What is the primary advantage to using a chimeric mouse in animal trials of a new drug and what are two ways that this approach might lead to inaccurate data?
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What is the primary advantage to using a chimeric mouse in animal trials of a new drug and what are two ways that this approach might lead to inaccurate data?
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- What is metrology? How does metrology relate to Analytical Biotechnology? Relate the terms error and uncertainty to the concepts of precision and accuracy. What are the major parameters of instrumental response?what are the short comings of randomized clinical trials ?What are the 3 R's in animal experiments? Explain each.
- Discuss the different designs for collecting the information desired in a Randomised Controlled Trial (RCT).What is the purpose of randomization in a randomized controlled trial? a. To ensure that there are fewer adverse effects b. To ensure that participants are unaware as to whether they are receiving the medicine or the placebo c. To ensure that participants in the treatment group and those in the pacebo (or control) group are as similar as possible when the study begins d. To ensure that participants in the trial are representative of the target populationHow can performance bias be reduced in animal experiments in conducting vivo experiments
- Based on the NCBI blast below Are there any pathogenic missense mutations in the human gene FGFR3? Also do they have any identical amino acids to prove a mouse is the best model to test the fgfr3 gene?Since the query’s are matching does that mean the house mouse( mus musculus) is a good model to test in the human FGFR3 gene(achondroplasia). The NCBI blastp and reciprocal analysis are belowWhat are advantages and disadvantages of these two methods?
- Why can imputation lead to bias in GWAS studies?What is Long QT Syndrome? What are three genes associated with Long QT Syndrome?Nicotinamide Adenine Dinucleotide (NAD) Assay (SIGMA Kit MAK037) analysis of tissue samples initially requires: centrifugation at 13,000g for 10min to homogenise tissue. centrifugation of 20mg of tissue at 2,000rpm with Extraction Buffer. freezing and thawing for 2 cycles of 20min before addition of Extraction Buffer. homogenization of PBS washed tissue with Extraction Buffer.