1. Show the products of the reductive amination reactions below: a) Acetone + NH3, followed by H2/Ni2 b) Acetone + CH3NH2, followed by LIBH3CN c) Acetone + (CH3)2NH, followed by LIBH3CN
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- 6. The reaction between aniline and nitrous acid at low temperature yields A) an N-nitroso amine B) a diazonium salt C) a nitrile D) an amine nitrite salt 7. An organic nitrogen compound, X, gives ammonia on warming with dilute aqueous sodium hydroxide, X could be A) ethanamide B) ethylamine C) phenylamine D) amino ethanoic acidWhen a compound like napihthalene C1oHa is dissolved in t-butyl methyl ether, then that solution is extracted with 3 M NaOH, and then the resulting basic aqueous layer is acidified with 6M HCI, what happens to the acidified aqueous layer? a) The naphthalene stays in the the aqueous layer as C10Ha O b) The naphthalene precipitates out as a solid, C10He O C) Nothing happens to the aqueous layer other than a dramatic raising of the pH d) The naphthalene stays in the aqueous layer as C10H>Na O e) Nothing happens to the aqueous layer other than a dramatic lowering of the pH O) The acid precipitates out as a solid, C10H>NaC) a nitrile D) an amine nitrite salt DIRECTIONS: Each of the following questions or incomplete statements below is followed by four suggested answers lettered A - D. Select or choose the letters of the best answer to the question or incomplete statement. 7. An organic nitrogen compound, X, gives ammonia on warming with dilute aqueous sodium hydroxide, X could be A) ethanamide B) ethylamine C) phenylamine D) amino ethanoic acid Which one of the following reagents reacts 1. in a similar fashion with both phenylamine (C H,NH,) and ethylamine. A) Br,(aq) C) conc. HNO, D) cold HNO (aq) 2. Phenylamine (aniline) can be prepared by reducing nitrobenzene with tin and concerntrated hydrochloric acid followed by the addition of alkali and finally steam distillation. The alkali is added to; A) prevent oxidation of phenylamine. B) liberate free phenylamine from solution C) dissolve excess nitro benzene D) dissolve the phenylamine 8. Arrange the following molecules in their increasing order of base…
- Choose exactly 3 answers from the choices 1. Nitrogen-containing functional groups: AmidesThiolsAzo dyesAmines 2. Carbonyl-containing functional groups: AldehydesEthersKetonesCarboxylic acids 3. Structural components/groups present in Ethoxymethane: Methyl groupEthyl groupOxygenEster linkage4) Rank the following compounds in order of increasing reactivity (least to most reactive) with respect to acyl substitution. I. methyl benzoate II. benzoylchloride III. benzamide III < | < ||H₂N Provide the missing structures. NH2 CH3 1) DCC N. 2) LIAIH 3) H₂O Boc₂O (1 equiv) The aliphatic amine is a stronger base/nucleophile. Why
- a) What are the difficulties with the following reaction to synthesize an amine. + HBr Br + NH3 NH2 b) Show a possible alternatives to this synthesis.I) Sketch a stepwise mechanism for the reaction of secondary amine with an acid chloride to generate an amide and H-CI II) Name the general class of organic compound that each of these molecules belong to i) R NR2 ii) R ii1) iv) R-CEN1. Arrange the test samples in order of increasing reactivity with sodium bicarbonate? Explain briefly -Ethanoic acid, Butanoic acid, Benzoic acid 2. Arrange the test samples in order of increasing solubility in water? Explain briefly. -Ethylamine, Diethylamine, Aniline 3. Arrange the test samples in order of increasing basicity? Explain briefly. -NaOH, Ethylamine, Aniline
- i) 3-methyloctane-2,3-diol 11) 3-chloro-4-ethoxy-2-methylcyclopentanamine iii) N, N, 3,3-tetramethylbutan-2-amine iv) 1-ethoxy-2,5-difluorohexan-3-ol 6) 5-isopropoxy-3-isopropyl-6-propoxy-4-propylcyclohexane -1, 2-diol draw of the following names in skeletal formsWrite the mechanism for the following reactions: 1. the acid-catalyzed hydrolysis of an imine to a carbonyl compound and a primary amine 2. the acid-catalyzed hydrolysis of an enamine to a carbonyl compound and a secondary amine a. How do the two mechanisms differ?Give the major product for the reaction. Pyrrolidine is a secondary amine. CH CH O CH CH! O OH CH2 O CH. I CH.CH Ї TCH CHE OH CH CH₂CH₂ CH.CH CH.OH2 0= RO pyrrolidine. 2 GH CH2 3 HCI H,0 TOH OH: CH₂CH₂ TCH CH: CH₂CH. CH₂CH₂