Which of the following best describes the mechanism behind pleiotropy? A. A single gene controls a single character B. Effect of a gene on metabolic pathways resulting to varied phenotypes C. Effect of multiple genes on multiple pathways D. Effect of multiple alleles on a biochemical pathway >
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- Write a short explanatory essay on the following statement: “Incases of genetically programmed phenotypic plasticity, naturalselection acts on the norm of reaction. Thus the norm of reactionas a whole—rather than any one phenotype—determines ifselection is positive or negative.”The role of the TPMT genotype in response to treatment emphasizes the importance of pharmacogenomics. What changes in treatment would be recommended for someone homozygous recessive for TPMT, compared to someone that is homozygous dominant?Gene dosage is important for a number of genetic phenomenon. Name two and explain their relationship to the genotype and phenotype observed.
- Pleiotropy is defined by the following: O when a gene responds differently to multiple environmental conditions O when a single gene influences multiple phenotypic traits O when the action of one gene is modified by one or more genes O reversible changes in a gene that do not alter the DNA sequenceA complex biochemical pathway is shown below, along with the alleles that either promote or inhibit each step of the pathway leading to a phenotype. Gene A has alleles A and a, B has alleles B and b, and so forth. Genes B and C are duplicate dominant epistatic lethal as heterozygotes (i.e. Bb Cc are lethal). Genes D and E are duplicate dominant epistatic (i.e. dd eg = desired phenotype). If I were to cross AA Bb cc Dd Ee with aa BB Cc Dd e, (i) (ii) What proportion of all offspring don't show the phenotype? What proportion of offspring survive? Gene A Gene B B Gene D a Gene C Gene EWhich of the following statements describes the multifactorial inheritance in genetics? O Phenotype is determined by different environmental factors. O One locus is associated with variable phenotypes of a trait. Several loci are associated with the trait. One locus is associated with different traits. O Environment plays minimal or no role in the final phenotype.
- For each of the following genetic topics, indicate whether it focuses on transmission genetics, molecular genetics, or population genetics. a. Analysis of pedigrees to determine the probability of someone inheriting a traitb. Study of people on a small island to determine why a genetic form of asthma is prevalent on the islandc. Effect of nonrandom mating on the distribution of genotypes among a group of animals d. Examination of the nucleotide sequences found at the ends of chromosomese. Mechanisms that ensure a high degree of accuracy in DNA replicationf. Study of how the inheritance of traits encoded by genes on sex chromosomes (sex-linked traits) differs from the inheritance of traits encoded by genes on nonsex chromosomes (autosomal traits)Which of the following is the definition of the term named Genes? a.Refers to genes that have identical alleles b.Genetic constitution of an organism c.Alternative form of a gene d.Trait expressed in the F1 generation e.Fundamental physical and functional unit of heredity f.Physical expression of traits of an organismIndicate which of the four major classes of rearrangements (deletions, duplications, inversions, and translocations) are most likely to be associated with each of thefollowing phenomena. In each case, explain the effect.a. semisterilityb. lethalityc. vulnerability to mutationd. altered genetic mape. haploinsufficiencyf. neomorphic mutationg. hypermorphic mutationh. crossover suppressioni. aneuploidy
- Which of the following statements best describe the equation P = G + E + (G X E)?* a. The phenotype is the sum of the genotype and the environment. b. The phenotype of an organism is determined by its genetic traits. c. The phenotype is the total characteristics displayed by an organism that results from the expression of the genes as well as the influence of environmental factors. d. The phenotype is the observable and measurable characteristics of an organism as a result of the interaction of the genes of the organism, environmental factors, and random variation.Are the following events best explained by mutation or epimutation? A. imprinting of the Igf2 geneB. variation in coat color in mice carrying the Avy alleleC. formation of cancer cellsD. variation in flower color between different strains of pea plants,such as purple versus whiteE. X-chromosome inactivationDuring the course of a research project you generate a gene knockout line in Arabidopsis thaliana to study the function of a gene you believe plays a crucial role in cellular metabolism. You note that the initial transformants are a bit smaller than normal. In subsequent crosses you are unable to isolate homozygotes for the knockout allele. Heterozygotes in subsequent generation are still a bit smaller than the homozygous wild type plants. Explain what is happening.