Monday 4th February 2016. Acid base balance and Renal function
The study of the renal system was completely new for me. I have already studying the renal structure but not in depth. And I
Most of the aspect of this unit were new for me although I already knew the structure of the renal system I did not know about th
The main role of the kidneys is to regulate body fluids within narrow limits by maintaining homeostasis (preservation of an internal environment), interacting with the endocrine system and excreting metabolic waste. To maintain homeostatic regulation electrolytes and balance of acid-base is an essential necessity which is controlled by the kidneys.
The pH of arterial blood is regulated by the actions of two organs – which are
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Sodium is the major cation (positively charged ion) which is present in the ECF. The normal range for sodium is 135-145mEq/L. Sodium plays a role in fluid balance, osmotic pressure, muscle contraction and can be regulated by a sodium-potassium pump. When there are deficiencies in sodium (i.e. 145mEq/L) are known as hypernatremia. The kidneys try to counteract this by secreting ADH to retain water. Hyperaldosteronism (increased aldosterone levels which increase sodium reabsorption) can be another cause of hypernatremia. Other causes can include excessive fluid loss, high salt intake and increased kidney reabsorption. Symptoms of hypernatremia include dehydration, fever or coma.
Overall regulating electrolytes are vital to maintaining a balance in keeping homeostatic conditions. Acid-base balance must also be sustained to enable maximum function of the kidneys. Both electrolytes and acid-base balance are important components regulated by the kidney and lungs to some extent; and keeping equilibrium and balanced levels will be beneficial for a healthy functionality of the kidneys.
References:
Byrne, C. and Cove-Smith, A. (2015). Clinical assessment of renal disease. Medicine, 43(7), pp.361-367.
Chadwick, L. and Macnab, R. (2015). Laboratory tests of renal function. Anaesthesia & Intensive Care Medicine, 16(6), pp.257-261.
Edwards, S. (2008). Pathophysiology of acid base balance: The theory
Potassium works with sodium to regulate the body’s water balance. The kidneys help to control the blood pressure by controlling the amount of fluid stored in the body. Therefore, the more fluid then the higher the blood pressure is. The kidneys do this by filtering out the blood and extracting any extra fluid, which then is stored in the bladder as urine. This is done very delicately as both sodium and potassium pull the water across the wall of the cells from the bloodstream into a collecting channel that leads to the bladder. When eating to much salt, the amount of sodium in the bloodstream will be imbalanced compared to the amount of potassium and thus reducing the ability of the kidneys remove the extra fluid. Eating more fruit and vegetables, the potassium levels increase and can help restore the chemical imbalance. However, there is a possibility of too much potassium, also known as hyperkalemia, which can lead to other issues like renal failure.
Electrolyte balance is also a crucial aspect in maintaining homeostasis in the body. According to McCance, the
The body needs to maintain equilibrium to function properly in everyday life. The most important substance it must regulate is water; water is everywhere in our body and its balance is essential for proper body function.
The physiological overview involves the kidneys processing blood by eliminating any excess mineral salts, urea and water as this provides homeostasis and it enables the body to work effectively. The nephron (which is part of the kidneys) for
If there is more NA it the ATPase will have trouble pumping correctly causing problems in the kidneys
3.An example of the urinary system working with the respiratory system to regulate blood pH would be
The kidneys act as chemical factories of the body and have many functions. They act in balancing the level of water within the body, regulating the concentration of important ions such as sodium, chloride, potassium, calcium, and others, maintaining blood plasma volume, maintaining the proper acid-base balance in the body, excreting waste products of metabolism as well as foreign compounds, and to produce hormones. Their primary functional unit is a nephron and is the smallest unit capable of producing
Regulate blood pressure and kidney function. Producing erythropoeitin. Metabolizing vitamin D to its active form.
* 8. What was the mean severity for renal disease for the research subjects? What was the dispersion or variability of the renal disease severity scores? Did the severity scores vary significantly between the control and the experimental groups? Is this important? Provide a rationale for your answer.
Brenner (2007) explained that the primary function of the kidneys is to excrete waste products resulting from metabolism by filtering them out of the bloodstream into urine. The kidneys also have many homeostatic functions such as maintaining acid-base homeostasis and electrolyte concentrations, and regulating plasma osmolarity and blood pressure (Brenner, 2007). The kidneys secret and interact with a variety of hormones such as
The purpose of this virtual lab is to observe the acid-base balance in the urinary system by how PCO2 and blood pH affect the H+ and HCO3- in the urine. The renal compensation is a mechanism that shows the kidneys manage to change pH in correct way if the respiratory system is not healthy. The kidneys are two organs that help remove wastes and extra fluids out of the body. The acid-base balance is when the blood need to keep the balance of
According to American Cancer Society, in our bodies most people are born with two bean shaped organs, found attached to the back wall of the abdomen, these are called kidneys. As you grow in life your kidneys have multiple jobs, but the biggest job is that they act as a filter in your body. They will take in the blood and filter any substance not needed, such as excess water, salt, and other waste. Once the process of filtering anything bad begins, your kidneys will kick out what we know as urine. American Cancer Society says the kidneys will also “help keep your blood pressure controlled”, by making a hormone called, renin. Need more red blood cells? Don’t worry, your kidneys will make another hormone, known as erythropoietin, sending a message
Metabolic acidosis results from all conditions that decrease the pH of the body fluids below 7.35 and HCO3- levels are <22 mEq/L, with the exception of conditions resulting from altered function of the respiratory system. As hydrogen ions accumulate in the body fluids, buffers first resist a decline in pH. If the buffers cannot compensate for the increase in hydrogen ions, the respiratory center helps regulate the body fluid pH. The reduced pH stimulates the respiratory center, which causes hyperventilation. During hyperventilation, carbon dioxide is eliminated at a greater rate. The elimination of carbon dioxide also eliminates excess hydrogen ions and helps maintain the pH of the body fluids within a normal range. (Angus, 2006)
There is a pair of kidneys in the human body. They are situated towards the back of the body under the ribs, just at the level of the waist where one on either side of the body. Each kidney is composed of about one million units which are called nephrons and each nephron consists of two parts: a filter which is called the glomerulus and a tubule leading out from the nephron (Cameron 1999). According to Marshall and Bangert (2008) the kidneys have three major functions. Firstly, the kidneys are excretion of waste from plasma in the blood. The second function is that, they maintain of extracellular fluid volume and composition. Lastly, the kidneys have a role in hormone synthesis.
The human body contains blood and fluid compounds and elements like chloride, phosphate, potassium, calcium, sodium, and magnesium known as electrolytes that occur naturally to control important physiologic functions. When the body levels of electrolytes are low (hypo) or high (hyper) it results in electrolyte disorder. Depending on the affected electrolyte(s), when body electrolytes are hyper (high) or hypo(low) it leads to electrolyte disorder, which in turn disrupts blood ionized salts balance ( Buttaro, et al., 2017). For instance, disruption of chloride leads to either hyperchloremia or hypochloremia, calcium (hypercalcemia or hypocalcemia ), Potassium (hyperkalemia or hypokalemia), Magnesium disruption