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Why are neuronal cells in particular more sensitive to oxidative stress?
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- Give typing answers only no handwritten answers please......What compounds or probes could you use to investigate (a) G-protein–mediated signal transduction, (b) nitric oxide signal transduction, and (c) calcium ion-dependent fluxes and effects.SOLVE STEP BY STEP IN DIGITAL FORMAT Oxygen is important for cell function and oxygen exchange is a normal phenomenon for oxidative phosphorylation in mitochondria, so how does it become malicious for neuronal cells? USE QUANTUM MECHANICS AND BIOCHEMISTRY
- Discuss reuptake and enzymatic degradation (breakdown) in the context of the appropriate neurotransmitters. Please include peer reviewed references.Ion channel-coupled receptors • G-protein-coupled receptors • Enzyme-linked receptors • Briefly describe what a G-protein is (explain by using the words GTPase, GTP and GDT) • Briefly describe how a G-protein-coupled receptor for the signal / information further into • Briefly describe how an enzyme-linked receptor carries the signal / information further into the cell.What is NAGPRA? why is it important?
- Paper link - https://www.jneurosci.org/content/40/8/1756.long Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation What is LPS (not just what does it stand for)? Why is it used as a model for neuroinflammation? Describe microglia: where are they found, what role do they play, why can't that role be carried out the same way it is in the rest of the body? Mitofusin2 (Mfn2) is a mitochondrial protein. What is its apparent role? Can you think of a reason why overexpression could be protective against a stress? Is it reasonable that overexpression of this gene could also cause problems (if so, how)? How did the authors arrange that Mfn2 was only upregulated in the brain and spinal cord of TMFN mice, and not in other tissues of the mice? How do they demonstrate this? Briefly describe the roles of these molecules in immunity/inflammation:IL-1βIL-6IL-10TNFα They all belong to a class of molecules; what is that class called? What evidence do the authors provide that…Please assist ASAP,a like is guaranteed!Pls help ASAP and show all work and explanations
- Give detailed Solution with explanation needed..don't give Handwritten answer (don't use Ai for answering this question)READ: They key to large-scale communication in the entire nervous system is the ability to pass nerve impulses on a small scale from one neuron to the next so that signals can be transmitted throughout the entire body. The junction between two neurons is called a synapse, and is the critical space that mediates the transfer of a signal from the presynaptic neuron (the sender) to the postsynaptic neuron (the receiver) or even an effector cell (like a gland or muscle cell.) You circled a synapse in Model 1. Synapses can be electrical or chemical. Electrical synapses transmit electrical signals via gap junctions. A channel protein connects the cytoplasm of two adjacent neurons so that ions can flow directly from one cell to another to pass on the signal. However, the most common type of synapse is a chemical synapse. These utilize chemical signals, called neurotransmitters, to transmit the signal across the synaptic cleft. This is a slower process, but allows for much greater precision…e Translate G what tissue type between orga x + ses/49703/quizzes/244278/take/questions/5325213 i. Name the two levels of the hierarchy of structural organization represented on the model below. ii. Name the storage form of glucose (a polymer) that is found in animal cells (i.e. our cells). iii. Consider the following experiment: a. Intracellular solute concentration = 200 mOsm b. Extracellular solute concentration = 300 mOsm In which direction will water move? Choose the letter. note: There are no dots or arrows associated with this model. i. ii. ii. Choose a or b Rgvious Next