What would you expect if a patient carries a mutation in Hexokinase IV (HKIV) that lowers the Km from 10mM to 4mM? O HKIV is still regulated by its product G6P so nothing will change O This change is irrelevant since HKIV is only expressed in muscle cells O mutant HKIV will have a greater change in reaction velocity in response to change in Glucose levels O mutant HKIV will have a reduced change in reaction velocity in response to change in Glucose levels O Mutant HKIV will always be less saturated by glucose compared to WT HKIV

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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What would you expect if a patient carries a mutation in Hexokinase IV (HKIV) that lowers the Km from 10mM to 4mM?
O HKIV is still regulated by its product G6P so nothing will change
This change is irrelevant since HKIV is only expressed in muscle cells
mutant HKIV will have a greater change in reaction velocity in response to change in Glucose levels
O mutant HKIV will have a reduced change in reaction velocity in response to change in Glucose levels
O Mutant HKIV will always be less saturated by glucose compared to WT HKIV
Transcribed Image Text:What would you expect if a patient carries a mutation in Hexokinase IV (HKIV) that lowers the Km from 10mM to 4mM? O HKIV is still regulated by its product G6P so nothing will change This change is irrelevant since HKIV is only expressed in muscle cells mutant HKIV will have a greater change in reaction velocity in response to change in Glucose levels O mutant HKIV will have a reduced change in reaction velocity in response to change in Glucose levels O Mutant HKIV will always be less saturated by glucose compared to WT HKIV
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