ACH ACH + ACH + ACH + 1 x 10-M 3 x 10-M Acetylcholine Alone Concentration [Molar] Homatropine Homatropine Homatropine 3 x 10-⁹M 3 x 109 3 +/- 1 6 x 10-9 8 +/- 3 No response 3 x 10-8 28 +/- 6 10 +/- 4 No response 6 x 10-8 38 +/-8 21 +/-9 5+/-2 No response 3 x 10-7 55 +/- 5 43 +/- 7 27 +/-9 10 +/- 4 6 x 107 56 +/- 5 52 +/-3 38 +/- 7 20 +/- 7 3 x 10-6 55 +/- 4 53 +/- 6 43 +/- 6 6 x 106 56 +/- 2 54 +/- 5
ACH ACH + ACH + ACH + 1 x 10-M 3 x 10-M Acetylcholine Alone Concentration [Molar] Homatropine Homatropine Homatropine 3 x 10-⁹M 3 x 109 3 +/- 1 6 x 10-9 8 +/- 3 No response 3 x 10-8 28 +/- 6 10 +/- 4 No response 6 x 10-8 38 +/-8 21 +/-9 5+/-2 No response 3 x 10-7 55 +/- 5 43 +/- 7 27 +/-9 10 +/- 4 6 x 107 56 +/- 5 52 +/-3 38 +/- 7 20 +/- 7 3 x 10-6 55 +/- 4 53 +/- 6 43 +/- 6 6 x 106 56 +/- 2 54 +/- 5
Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter31: Immunochemistry
Section: Chapter Questions
Problem 31.70P
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Question
Below are responses generated using the isolated guinea-pig ileum preparation to determine a pA2 value for the cholinergic antagonist homatropine.
Responses are expressed in millimetres +/- SDM (n = 4).
1. Plot the data on a sheet of paper and then determine by Schild analysis the pA2 value and Schild slope
2. show all calculation on a table form on a sheet of paper
3. discuss the result with conclusion
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