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(vi) The final step in your reaction sequence is alkylation with benzylbromide. Draw the structure of the final cyclic chiral product C. Indicate the chiral centre and give any important reaction conditions. .N. LOME LDA PHCH,Br A C + LİBr

(vi) The final step in your reaction sequence is alkylation with benzylbromide. Draw the structure of the final cyclic chiral product C. Indicate the chiral centre and give any important reaction conditions. .N. LOME LDA PHCH,Br A C + LİBr

Organic Chemistry
Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter20: Carboxylic Acids And Nitriles
Section20.SE: Something Extra
Problem 25MP: Acid-catalyzed hydrolysis of a nitrile to give a carboxylic acid occurs by initial protonation of...
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(vi) The final step in your reaction sequence is alkylation with benzylbromide. Draw the structure of the final cyclic chiral product C. Indicate the chiral centre and give any important reaction conditions. .N. COMM LDA PHCH,Br А + LİB. The structure of C is;
Transcribed Image Text:(vi) The final step in your reaction sequence is alkylation with benzylbromide. Draw the structure of the final cyclic chiral product C. Indicate the chiral centre and give any important reaction conditions. .N. COMM LDA PHCH,Br А + LİB. The structure of C is;
Question 1 Alkylation of valerolactim ethers (1) is an attractive route to a-alkyl-ô-amino acids; important building blocks for medicinally important compounds. After discussion with your supervisor you decide to test two compounds, lithium diisopropylamide (LDA) and n-propyllithium (n-PrLi), as possible metalating reagents. The strategy is To synthesise fresh solutions of LDA and n-PrLi. To test them in reactions with the valerolactim ether (1) To obtain the possible cyclic chiral product on alkylation with benzylbromide LOME valerolactim ether (1)
Transcribed Image Text:Question 1 Alkylation of valerolactim ethers (1) is an attractive route to a-alkyl-ô-amino acids; important building blocks for medicinally important compounds. After discussion with your supervisor you decide to test two compounds, lithium diisopropylamide (LDA) and n-propyllithium (n-PrLi), as possible metalating reagents. The strategy is To synthesise fresh solutions of LDA and n-PrLi. To test them in reactions with the valerolactim ether (1) To obtain the possible cyclic chiral product on alkylation with benzylbromide LOME valerolactim ether (1)
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