ATP levels are high in the liver, NADPH levels are low, but fat biosynthesis needs to happen. What is the function of the pentose phosphate pathway?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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ATP levels are high in the liver, NADPH levels are low, but fat biosynthesis needs to happen. What is the function of the pentose phosphate pathway?

 
Mode 1 - NADPH and ribose 5-phosphate are being generated
Mode 2 - ribose 5-phosphate is needed, so only the non-oxidative portion is being used for carbon skeleton rearrangments
Mode 3 - NADPH is needed, so oxidative portion is operating to make NADPH and non-oxidative portion is operating to regenerate glucose 6-phosphate
Mode 4 - NADPH and ATP are needed, so oxidative portion makes NADPH, non-oxidative portion does carbon skeleton rearrangements to fuel glycolysis and make ATP
 
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The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P). 

 

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