Citrate synthase is inhibited by: NAD+ ADP NADH oxleoacetate All of the above None of the above
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- ATP, like ADP and AMP, is a competitive inhibitor of NADH binding to malate dehydrogenase. Provide a structural explanation for this inhibition.Identify the Krebs cycle enzyme that consumes a 3-carbon substrate molecule, producing a 2- carbon product molecule (attached to acetyl-CoA), along with NADH, and one molecule of CO2. succinyl CoA synthetase a-ketoglutarate dehydrogenase pyruvate dehydrogenase isocitrate dehydrogenase malate dehydrogenasePyruvate can enter the TCA cycle via two enzymatic reactions. Provide a simplified schematic presentation of the TCA cycle to show this. Also indicate how these reactions are regulated.
- Which of the following is NOT a cofactor for the pyruvate dehydrogenase complex? Lipoate COA FAD NADP+ All of the above are cofactors for the PDH complex.The enzyme is considered to be alan * ÇOO ÇOO Lactate dehydrogenase HO-C-H+ NAD C=0 + NADH + H CH: Pyruvate Lactate O Oxydoreductase O Isomerase O Hydrolase O Ligase O DehydrataseOf the allosteric enzymes listed below, which are suppressed by NADH? Select all that apply. the pyruvate dehydrogenase complex a-ketoglutarate dehydrogenase complex U isocitrate dehydrogenase pyruvate kinase Ophosphofructokinase hexokinase Oglucokinase
- In the pyruvae dehydrogensae complex, acetyl-coa is released by the dihydrolipoyl transacetylase activity. What is the purpose of the following enzymatic activity.The tricarboxylate transport system supplies cytosolic acetyl-CoA for palmitate synthesis. What percentage of the NADPH required for palmitate synthesis is thereby provided?One of the consequences of ethanol addiction is fattyliver disease, an illness in which liver cells accumulatetriacylglycerols, the esters derived from glycerol and fattyacids. Ethanol is oxidized in the cytoplasm of liver cells byalcohol dehydrogenase and aldehyde dehydrogenase to yieldacetate and 2 NADH. Acetate is then transported into themitochondrion, where it is converted to acetyl-CoA andmetabolized by the citric acid cycle. When alcohol is consumed in excessive quantities, the resulting high levels ofNADH cause metabolic abnormalities, one of which is highlevels of fatty acid synthesis. Fatty acid synthesis, also acytoplasmic process, uses acetyl-CoA as a substrate andNADPH as a reducing agent. Determine how a high level ofcytoplasmic NADH provides a source of NADPH for fattyacid synthesis.
- Which of the following glycolytic enzymes catalyzes the conversion of fructose-1,6-bisphosphate into the two product molecules dihydroxyacetone phosphate, and glyceraldehyde-3-phosphate? phosphoglycerate kinase pyruvate kinase malate dehydrogenase aldolase phosphofructokinaseWhich enzyme is used for both the synthesis and breakdown of acetoacetate? thiolase O HMG-CoA synthase OB-hydroxybutyrate dehydrogenase O B-Ketoacyl-CoA transferaseGive the number of the following:a. number of acetyl-CoA that enters the TCA cycle for every 5 molecules of glucoseb. number of high-energy phosphate groups required for the complete formation of glucose during gluconeogenesisc. number of NADPH produced for each molecule of glucose in the pentose phosphate pathway