Answered: Which method would you use to perform…

Which method would you use to perform these reactions, Grignard carboxylation or Nitrile hydrolysis? Reaction #1: Reaction #2: H3C CH₂Br CH3 CH₂COOH CH3 H3C. COOH

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter17: Carboxylic Acids

Section: Chapter Questions

Problem 17.28P: Complete the following acid-base reactions. (a) CH3CH2CH2CH2Li + CH3COOH (b) CH3CH2CH2CH2MgBr +...

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Concept explainers

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.

Question

G.43.

Which method would you use to perform these reactions, Grignard carboxylation or Nitrile hydrolysis?
Reaction #1:
Reaction #2:
H3C
CH₂Br
CH3
CH₂COOH
CH3
H3C.
COOH

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