Which amino acids would be expected to produce a similar sickling effect if substituted for Val at position 6? arginine phenylalanine lysine leucine. alanine. Sickling occur in deoxyhemoglobin S but not in oxyhemoglobin S. Oxyhemoglobin has a small, hydrophobic pocket
Neutral Amino Acids
Amino acids which do not have any charge on them are neutral amino acids.
Globular Protein
The globular proteins refer to the shape of protein specifically spherical in nature apart from spherical form fibrous, disordered and membrane-bound proteins exist. These globular proteins are miscible in water and form a colloidal solution rather than other types which might not exhibit solubility. Many classes of the fold are found in globular proteins, which render them a sphere shape. Globular fold containing proteins usually are referred to by the term globin.
Dimer
Dimers are basic organic compounds, which are derivates of oligomers. It is formed by the combination of two monomers which could potentially be strong or weak and in most cases covalent or intermolecular in nature. Identical monomers are called homodimer, the non-identical dimers are called heterodimer. The method by which dimers are formed is known as “dimerization”.
Dipeptide
A dipeptide is considered a mixture of two distinct amino acids. Since the amino acids are distinct, based on their composition, two dipeptide's isomers can be produced. Various dipeptides are biologically essential and are therefore crucial to industry.
![The mutated form of hemoglobin (hemoglobin S, or HbS) in sickle-cell anemia results from
the replacement of a glutamate residue by a valine residue at position 6 in the ß chain of the
protein. Normal hemoglobin is designated HbA.
Under conditions of low [O₂], HbS aggregates and distorts the red blood cell into a sickle
shape. See image of eight aggregated HbS molecules. Sickled red blood cells are relatively
inflexible and may clog capillary beds, causing pain and tissue damage. The sickled red
blood cells also have a shorter life span, leading to anemia.
Which amino acids would be expected to produce a similar sickling effect if substituted for Val at position 6?
arginine
phenylalanine
Aggregate of HbS molecules
lysine
leucine
alanine
Sickling occurs in deoxyhemoglobin S but not in oxyhemoglobin S. Oxyhemoglobin has a small, hydrophobic pocket in a B
chain ranion located in the interior of the neotain In daaxshamaalahin homauar thic nookat is laastad on the curfona of tha
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