseases? • What amino acid and/or protein domain is…
A: this is a multipart question and according to our guidelines we are allowed to answer only 3 parts…
Q: What is a mutation and how are mutations related to genetic diseases?
A: Gene expression is the process in which information stored in DNA is converted into functional…
Q: Define what are DNA replication errors ?
A: DNA replication is the biological mechanism in which two similar replicas of DNA are generated from…
Q: What are neomorphic mutations?
A: Any permanent change in the DNA’s nucleotide sequence is termed as mutations. Based on their effect…
Q: How to identify all the somatic mutationswithin tumors ?
A: A somatic mutation is a modification within the desoxyribonucleic acid sequence of a somatic cell of…
Q: What is a point mutation?
A: The genome of an individual determines its identity. It is composed of a unique DNA…
Q: Which of the following is TRUE regarding point mutations?
A: Answer - Option D - Insertions and deletions can be more harmful than substitutions because they can…
Q: Which form of Retinoblastoma typically results in unilateral disease and exhibits 2-hit mutational…
A: Retinoblastoma is a cancer that affects the eyes. It is specifically a cancer of retinal layer of…
Q: What is the effect of lacI- mutations?
A: The lactose operon or lac operon is an inducible operon system under dual – positive and negative…
Q: which word describes the majority of permanent genetic mutations?
A: A mutation is a change in our DNA sequence that happens as a result of errors in DNA copying or…
Q: What are the factors that cause mutation?
A: A spontaneous molecular alteration in a gene's DNA sequence is known as mutation. There are various…
Q: Can Spontaneous mutations occur without the action of extraneous agents ?
A: DNA (deoxyribonucleic acid) is the genetic material of almost all living organisms. It is a double…
Q: Define about missense mutation ?
A: Mutations are changes in the DNA base sequence of any genome. Mutations can be caused naturally due…
Q: Explain disease-causative mutations with examples
A: The term mutation is defined as any type of change in deoxyribonucleic acid (DNA). It can be caused…
Q: List out the main types of DNA damage that occur below and major cause of this type of mutation. How…
A: DNA damage is a change in the basic structure of DNA. Damage can be addition of the bases , removal…
Q: what is reverse mutation?
A: The deoxyribonucleic acid (DNA) is the hereditary unit of an organism composed of the nucleotides…
Q: Explain the DNA repair defects .
A: DNA repair is a process in which cell identifies any defect in the DNA and correct it. Cells cannot…
Q: Which is generally more serious—a missense mutation or a nonsense mutation?
A: A mutation occurs/happens when the sequence/structure of DNA is altered. Mutations can occur as a…
Q: What are the chances of occurence of amorphic mutation?
A: Mutations are defined as the change in the sequence of DNA of an organism due to any environmental…
Q: Give the examples of Human Disorders Caused by Single-Gene Mutations ?
A: A single gene disorder is caused by mutations in the DNA sequence of a specific gene or at an…
Q: What type of mutation is shown below:
A: Structural chromosomal mutations refer to the changes in structure of a chromosome due to insertion,…
Q: Discuss the changes in chromosomes that contribute to the mutations tabulated in Table above
A: A mutation is a change in the nucleotide sequence of DNA that occurs suddenly and permanently. It…
Q: What are Somatic mutations ?
A: Answer- Mutation is any genetic change in the sequence of the DNA that may lead into abnormality in…
Q: Explain the effect of lacI− mutations?
A: The lactose operon codes for the enzymes that are involved in the catabolism of lactose compounds.…
Q: List three ways in which spontaneous mutations might arise.
A: A mutation is an adjustment in the nucleotide succession of the genome of a life form, infection, or…
Q: What is targeted mutation?
A: Mutation means sudden changes occur in DNA sequences. The mutation occurs randomly. It also occurs…
Q: What are the chances of occurrence of hypomorphic mutation?
A: Mutation is defined as the sudden inheritable change that occurs in the DNA sequence. It is caused…
Q: What is dominant mutation ?
A: A dominant gene or a dominant version of a gene is a particular variant of a gene which expresses…
Q: What Is the Molecular Basis of Mutation?
A: Introduction Mutations in the genes may be caused artificially or occur naturally. When an organism…
Q: Which class of mutation, missense or nonsense, is morecommon, and why?
A: Nonsense Mutation when there occurs deletion or insertion of single nucleotide base in the gene then…
Q: Describe the different kinds of mutations.
A: A mutation is an adjustment in the nucleotide succession of the genome of an organic entity,…
Q: Does The Effects of a Mutation Can Be Difficult to Predict?
A: A mutation is a change that occurs in the deoxyribonucleic acid (DNA) when it is damaged or changed…
Q: What type of mutations are insertions and deletions?
A: The biochemical material that is carried from the preceding generation to the succeeding generations…
Discuss the following mutations with reference to specific genetic disorders: i) Faulty
DNA repair; ii) Gain-of-function; and iii) Trinucleotide repeats.
Give steps for each mutations.
Step by step
Solved in 5 steps
- Find non-cancerous, non--nonsense, point mutation genetic disease. Describe the disease's name and the type of mutation. Compare the gene sequence between wild type and mutant. Compare the polypeptide sequence and structure encoded by the wild type's gene and the mutant's gene. Describe and explain the consequences of the mutation to a patient's health. Note: 1. These questions will test the concepts of DNA-Protein transcription and translation on the effects of mutation. 2. Using dissimilar example/solution from your classmate and lecture's notes is encouraged. 3. Provide citation and reference.What are the three possible effects on the cell (or organism) when a mutation occurs in DNA? Which ones are most common? Which one is rare?IDENTIFY THE MUTATED mRNA, AMINO ACID, AND THE TYPE OF MUTATION OCCURRED ON NORMAL DNA.
- Two types of mutations are (1) nucleotide changes and (2) unstable genome regions that undergo dynamic changes. Describe each type of mutation.define the term name as Missense mutations(b): How many forms can naturally occurring DNA exist in? Explain how these forms are characterized. What properties of the functional groups determine the binding of DNA with anti-cancer agents? Explain.
- Given the following Wild Type and Mutated DNA sequences: 1.) Identify where the base pair change occurs (what letters changed?) 2.) For BOTH sequences, write the mRNA strands, define the codon regions (with spaces), and amino acid sequences. 3.) Describe what kind of mutation has occurred (missense, nonsense, or silent), and what effect this may have on the protein. Wild Type DNA Sequence: 3' - CCTCGTTATGTG - 5' Mutated DNA Sequence: 3' - CCTCGTTATTTG - 5'Two types of mutations discussed in this chapter are 1) nucleotide changes and 2) unstable genome regions that undergo dynamic changes. Describe each type of mutation.Silent mutations that occur in DNA are quite common in living cells and usually involve no effects on phenotype. In not more than 2 pages (using 1.5 line space of Arial or Times New Roman fonts) provide answers for the following questions? 1) Define the silent mutation in DNA? 2) What is the codon usage bias? 3) Provide one example of a clinical implication of a “silent mutation” that proven to have an effect on the phenotype andprovide a brief description of its molecular characteristics? (Explain in details)