Two different capsule formulations of cilostazol, which is poorly water soluble, were prepared. In a group of volunteers, the relative bioavailabilies of the two formulations were calculated relative to an oral suspension of the drug given to the same group at the same dose. = 0.9 Formula A (mechanically ground drug powder) F rel= Formula B (stabilised amorphous powder) Frel=2.1 Frel FAXFGXFH After consideration of the equation shown above, what is the likely reason for the increased F rel of formula B compared to formula A? O a. FA is increased. b. FG is increased. Oc. FH is increased. d. None of these are likely.
Two different capsule formulations of cilostazol, which is poorly water soluble, were prepared. In a group of volunteers, the relative bioavailabilies of the two formulations were calculated relative to an oral suspension of the drug given to the same group at the same dose. = 0.9 Formula A (mechanically ground drug powder) F rel= Formula B (stabilised amorphous powder) Frel=2.1 Frel FAXFGXFH After consideration of the equation shown above, what is the likely reason for the increased F rel of formula B compared to formula A? O a. FA is increased. b. FG is increased. Oc. FH is increased. d. None of these are likely.
Chemistry: Principles and Reactions
8th Edition
ISBN:9781305079373
Author:William L. Masterton, Cecile N. Hurley
Publisher:William L. Masterton, Cecile N. Hurley
Chapter10: Solutions
Section: Chapter Questions
Problem 86QAP: A martini, weighing about 5.0 oz (142 g), contains 30.0% by mass of alcohol. About 15% of the...
Related questions
Question
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Recommended textbooks for you
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry: An Atoms First Approach
Chemistry
ISBN:
9781305079243
Author:
Steven S. Zumdahl, Susan A. Zumdahl
Publisher:
Cengage Learning